Navigation Links
Drug safety, efficacy, and potential new cancer biomarker predicted by NextBio
Date:10/14/2011

SANTA CLARA, CA (October 14, 2011): New research presented this week highlights the ability of NextBio to help life scientists and clinicians investigate publicly available genomic data to assess biological mechanisms underlying drug toxicity, as well as discover prospective cancer biomarkers for further validation. The unique capabilities of NextBio to search and make discoveries, not possible by other methods, from the massive amounts of genomic data increasingly available in the public domain is the subject of two poster presentations at the American Society of Human Genetics/International Congress of Human Genetics meeting in Montreal, October 11-15.

In one presentation, the authors showed how NextBio's web-based tools and integrative genomics data could be used to evaluate potential drug toxicities and suggest treatment alternatives for women experiencing "hot flashes" (vasomotor symptoms) as a result of breast cancer chemotherapy. In another presentation, NextBio authors demonstrated how genomic data from disparate sources could be brought together and analyzed on the NextBio platform to suggest a potential new cancer biomarker in a region of the genome previously termed a "gene desert."

Drug Toxicity, Alternative Therapy Identified by NextBio

NextBio analysis offers the potential to inform clinical medicine through its ability to predict drug toxicities, as illustrated by a study of tibolone, a drug widely used to treat menopausal vasomotor symptoms. In 2009, a clinical trial tested this drug as a potential therapy for similar symptoms in women undergoing breast cancer treatment. The trial was cut short early because of the significant increase in cancer recurrence observed in those women.

The authors' investigation of public genomic data curated by NextBio found positive correlations between tibolone-induced gene expression changes and those seen in breast cancer, as well as similarities to the gene expression profiles of estradiol hormone replacement therapy (HRT), which is contraindicated in patients with breast cancer. A similar analysis for gabapentin, another drug used to treat vasomotor symptoms, showed gene expression changes that are not correlated with breast cancer, HRT, or tibolone signatures, suggesting that gabapentin may offer a better alternative to tibolone for patients with breast cancer.

"Together, these and other analyses performed as part of this study demonstrate that NextBio's web-based tools and integrative genomics data can aid applications such as assessment of potential drug efficacy or adverse effects," said Helen Wang, NextBio scientist and lead author of the study.

Identification of Potential New Cancer Biomarker

A second study presented by NextBio showed how using genomic data curated from publicly available sources; researchers could perform in silico analysis to identify a possible new cancer biomarker in a portion of the genome previously known as a "gene desert".

Cellular changes involved in cancer are not unlike those involved in creating stem cells from adult tissues like skin. In both cases, cells re-gain the ability to multiply rapidly, and lose certain characteristics of adult, differentiated tissues. Analyzing data integrated from studies of genomic changes in stem cells with studies of several cancer types, the group identified a poorly characterized gene that was highly up-regulated in both cancer cells and stem cells, but not normal mature or otherwise differentiated cells.

"NextBio offers an unprecedented opportunity for life scientists to find correlations and make new findings from the rapidly rising mountains of publicly available genomic data, as well as from their own research results," said Ilya Kupershmidt, NextBio vice president of products. "As we enter the era of the $1000 genome, the NextBio platform can provide an important resource for analyzing and understanding genomic data from disparate sources, leading to new knowledge and the potential for better decision making for life science researchers, drug developers, and clinicians alike."


'/>"/>

Contact: Joan Kureczka
Joan@kureczka-martin.com
415-821-2413
Kureczka/Martin Associates
Source:Eurekalert

Related medicine news :

1. Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables
2. Society of Interventional Radiology addresses radiation safety, advances best practices
3. More doctors must join nurses, administrators in leading efforts to improve patient safety, outcomes
4. Critter Crossings Improve Highway Safety, Study Finds
5. Fortify HIT contracts with education and ethics to protect patient safety, say informatics experts
6. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
7. Lung cancer ALK rearrangement may predict pemetrexed efficacy, study shows
8. Evidence points to potential roles for cognitive rehabilitation therapy in treating traumatic brain injury, but further research needed
9. New potential therapeutic target for breast cancer
10. Polymeric material has potential for noninvasive procedures
11. The witch doctors gift: Potential new drugs from a cup of tea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... , ... Bellus Medical, a leader in medical aesthetics, recently ... of photodynamic cosmetics (PDC). , Allumera® is the first PDC cream specifically formulated ... and minimize the appearance of pores – all with minimal downtime and results ...
(Date:4/25/2017)... ... April 25, 2017 , ... A stressful work environment ... can also decrease overall productivity and performance in the workplace. The goal of Clearview ... the last few weeks of April, Clearview Resolution Services will be shutting down the ...
(Date:4/25/2017)... ... ... Lake Park Dental is now accepting new patients with crooked teeth who ... the help of this highly-effective, yet convenient system, patients can straighten their teeth and ... pain. , Drs. Sarah Jockin, Nicole Morganti, Sara Spear and Elizabeth Dy, of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Back Pain Centers of America (BPC), ... reputable physician in their area, announces the launch of a new and proprietary customer ... are looking for reputable physicians to help them with back or neck pain and ...
(Date:4/25/2017)... Ariz. (PRWEB) , ... April 25, 2017 , ... Emergency ... latest book of the Outlier Leadership Series, Outliers in Writing, set to publish in ... Professor of Emergency Medicine at the University of Arizona College of Medicine. He also ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... WARSAW, Ind. , April 20, 2017  Zimmer ... leader in musculoskeletal healthcare, today announced that it will ... Health Care Conference at the InterContinental Hotel in ... 2017.  Zimmer Biomet will present at 11:20 a.m. Eastern ... can be accessed via Zimmer Biomet,s Investor Relations website ...
(Date:4/20/2017)... WOONSOCKET, R.I. , April 20, 2017 /PRNewswire/ ... (NYSE: CVS), today unveiled a new store design ... new assortment of healthier food, health-focused products and ... the store to help customers discover new offerings. ... represent the next evolution of the customer experience ...
(Date:4/20/2017)... PARIS , April 20, 2017 ... EyeCET platform, the first non-viral gene expression technology that ... in the eye to address a wide range of ... UK Medicines and Healthcare products Regulatory Agency (MHRA) to ... ...
Breaking Medicine Technology: