Navigation Links
Drug shows improved kidney function for type 2 diabetics, UT Southwestern researchers report

DALLAS June 24, 2011 A new anti-inflammatory drug used by patients with type 2 diabetes improved their kidney function during a year-long study involving researchers from UT Southwestern Medical Center.

The study findings, reported in today's New England Journal of Medicine, mark the first time a drug therapy has led to improved kidney function for patients with type 2 diabetes and chronic kidney disease. Previous studies have identified drugs that slowed the deterioration of kidney function, said Dr. Robert Toto, director of the Houston J. and Florence A. Doswell Center for the Development of New Approaches for the Treatment of Hypertension at UT Southwestern.

"In diabetes, kidney function tends to deteriorate over time," Dr. Toto said. "No prior studies of this duration have shown what appears to be an increase in kidney function by any therapy, which makes this a very exciting development."

Type 2 is the most common form of diabetes, the leading cause of kidney failure in the U.S. Diabetics account for nearly half of all new cases of end-stage renal disease, the point at which patients require dialysis or a kidney transplant, said Dr. Toto, professor of internal medicine.

The study involved 227 adult patients with type 2 diabetes and chronic kidney disease. They were divided into four groups three receiving different dosages of bardoxolone methyl, an anti-inflammatory drug, and the fourth group receiving a placebo and acting as a control.

The patients were tracked for 56 weeks, with measurements of their kidney function taken every four weeks. At study-highlighted weeks 24 and 52, researchers saw an overall significant increase in the estimated glomerular filtration rates, which are measurements of how well the kidneys are functioning, for the patients receiving the drug.

At 56 weeks, four weeks after researchers stopped administering the drug, a third measurement showed that patients continued to maintain a slightly higher level of kidney function compared to baseline measurements taken at the study's start.

"That is important because it implies the beneficial effect of the drug lasts for quite some time after it is discontinued," Dr. Toto said.

The most common side effects included muscle spasms, low blood magnesium levels and nausea.

The next step, Dr. Toto said, will be a longer-term clinical trial with a larger patient pool, necessary to confirm the effectiveness and safety of using the anti-inflammatory in people with type 2 diabetes and chronic kidney disease. He noted that it is important to interpret the current study's results cautiously, given the small number of patients and one-year duration of the study.

"The results of this study show promise for bardoxolone methyl in the treatment of kidney disease in those with type 2 diabetes," he said. "If it's confirmed to be effective and safe in the long term, this drug could potentially have a major positive impact on kidney disease and become part of the standard of care."

Dr. Philip Raskin, professor of internal medicine who leads the University Diabetes Treatment Center and the diabetes clinic at Parkland Memorial Hospital, also participated in the study, as did researchers at Reata Pharmaceuticals, Renal Associates in San Antonio, the University of Alabama-Birmingham, and Statistics Collaborative in Washington, D.C.


Contact: Jeff Carlton
UT Southwestern Medical Center

Related medicine news :

1. Menthol cigarettes marketed in predatory pattern, Stanford study shows
2. Study shows pine bark naturally improves heart function
3. Energy drinks linked to substance use in musicians, study shows
4. Study shows high prevalence and severity of childhood food allergy in the US
5. Black heart attack patients wait longer for advanced treatment, University of Michigan study shows
6. Glowing Hands Gel Shows Kids Where Dirt, Germs Linger
7. Medical debt occurs despite insurance, UA study shows
8. Etanercept shows promise for treating dermatomyositis
9. Heightened immunity to colds makes asthma flare-ups worse, U-M research shows
10. Ancestry plays vital role in nutrition and disease, study shows
11. New animal study shows promise for development of Parkinsons disease drug
Post Your Comments:
(Date:11/25/2015)... , ... November 25, 2015 , ... ... is offering lower prices in an early celebration of the early holiday shopping ... price of $29.95 each (normally $33.95 ea). Black Friday promotional pricing is in ...
(Date:11/24/2015)... ON (PRWEB) , ... November 24, 2015 , ... New ... Williams without a referral for dental implants at her Mississauga, ON practice. ... and experienced in the placement of dental implants. , Missing teeth can lead ...
(Date:11/24/2015)... ... ... In an article published November 12th by Obesity News Today, ... are not eligible for bariatric surgery. The article explains that candidates for weight loss ... pounds overweight, or have a BMI of 35 and over with at least two ...
(Date:11/24/2015)... ... November 24, 2015 , ... Preparing for the LDT Regulation:, ... p.m. EST, , FDA has long asserted that design and manufacture ... performing the tests and do not meet the device regulations. , Come up short ...
(Date:11/24/2015)... Richey, FL (PRWEB) , ... November 24, 2015 , ... ... deems a growing epidemic as deaths from prescription opioids in the United States grew ... and cocaine. In 2013 alone, opioids were involved in 37 percent of all fatal ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 ... global pharmaceutical company, and Rugen Therapeutics, a start-up ... treatments for unmet CNS disorders and funded by ... that they have entered into an exclusive collaboration ... therapies for Autism Spectrum Disorders (ASD) and Obsessive ...
(Date:11/25/2015)... Nov. 25, 2015  Mindray Medical ... MR ), a leading developer, ... worldwide, today announced that it will ... of shareholders at the Company,s Hong Kong office ... Prince Edward West Road, Mongkok KL, Hong ...
(Date:11/25/2015)... November 25, 2015 ... addition of the  "Global Drug Device ... to their offering.  --> ... of the  "Global Drug Device Combination ... their offering.  --> Research ...
Breaking Medicine Technology: