Navigation Links
Drug that restricts blood supply to prostate tumors delays disease progression
Date:6/8/2010

A blood vessel-blocking drug called tasquinimod slowed the rate of disease progression in a clinical trial of 200 prostate cancer patients, according to experts at Johns Hopkins, Roswell Park Cancer Institute and Duke University.

Tasquinimod is a so-called "anti-angiogenesis" drug that squeezes off blood supply to prostate tumors by blocking new blood vessel development. Tumors require these vast networks of blood vessels to supply nutrients.

The multicenter trial at seven institutions, including Johns Hopkins, enrolled prostate cancer patients whose disease had spread to take a once-daily pill for four weeks. At six months, 57 percent of men taking tasquinimod had no disease progression as compared with 33 percent taking a placebo. Overall, the drug added approximately 12 weeks of time that the disease did not worsen (progression-free survival).

The most common side effects included gastrointestinal problems, fatigue and bone pain, and some rare occurrences of heart attack, stroke and deep vein thrombosis.

"Given these results, we feel it is reasonable to move forward with Phase III studies," says Michael Carducci, M.D., professor at the Johns Hopkins Kimmel Cancer Center, who will lead the next phase of an international study of the drug. "After exploring the drug as a single agent, we may study it in combination approaches with other prostate cancer drugs."

Research leading to tasquinimod began in the early 1990s when John Isaacs, Ph.D., professor at the Johns Hopkins Kimmel Cancer Center, found that a drug called linomide, which had been tested in multiple sclerosis, restricted blood supply to prostate tumors. However, the drug's cardiac side effects were too toxic for humans, so Isaacs in collaboration with the pharmaceutical company Active Biotech identified tasquinimod for clinical testing after searching for drugs similar to linomide with the same blood vessel action but with less toxicity.

Is
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Psychologists Say New Jerseys Largest Health Plan Violates Patient Privacy, Restricts Access to Care and Wastes Taxpayer Money
2. ASCO data show serum DNA blood tests detect cancers with high sensitivity and specificity
3. Glucose Tattoo Could Track Blood Sugar Levels for Diabetics
4. DUI Phoenix Attorney Earns Not Guilty Verdict and Hung Jury in .104 Blood Alcohol Content DUI Case
5. First paper dipstick test for determining blood type
6. Nottingham research leads to blood test for early detection of cancer
7. Blood flows differently through the brains of schizophrenic patients
8. Report Finds Control of High Blood Pressure Improving
9. Frequent Doctor Visits Help Diabetics Control Blood Pressure
10. Fewer Sugary Drinks, Less High Blood Pressure
11. A new cancer vaccine starves tumors of blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... San Jose, California (PRWEB) September 19, 2014 ... agents, an integral part of the medical imaging market, ... organs. Effervescent technology developments over the past three decades ... medical diagnostics. From barium and iodine based agents used ... as gold nanoparticles and radiopharmaceuticals, imaging agents have witnessed ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 ... ligand assays used for detection and quantification of ... given sample. Driven by steady expansion in immunodiagnostics ... the global immunoassay systems market has evolved remarkably ... conditions, such as diabetes, cardio-vascular ailments, infectious diseases, ...
(Date:9/19/2014)... September 19, 2014 The ... traditional Scandinavian style of eating, is making ... like Diet Doc’s medical weight loss ... and eating good food which leads to ... on teaching patients to understand how diet ...
(Date:9/19/2014)... 19, 2014 The Relaxation Drink ... to 2014. Industry operators were able to mass produce ... as well as establish distribution contracts with nation-wide retailers. ... part to its novelty; energy drinks have only been ... industry operators have been able to establish brands and ...
(Date:9/19/2014)... 2014 Recent financial data reveled ... increased their sales by 7% in the last quarter ... industry can be used as a bellwether to determine ... This data has been proven to show trends with ... transportation. Other non-trucking data is largely influenced by international ...
Breaking Medicine News(10 mins):Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 2Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 3Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 4Health News:Growing Preference for Non-Invasive Diagnostics Spurs Growth in the Global Immunoassay Systems Market, According to New Report by Global Industry Analysts, Inc. 2Health News:Growing Preference for Non-Invasive Diagnostics Spurs Growth in the Global Immunoassay Systems Market, According to New Report by Global Industry Analysts, Inc. 3Health News:Growing Preference for Non-Invasive Diagnostics Spurs Growth in the Global Immunoassay Systems Market, According to New Report by Global Industry Analysts, Inc. 4Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 2Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 3Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 4Health News:Relaxation Drink Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Relaxation Drink Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:LeaseQ Announces Good News For The Truck Leasing Industry As Truck Rentals In The U.S Continues to Gain Traction 2Health News:LeaseQ Announces Good News For The Truck Leasing Industry As Truck Rentals In The U.S Continues to Gain Traction 3
... study conducted by the researchers at New York University School ... Asian immigrants are carriers// of the hepatitis B virus. These ... But it is surprising to know that most of the ... people who are infected had no health insurance. The rate ...
... place on record the exemplary work of art by students from ... by Oman in the ‘Unite for children Unite against Aids’ campaign ... for Children Unite Against Aids’ campaign encompasses four major goals spread ... percentage of the young victims of HIV/Aids; to provide better services ...
... Health workers by the Ontario government, to beat a possible ... from critics // , who see this is politically motivated ... The opinion doing the rounds is that the kits ... ,According to health minister George Smitherman, 15,000 emergency kits will ...
... Exercising for at least for half an hour a day and ... serving of vegetables and fish, may be the key// to longevity ... Health Organization. ,According to the study, exercising just 30 ... cycling and even climbing the stairs are included in the tally, ...
... University have developed ,the first knee replacement shaped to ... the U.S. Food and Drug Administration, and will be ... ,Dr. Aaron G. Rosenberg and Dr. Richard A. Berger, ... who sought to address shape-related differences of a woman’s ...
... A systematic review of studies has revealed that surgery ... intrauterine medication for women experiencing heavy periods in reducing ... ,However, on subjective measures of effectiveness — satisfaction and ... (IUD) is as effective as surgery, the review found. ...
Cached Medicine News:Health News:East Asian Immigrants Bring Hepatitis to New York 2Health News:Shapelier Knee Replacements for Women 2Health News:Shapelier Knee Replacements for Women 3Health News:Shapelier Knee Replacements for Women 4Health News:Surgery or IUD for Heavy Periods 2Health News:Surgery or IUD for Heavy Periods 3
(Date:9/19/2014)... 2014 Five MinuteClinic walk-in medical clinics are opening inside ... area. Three clinics opened in Memphis and ... will be added in Springfield on September ... is expected to open October 22.  MinuteClinic is the largest and ... United States . The Memphis ...
(Date:9/19/2014)... Sept. 19, 2014 Larry J. Merlo , ... ), will speak before the National Press Club in ... company,s recent move to stop selling tobacco products and its ... of health. "Dramatic changes in our health care ... and government," Merlo has said. "CVS Health has a truly ...
(Date:9/19/2014)... , September 19, 2014 ... Equipment Type (Benchtop, Mobile, Industrial, & Laboratory), Industry ... (Tray-style, Manifold, & Rotary) & Geography - Global ... defines and segments the lyophilization market on the ... analyses and projections of the market size of ...
Breaking Medicine Technology:MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3
... Streamline Health Solutions, Inc. (Nasdaq: STRM ... for hospitals, announced today that two of its clients, ... North Carolina, contracted with Streamline Health to implement new ... began the beta phase of integration earlier this year, ...
... July 28, 2011 Pacira Pharmaceuticals, Inc. (Nasdaq: ... financial results for the company,s second quarter ended June 30, ... Aug. 11, 2011. The Pacira management team will host a ... and upcoming developments on Thursday, Aug. 11, 2011 at 9 ...
Cached Medicine Technology:Streamline Health Announces Two Clients Have Contracted for Multiple Integrations to Their Epic Systems 2Streamline Health Announces Two Clients Have Contracted for Multiple Integrations to Their Epic Systems 3Streamline Health Announces Two Clients Have Contracted for Multiple Integrations to Their Epic Systems 4Pacira Pharmaceuticals, Inc. Announces Timing for Second Quarter 2011 Financial Results Webcast and Conference Call 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: