Navigation Links
Drug shows promise in prostate cancer spread to bone
Date:6/7/2011

ANN ARBOR, Mich. A new drug to treat prostate cancer shows early promise, particularly against tumors that have spread to the bone, a multi-site study shows.

The drug Cabozantinib is designed to target mainly two important pathways linked to the growth and spread of prostate cancer. The drug had the most effect on tumors that had spread to the bone.

"Not only did three-quarters of bone scans have partial or complete resolution, but this was accompanied by improvement in bone pain and decreased need for narcotic use," says lead study author Maha Hussain, M.D., FACP, professor of internal medicine and urology and associate director of clinical research at the University Michigan Comprehensive Cancer Center.

Hussain presented the findings at the American Society of Clinical Oncology annual meeting.

The trial enrolled 171 men with metastatic prostate cancer. In more than three-quarters of the men enrolled, cancer had spread to the bone.

Researchers found 76 percent of patients saw some or all of their tumor shrink on bone scans following treatment with Cabozantinib. In addition, among patients who were on narcotics due to bone pain, 67 percent reported less pain and 56 percent either stopped taking narcotics or reduced the dosage. In addition, more than two-thirds of patients had some tumor regressions in areas of spread outside the bone. The treatment effects lasted on average 29 weeks.

The study found moderate side effects from Cabozantinib, including fatigue, gastrointestinal symptoms and high blood pressure.

"What's interesting about this drug is it brings to the table something we haven't seen before. Dramatic improvements in bone scans are unprecedented in this disease. Despite measurable progress, current treatment options for advanced prostate cancer tend to be modest in effect, so adding to and improving these options is a high priority," Hussain says.

Hussain cautions that this is very early data, but it opens a new door for further investigation. The manufacturer, Exelixis, has developed a randomized clinical trial that is currently open at the U-M Comprehensive Cancer Center and other locations. For information, call the U-M Cancer AnswerLine at 800-865-1125.

U-M researchers are also planning a clinical trial with this drug in patients with metastatic prostate cancer who have had no previous chemotherapy. Laboratory research at the University of Michigan will look to better understand Cabozantinib's effects on the bone. Cabozantinib is not approved by the U.S. Food and Drug Administration.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. PARTNER shows similar 1-year survival for catheter-based AVR and open AVR in high-risk patients
2. Combination antibody therapy shows promise in metastatic melanoma
3. ASCO: Experimental vaccine made from frozen immune cells shows promise for prostate cancer patients
4. Combination therapy shows promise for rare, deadly cancer caused by asbestos
5. Melanoma Vaccine Shows Promise in Trial
6. Violence Doesnt Make TV Shows More Enjoyable for Kids
7. U.S. Southeast Stroke Belt Also Shows Higher Rates of Cognitive Decline
8. Common transplant drug inhibits breast cancer growth, UNC laboratory study shows
9. CDC Report Shows Bacterial Meningitis Cases on the Decline
10. Study shows 19 percent of young adults have high blood pressure
11. Study shows elderly drivers support competency tests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug shows promise in prostate cancer spread to bone 
(Date:12/7/2016)... ... , ... “Tomorrow Trump Goes To Washington”: a brief but engaging illustration ... to America. “Tomorrow Trump Goes To Washington” is the creation of published author, Nancy ... country. , Nancy attributes her patriotic nature to her WWII veteran father. She ...
(Date:12/7/2016)... ... (PRWEB) December 07, 2016 , ... Angioma Alliance ... cerebral cavernous angiomas, was awarded a grant from the Julian Grace Foundation to ... Mexico has more people with cavernous angioma than anywhere in the world. Most ...
(Date:12/7/2016)... ... , ... NuevaCare, a leading home care agency based in San Mateo but ... as part of its ambitious website relaunch. As Bay Area clients scramble to find ... serving their city. The new site has several key city-specific pages to address this ...
(Date:12/6/2016)... ... 06, 2016 , ... The International Vaccine Institute (IVI) and ... the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The collaboration will accelerate MERS-CoV vaccine ... deployment in the event of a future outbreak. , IVI and GeneOne held ...
(Date:12/6/2016)... ... December 06, 2016 , ... According to a November ... such as consuming too many mints or not drinking enough water, which can cause ... California Dental Care notes that good oral hygiene not only helps reduce the possibility ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... , Dec. 6, 2016 Eurofins ... accreditation from the College of American Pathologists (CAP) ... (CLIA) for its new laboratory in ... moved its North American headquarters. "Our ... sequencing -- which is still considered the ,Gold ...
(Date:12/6/2016)... -- With opioids commonly used for pain management for workplace injuries, ... has led to nationwide fatalities. The synthetic opioid called ... heroin or morphine, resulting in likelihood of addiction, abuse or death. ... , , ... Behavioral Health for HMC HealthWorks, explained the opioid drug is less ...
(Date:12/6/2016)... new study released today by the Alliance for ... Drug Pricing Program will continue to expand at an unprecedented ... exceed $23 billion in total purchases at the 340B price. ... Part B drug reimbursement purchases over the next five years. ... of data on total drug purchases through 340B from 2005 ...
Breaking Medicine Technology: