Navigation Links
Drug shows promise for effectively treating metabolic syndrome
Date:7/3/2014

(SALT LAKE CITY)University of Utah researchers have discovered that an enzyme involved in intracellular signaling plays a crucial role in developing metabolic syndrome, a finding that has a U of U spinoff company developing a drug to potentially treat the condition.

The researchers, led by Jared Rutter, Ph.D., professor of biochemistry, hope to begin human clinical trials of a drug in the next couple of years.

"The approved drug therapies do not treat or prevent this condition in most people," says Rutter, senior author of a study describing the research published July 3, 2014, in Cell Reports. "But given the results of our research with mouse and rat models, we are hopeful that metabolic syndrome can be effectively treated with drug therapy someday soon."

Metabolic syndrome, a group of conditions that increases the risk for developing heart disease, diabetes and stroke, is estimated to affect up to 25 percent of adults. Public health officials believe metabolic syndrome has reached epidemic proportions in the United States and elsewhere.

Metabolic syndrome includes disorders such as high blood pressure, high blood sugar levels, abnormal cholesterol readings, and obesity. One of the prominent features of the syndrome is the excessive production and storage of fatty acids and triglycerides.

In research with rodents, Rutter, doctoral student and first author on the Cell Reports study Xiaoying Wu, and Allen Nickols of BioEnergenix, a company Rutter co-founded in 2009, discovered that an enzyme known as PASK stimulates the overproduction of fatty acids and triglycerides. PASK works by chemically modifying other proteins in order to alter their specific functions. One of the proteins it modifies is SREBP-1c, which functions as the master regulator of all of the enzymes that make fat.

Using a drug candidate being developed by the University of Utah spinoff company BioEnergenix, the researchers prevented
'/>"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fear, not data, motivates sunscreen users, research shows
2. New research study shows huge savings for health care
3. Penn study shows changing roles of physicians with MBAs
4. New research shows link unlikely between insomnia symptoms and high blood pressure
5. Study shows cost-effectiveness of smoking cessation counseling during hospitalization
6. Gut bacteria predict survival after stem cell transplant, study shows
7. New post-hoc analysis shows patients with type 2 diabetes undergoing intensification of insulin therapy experienced less nighttime hypoglycemia while being treated with Januvia (Sitagliptin) compared to placebo
8. Moffitt study shows utilizing genetic health care professional reduces unnecessary testing
9. Miriam Hospital study shows how to make statewide health campaigns more effective
10. MRI shows brain abnormalities in late preterm infants
11. Presurgical SPECT/CT shows more cancer than current standard
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... FL (PRWEB) , ... July 29, 2015 , ... According ... fruit flies revealed a gene which is directly responsible for stimulating and perpetuating alcohol ... published in the journal entitled Proceedings of the National academy of Sciences, and has ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... anticipating testing regulations imposed by the FDA for nicotine laced liquid products. Their ... electronic cigarettes have raised considerably. E-Cigarettes are particularly troublesome to addiction professionals as ...
(Date:7/29/2015)... ... July 29, 2015 , ... CrossFit 269, offering a nationally ... Kalamazoo Strength & Conditioning. , The name change coincides with the release of ... training center over the past three years,” according to Jack Kelly, the center’s ...
(Date:7/29/2015)... ... July 29, 2015 , ... San Fernando Valley skin doctor , Dr. ... time only, patients can get the complete treatment process with a 10 percent discount ... non-invasive treatment and have loose or sagging skin. , As the only non-surgical ...
(Date:7/29/2015)... ... July 29, 2015 , ... For the second year in a row, ... list of the 50 fastest growing companies in Jacksonville. This annual list is compiled ... July 16th, a team of Vast Bridges staffers were on hand to receive the ...
Breaking Medicine News(10 mins):Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 3Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 2Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 3Health News:Kalamazoo’s CrossFit 269 Changes Name, Opens New Website 2Health News:Kalamazoo’s CrossFit 269 Changes Name, Opens New Website 3Health News:Kalamazoo’s CrossFit 269 Changes Name, Opens New Website 4Health News:San Fernando Valley Dermatology Office, Castle Dermatology Institute, is Now Offering a Promotional Price on Ultherapy 2Health News:Vast Bridges Continues Its Swift Growth 2
... care to properly heal , ... ... On the one-year anniversary of the massive earthquake that devastated ... education and humanitarian assistance organization, is officially launching the China ...
... Health Organization urge vigilance against the "swine flu" (Type A influenza ... Huff, recommends practical tips for protecting your young child and baby ... ... Asheville, NC (PRWEB) May 12, 2009 -- The World Health Organization ...
... Chairman of the,Avon Foundation for Women, today joined ... Women leaders for a day of events to ... Breast Center at the San,Francisco General Hospital and ... making progress possible in breast cancer research and,care. ...
... Tenn., May 11 Brookdale Senior Living Inc. (NYSE: ... Executive Officer, and Mark Ohlendorf, Co-President and Chief Financial Officer, ... of America and Merrill Lynch 2009 Health Care Conference in ... 10:00 a.m. Eastern Time.The presentation is being audio webcast live ...
... Entity for Topical Acne Treatment in a DecadeCARLSBAD, Calif., May ... entered into a co-promotion agreement with Allergan for ACZONE(R) ... Representing the first new molecule in a decade approved by ... 12 years of age and older, ACZONE(R) Gel 5% combines ...
... following statement is from Regence BlueCross BlueShield President and CEO ... by a group of private-sector health industry leaders to decrease ... as much as $2 trillion over the next ten years:"I ... costs in our nation. We are a country that ...
Cached Medicine News:Health News:Project HOPE Launches Rehabilitation Program to Address Needs of Thousands Recovering from Injuries Sustained During the May 12, 2008 Earthquake 2Health News:Project HOPE Launches Rehabilitation Program to Address Needs of Thousands Recovering from Injuries Sustained During the May 12, 2008 Earthquake 3Health News:Protect Your Young Child And Baby From "Swine Flu" In Four Easy Steps 2Health News:Protect Your Young Child And Baby From "Swine Flu" In Four Easy Steps 3Health News:MultiVu Video Feed: REESE WITHERSPOON JOINS AVON FOUNDATION FOR WOMEN AND SAN FRANCISCO GENERAL HOSPITAL TO CELEBRATE 5TH ANNIVERSARY OF AVON COMPREHENSIVE BREAST CENTER 2Health News:SkinMedica to Co-Promote ACZONE(R) (dapsone) Gel 5% to Pediatricians in the U.S. 2Health News:SkinMedica to Co-Promote ACZONE(R) (dapsone) Gel 5% to Pediatricians in the U.S. 3Health News:SkinMedica to Co-Promote ACZONE(R) (dapsone) Gel 5% to Pediatricians in the U.S. 4Health News:Regence Optimistic About Health Industry Leaders' Pledge to Cut Health Care Costs 2
(Date:7/29/2015)... , July 27, 2015 ... addition of the "Pharmaceutical Packaging Market by Packaging ... Region(North America, Europe, Asia-Pacific, RoW) - Forecasts to 2020" ... pharmaceutical packaging market demand, by value is estimated to ... pharmaceutical packaging market is anticipated to show a steady ...
(Date:7/29/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hmjqff/global_wound_care ) ... Wound Care Markets (Twelve Country Analysis: Germany, France, ... India, Brazil, Australia, South Korea)" report to ... a competitive market summary. The wound care market ... and product maturity. Several of the products within ...
(Date:7/29/2015)... India , July 29, 2015 TAKE Solutions ... foray into the big data market for the Life Sciences ... US-based subsidiary, with an initial investment of 3 million ... healthcare and life sciences market (according to projections by McKinsey) ... and advanced analytics. ...
Breaking Medicine Technology:Pharmaceutical Packaging Market by Packaging Type, Raw Material & Drug Delivery Type - Forecasts to 2020 for the $80 Billion Industry 2Pharmaceutical Packaging Market by Packaging Type, Raw Material & Drug Delivery Type - Forecasts to 2020 for the $80 Billion Industry 3Global Wound Care Markets 2015 2TAKE Solutions Creates a New Subsidiary for Life Sciences Big Data in the US 2TAKE Solutions Creates a New Subsidiary for Life Sciences Big Data in the US 3
... 2012  Faruqi & Faruqi, LLP, a leading national ... at BioSante Pharmaceuticals, Inc. ("BioSante" or the "Company") ... ) The investigation focuses on ... securities laws by failing to disclose that:  (1) ...
... 9, 2012   Smith & Nephew (NYSE: ... business, is introducing the clinically proven POLARCUP™ Dual Mobility ... this year,s American Academy of Orthopaedic Surgeons (AAOS) annual ... to address the challenges of treating patients – in ...
Cached Medicine Technology:Faruqi & Faruqi, LLP Announces Investigation of BioSante Pharmaceuticals, Inc. 2POLARCUP™ Dual Mobility Hip System From Smith & Nephew Now Available in US 2POLARCUP™ Dual Mobility Hip System From Smith & Nephew Now Available in US 3
... highly pure, functional human C1q coated in the ... the first stage, CIC in the diluted patient ... are dispensed into the C1q coated assay wells. ... washing step and a ready to use conjugate ...
The K-ASSAY Rheumatoid Factor Control Set is intended to be used as a consistent test sample of known concentration for monitoring the performance of K-ASSAY immunoturbidimetric assay for quantifying...
Microalbumin Linearity Control...
The K-ASSAY ITA Lyophilized Multi-Control Set is intended to be used as a consistent test sample of known concentration for monitoring the performance of K-ASSAY immunoturbidimetric assays for the li...
Medicine Products: