Navigation Links
Drug shows positive responses, low side-effects in multiple myeloma
Date:12/7/2009

NEW ORLEANS ― The second-generation proteasome inhibitor carfilzomib is showing noteworthy response rates and low levels of adverse side effects among multiple myeloma patients in a phase II clinical trial, researchers reported today at the 51st Annual Meeting of the American Society of Hematology.

The updated data from the 17-site study focuses on patients with relapsed or resistant multiple myeloma who have received one to three prior therapies, but not the drug bortezomib, the original proteasome inhibitor.

"These findings are truly an advance for patients with multiple myeloma," said Michael Wang, M.D., associate professor, Department of Lymphoma/Myeloma at M. D. Anderson and lead author on the study. "This is an incurable, challenging disease with devastating consequences.

"While new agents are extending life expectancies, they often have adverse side effects, including severe neuropathy. Carfilzomib is showing good response rates, with an improved side effects profile," Wang said. Neuropathy is peripheral nerve pain or numbness that can become debilitating enough to halt treatment.

According to the American Cancer Society, more than 20,000 cases of multiple myeloma will be diagnosed this year in this country. More than 10,000 people will die of this disease, which is a type of blood cancer.

Better tolerated than other agents

In preclinical studies carfilzomib has been better tolerated than bortezomib, allowing consecutive day dosing and treatment over extended periods of time. Both drugs work by targeting the cell's proteasome, which destroys mutated or damaged proteins. Blocking this process causes cell death. Carfilzomib targets and binds to the proteasome differently than bortezomib.

Researchers previously observed higher response rates to carfilzomib among patients who had never been treated with bortezomib compared to those with relapsed disease following bortezomib thera
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Concord Coalition Report Shows Eagerness for Reform, Readiness to Make Tough Choices on Fiscal Priorities
2. Bortezomib shows promise in reducing GVHD and reconstituting immune system in some patients
3. New drug shows promise for those with clotting disorders: McMaster researcher
4. Congress Has Allowed Most Previous Medicare Cuts to Take Effect, New Study Shows
5. NYU Langone Medical Center Study Shows VNS Therapy is a Safe and Effective Treatment for Refractory Epilepsy
6. New Actuarial Analysis Shows Senate Bill Would Significantly Raise Premiums
7. New Hepatitis C Treatment Shows Promise
8. Report shows CIMT may improve arm use in children with hemiplegic cerebral palsy
9. Alcohol companies target youths with magazine ads, new study shows
10. Study shows modest improvement in advanced lung cancer overall survival rates
11. New Survey Shows Overwhelming Support Among Latinos for Health Care Reform That Includes Public Option
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 28, 2015 , ... SmartPractice Calendars ... Personalized with practice contact information and logos, Calendars stand alone as functional brand-building ... Calendars into seasonal mailings, thank you and welcome communications, and to complement statements ...
(Date:8/28/2015)... ... 28, 2015 , ... SharkNinja, an innovative leader in the ... actress, Sofia Vergara, and unveil the Ninja® brand’s new coffee machine, the ... a variety of sizes and styles while achieving the perfect brew richness level ...
(Date:8/28/2015)... ... August 28, 2015 , ... Researchers ... comprehensive information on two new duals programs: Rhode Island Integrated Care Initiative, ... Idaho’s partnership to revamp Blue Cross of Idaho’s D-SNP. The database also ...
(Date:8/28/2015)... ... 28, 2015 , ... The Plaintiffs Steering Committee (PSC) and ... Replacement Therapy Products Liability Litigation, are in the midst of ongoing discussion regarding ... may receive for corporate employees involved in the production or marketing of AbbVie ...
(Date:8/28/2015)... ... ... Super-Sod launched their new website this summer. The new user-friendly site ... responsive web design. Website users will now have an improved browsing experience on their ... sign-up for the monthly turf-tips email, and find a local Super-Sod store all from ...
Breaking Medicine News(10 mins):Health News:SmartPractice® Introduces 2016 Calendars for Dental Practice Giveaways 2Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 2Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 3Health News:AIS Duals Database: August Update Finds Two New Duals Programs in Rhode Island and Idaho 2Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 2Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 3Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 4
... HealthDay Reporter , MONDAY, Sept. 5 (HealthDay ... may be creeping into the U.S. blood supply and ... researchers report. , Babesiosis is a parasitic infection that ... blood transfusion. Symptoms range from mild flu-like symptoms to ...
... University,s Mailman School of Public Health heightens concerns over ... of ubiquitous chemicals known as phthalates. Phthalates are a ... endocrine system, and are widely used in consumer products ... shampoos. Recent studies of school-age children have provided ...
... PAUL, Minn. Psychogenic non-epileptic seizures may go undiagnosed for much ... study published in the September 6, 2011, print issue of ... of Neurology. This type of seizure is different from seizures ... origin. "People with psychogenic seizures are often diagnosed with ...
... in a study published in the Archives of General Psychiatry ... serotonin (a brain chemical related to mood), may serve as ... stress disorder (PTSD) following a trauma. "One of ... at risk for developing the disorder following a trauma, while ...
... Reporter , MONDAY, Sept. 5 (HealthDay News) -- Growing ... vaccines, which could indicate that resistance to children,s inoculations ... getting better, but we still have a fair way ... immunization services division at the National Center for Immunization ...
... , MONDAY, Sept. 5 (HealthDay News) - Rudeness ... the workplace, a new study shows. Researchers from Baylor ... that stress home with them, which can have negative effects ... jobs. The researchers explained that when employees go home ...
Cached Medicine News:Health News:Tick-borne Illness May Lurk in Blood Supply 2Health News:Tick-borne Illness May Lurk in Blood Supply 3Health News:Prenatal exposure to phthalates linked to decreased mental and motor development 2Health News:Non-epileptic seizures may be misdiagnosed longer in veterans 2Health News:The search for predictors of risk for PTSD 2Health News:More U.S. 'Tweens' Getting Recommended Vaccines 2Health News:More U.S. 'Tweens' Getting Recommended Vaccines 3Health News:Boorish Co-Workers Can Damage Your Home Life 2
(Date:8/28/2015)... , Aug. 28, 2015 , ... Dr. Ra from Biostar , Published in ,Stem ... increase of lifespan through multiple IV administration of Adipose-derived ... and life expectancy found , Commercialization within 5 ... determined the possibility that adult mesenchymal stem cells (MSCs) ...
(Date:8/28/2015)... -- The global mHealth market ... 2020, growing at a CAGR of 47.6% from 2013 ... View Research, Inc. Monitoring services is expected to grow ... 2020.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... of chronic diseases such as cancer, heart ailments, and ...
(Date:8/27/2015)... WASHINGTON , Aug. 27, 2015 ... Collaborative (BPC) applauds the U.S. Food and Drug ... a distinguishable name in its draft guidance issued ... of biological products proposes distinguishable names, calling for ... includes an FDA-designated suffix. This proposal reflects the ...
Breaking Medicine Technology:Korean Researchers Find the Possibility that Adult Mesenchymal Stem Cells (MSCs) May Extend Lifespan 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2
... Dec. 5, 2011  At this week,s 46th Annual Midyear ... Health-System Pharmacists (ASHP), Cardinal Health launched BarCode360™ , ... making it easier, more timely and cost efficient to ... scanned at the patient bedside. ASHP has ...
... Pharmaceutical Co. Ltd, in which European healthcare venture capital ... as one of the Deloitte & Touche,s 50 top-performing ... the past three years. Beijing-headquartered GC-Rise, which ... revenues rising more than 270% on average per annum ...
Cached Medicine Technology:Cardinal Health Launches Innovative Barcode Administration Solution to Help Hospitals Bridge Gaps in Medication Safety 2Cardinal Health Launches Innovative Barcode Administration Solution to Help Hospitals Bridge Gaps in Medication Safety 3Women Health Expert GC-Rise Listed in Deloitte's 50 Top-performing Companies 2
Fine 2 mm wide platform. Cross action serrated handle with metal tip guard. Polished finish....
14 mm oval solid lower plate and straight 9 mm serrated upper jaw. Locking thumb screw and serrated handle with polished finish....
Oval solid 17 mm wide lower plate. Open upper plate with inside dimensions 12 mm x 14 mm. Serrated handle with locking thumb screw and polished finish. Most popular size or model....
Utrata-like fine angled tips with gently curved shaft for performing capsulorhexis through tunnel incisions. Dull finish. Round handle manufactured in titanium....
Medicine Products: