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Drug shows improved kidney function for type 2 diabetics, UT Southwestern researchers report
Date:6/24/2011

to maintain a slightly higher level of kidney function compared to baseline measurements taken at the study's start.

"That is important because it implies the beneficial effect of the drug lasts for quite some time after it is discontinued," Dr. Toto said.

The most common side effects included muscle spasms, low blood magnesium levels and nausea.

The next step, Dr. Toto said, will be a longer-term clinical trial with a larger patient pool, necessary to confirm the effectiveness and safety of using the anti-inflammatory in people with type 2 diabetes and chronic kidney disease. He noted that it is important to interpret the current study's results cautiously, given the small number of patients and one-year duration of the study.

"The results of this study show promise for bardoxolone methyl in the treatment of kidney disease in those with type 2 diabetes," he said. "If it's confirmed to be effective and safe in the long term, this drug could potentially have a major positive impact on kidney disease and become part of the standard of care."

Dr. Philip Raskin, professor of internal medicine who leads the University Diabetes Treatment Center and the diabetes clinic at Parkland Memorial Hospital, also participated in the study, as did researchers at Reata Pharmaceuticals, Renal Associates in San Antonio, the University of Alabama-Birmingham, and Statistics Collaborative in Washington, D.C.


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Contact: Jeff Carlton
jeffrey.carlton@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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