Navigation Links
Drug shows positive responses, low side-effects in multiple myeloma
Date:12/7/2009

NEW ORLEANS ― The second-generation proteasome inhibitor carfilzomib is showing noteworthy response rates and low levels of adverse side effects among multiple myeloma patients in a phase II clinical trial, researchers reported today at the 51st Annual Meeting of the American Society of Hematology.

The updated data from the 17-site study focuses on patients with relapsed or resistant multiple myeloma who have received one to three prior therapies, but not the drug bortezomib, the original proteasome inhibitor.

"These findings are truly an advance for patients with multiple myeloma," said Michael Wang, M.D., associate professor, Department of Lymphoma/Myeloma at M. D. Anderson and lead author on the study. "This is an incurable, challenging disease with devastating consequences.

"While new agents are extending life expectancies, they often have adverse side effects, including severe neuropathy. Carfilzomib is showing good response rates, with an improved side effects profile," Wang said. Neuropathy is peripheral nerve pain or numbness that can become debilitating enough to halt treatment.

According to the American Cancer Society, more than 20,000 cases of multiple myeloma will be diagnosed this year in this country. More than 10,000 people will die of this disease, which is a type of blood cancer.

Better tolerated than other agents

In preclinical studies carfilzomib has been better tolerated than bortezomib, allowing consecutive day dosing and treatment over extended periods of time. Both drugs work by targeting the cell's proteasome, which destroys mutated or damaged proteins. Blocking this process causes cell death. Carfilzomib targets and binds to the proteasome differently than bortezomib.

Researchers previously observed higher response rates to carfilzomib among patients who had never been treated with bortezomib compared to those with relapsed disease following bortezomib therapy.

Fifty-seven bortezomib-naive patients have been enrolled, and 56 have received at least one dose of carfilzomib. Prior therapies included alkylators, stem cell transplant, thalidomide, lenalidimide and anthracyclines. Patients entered the trial with a variety of side effects from previous treatments including 21 patients with neuropathy (37 percent) and 12 (21 percent) with impaired renal function. The mean time from diagnosis was four years.

Response rate almost half

Carfilzomib was given intravenously on six days every 28 days for up to 12 cycles. To date, the mean number of doses administered per patient is 30. Five patients have completed the full 12-cycle protocol, and another five have completed at least nine cycles. Seventeen are continuing on in the study.

Among 51 evaluable patients, overall response rate has been 45 percent, including one complete response and 18 partial responses. An additional nine patients had minor response, and disease stabilized at least six weeks in 10 patients. This is considered noteworthy for a single-agent drug regimen in patients with tumor progression despite previous therapy with novel combinations.

"Adverse events, most of which were minor, included fatigue, nausea and anemia," Wang said. The incidence of neuropathy dropped to seven cases (12 percent) in 51 evaluable patients. Dose modifications rarely were required. No patients who entered the trial with impaired renal function needed to have their dose reduced due to renal side effects.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Concord Coalition Report Shows Eagerness for Reform, Readiness to Make Tough Choices on Fiscal Priorities
2. Bortezomib shows promise in reducing GVHD and reconstituting immune system in some patients
3. New drug shows promise for those with clotting disorders: McMaster researcher
4. Congress Has Allowed Most Previous Medicare Cuts to Take Effect, New Study Shows
5. NYU Langone Medical Center Study Shows VNS Therapy is a Safe and Effective Treatment for Refractory Epilepsy
6. New Actuarial Analysis Shows Senate Bill Would Significantly Raise Premiums
7. New Hepatitis C Treatment Shows Promise
8. Report shows CIMT may improve arm use in children with hemiplegic cerebral palsy
9. Alcohol companies target youths with magazine ads, new study shows
10. Study shows modest improvement in advanced lung cancer overall survival rates
11. New Survey Shows Overwhelming Support Among Latinos for Health Care Reform That Includes Public Option
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... August 18, 2017 — Mediaplanet ... for active, healthy lifestyles and highlighting the importance of proactive eye and ear ... and shares the latest innovations in hearing aid technology. , According to ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Dawn Johnson Insurance Group, a ... charity drive to generate community support for efforts to educate the local population on ... for all types of cancer. , Each day in America, roughly 4,600 new ...
(Date:8/18/2017)... TX (PRWEB) , ... August 18, 2017 , ... ... assistance and financial planning services to communities in east Texas, is launching a ... Brain Tumor Foundation. , Founded in 1991, the Pediatric Brain Tumor Foundation (PBTF) ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... planning firm that serves residential and commercial clients in the greater Houston region, ... raise community support for the fight against cancer. , Founded by Tony and ...
(Date:8/18/2017)... Raton, Fl (PRWEB) , ... August 18, 2017 ... ... largest network of highly trained practitioners specializing in bioidentical hormone replacement therapy and ... associated with hormone imbalance and conditions of aging, such as menopause, andropause, thyroid ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), ... in Lakewood, Colorado . The reputable clinic ... Lipkin , PT, DPT with his staff of four clinicians. ... of Pittsburgh and brings over 10 years of experience with ... Belmar PT marks the 10th PRN clinic in and ...
(Date:8/7/2017)... GAITHERSBURG, Md. , Aug. 7, 2017 /PRNewswire/ ... for healthcare member acquisition, retention, and engagement, announced ... Director of Strategy and Product Development, effective as ... strategic consulting and technology implementation strategy for our ... years of experience in consulting and business analytics ...
(Date:8/7/2017)... Mich., Aug. 7, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), ... the quarter ended June 30, 2017.  All comparisons, unless otherwise ... Second Quarter 2017 Highlights ... to $1,089 million, an increase of 3.5% ... Gross margin of 7.5% versus 7.6% ...
Breaking Medicine Technology: