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Drug therapy to bolster immune system cells found effective toward childhood cancer
Date:5/15/2008

CINCINNATI, OH - Researchers from The University of Texas M. D. Anderson Cancer Center have found a possible approach to therapy that may make cancer cells more sensitive to attack by immune system cells while making the immune system cells more powerful.

The combination has the potential to treat different types of childhood cancer, including osteosarcoma, leukemia and neuroblastoma, while possibly sparing young patients from more difficult therapies such as stem cell transplant or more toxic chemotherapy.

Dean Lee, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has found that combining the epigenetic drug MS-275 with natural killer (NK) cells makes osteosarcoma cells more sensitive to NK cells while making the NK cells more lethal to the tumor, as presented at the American Society of Pediatric Hematology/Oncology annual meeting on May 15.

"Traditional chemotherapy drugs kill any fast-growing cells like cancer, but they also killed healthy fast-growing cells like hair, bone marrow and mucous membranes, making the drugs very toxic," says Lee, senior investigator on the study. "There's a new class of drugs that takes cells that aren't properly regulated and makes them behave. In our study, we found that these drugs make tumor cells more recognizable and vulnerable to natural killer cells."

Osteosarcoma is a rare pediatric cancer, but the most common bone cancer found in children. According to the American Cancer Society, it affects approximately 400 children, adolescents and young adults under the age of 20 in the United States each year, and nearly a third of those relapse. Relapsed and metastatic osteosarcomas are rarely sensitive to treatment with chemotherapy or radiation, but several studies have suggested these tumors may be immunologically responsive.

Lee's study of human tissue cultures shows the synergistic effect of combining NK cells with histone
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Contact: Sara Farris
sfarris@mdanderson.org
281-467-1337
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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