Navigation Links
Drug to Prevent Preterm Labor Shows Little Benefit

No difference found between intensive nifedipine therapy and placebo, researchers say

WEDNESDAY, Nov. 26 (HealthDay News) -- A muscle relaxant drug widely used to prevent premature birth when women go into early labor is no more effective than a placebo at maintaining pregnancy, after the initial spell of preterm labor is stopped.

So say U.S. researchers who conducted the first ever placebo-controlled test of nifedipine and its effect on premature delivery with prolonged treatment. The study included 71 women who'd been successfully treated for preterm labor between 24 and 34 weeks of pregnancy. The women were randomly assigned to receive either nifedipine or placebo every six hours until 37 weeks of pregnancy or delivery, whichever came first.

The team found no differences between the two groups of women in terms of whether their pregnancies lasted until 37 weeks; of how long delivery was delayed; or in their babies' gestational age, birth weight and complications of prematurity. About 40 percent of women in both groups reached 37 weeks of pregnancy, with delivery delayed an average of one month.

The study is published in the December issue of the journal Obstetrics & Gynecology.

"Medication use should be minimized in pregnancy unless it's clearly indicated," lead author Dr. Deirdre Lyell, an assistant professor of obstetrics and gynecology at Stanford University School of Medicine, noted in a school news release.

Serious side effects are rare in pregnant women treated with nifedipine, she said, but even a low risk isn't worthwhile if a drug provides no benefit.

"We all want to prevent preterm birth, but prolonged treatment with nifedipine doesn't appear to be the answer," said Lyell, who believes a larger study of nifedipine is warranted.

More information

The U.S. National Institute of Child Health and Human Development has more about preterm labor and birth.

-- Robert Preidt

SOURCE: Stanford University, news release, Nov. 25, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford/Packard study shows no benefit from drug widely used to prevent premature births
2. Drug Abuse and Violence Prevention Program Generates $16 Million in Potential Savings
3. US$18.5 million grant makes male circumcision a top-tier HIV prevention strategy
4. The 5-Percent Plan: Preventing Diabetes and Heart Disease
5. Heartworm Disease Prevention Protects Pets, Wallets
6. Robert Wood Johnson Foundation Announces Grant Recipients for $18 Million Dollar Initiative to Prevent Intimate Partner Violence
7. Ginkgo Biloba for Prevention of Dementia
8. Stay Upbeat, Exercise to Help Prevent Cancer in Old Age
9. Indoor Allergy Week - Cleanaer™, the New Air Purifier that Helps Prevent Spread of the Common Cold While Removing Airborne Allergen
10. Vitamin C, E Supplements Wont Help Prevent Cancer
11. Early Life Peanut Consumption Might Prevent Allergy
Post Your Comments:
Related Image:
Drug to Prevent Preterm Labor Shows Little Benefit
(Date:11/24/2015)... ... November 24, 2015 , ... American Specialty ... Program have announced their endorsement of the Medical Fitness Network (MFN), a ... proud to have the MFN as one of our endorsed organizations,” said ASH ...
(Date:11/24/2015)... N.Y. (PRWEB) , ... November 24, 2015 , ... Autism ... Tuesday, the global movement driven by social media and the generosity of people around ... then encourage their social media networks to give – and share the personal stories ...
(Date:11/24/2015)... ... November 24, 2015 , ... World Patent ... Blending, a household invention that revolutionizes the vending machine industry by providing healthy ... is worth $2 billion," says Scott Cooper, CEO and Creative Director of World ...
(Date:11/24/2015)... , ... November 24, 2015 , ... Robert Yeager ... Trend Report . Throughout the past year there have been multiple breakthroughs and challenges ... During this transition, PharmMD has enabled their customers and partners to stay ahead of ...
(Date:11/24/2015)... ... November 24, 2015 , ... Dehydration, defined as a loss of body water ... the hot sun, and heat stroke and death will quickly follow. A normal human ... Kleyne. Every cell, system and structure requires water to function properly. Kleyne, who believes ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015   HeartWare International, Inc . ... miniaturized circulatory support technologies that are revolutionizing the treatment ... Chief Executive Officer Doug Godshall is scheduled ... Annual Healthcare Conference on December 1, 2015 at 3:00 ... in New York . ...
(Date:11/24/2015)... BERN, Switzerland , November 24, 2015 /PRNewswire/ ... Biomedical Engineering Research of the University of ... Diabetes and Clinical Nutrition of the Bern University Hospital ... exclusive collaboration to develop a novel generation artificial pancreas. ... delivery of insulin for diabetic patients with the unequalled ...
(Date:11/24/2015)... 2015 F1000Workspace - a research ... it was launched just six months ago. --> ... platform for scientists - since it was launched just six ... loaded on to F1000Workspace - a research collaboration, ... was launched just six months ago. --> ...
Breaking Medicine Technology: