Navigation Links
Drug reverses aging-associated changes in brain cells

Washington, DC -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study in the December 7 issue of The Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.

Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus. Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.

In the current study, Cui-Wei Xie, PhD, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) a protein that promotes synaptic plasticity and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals.

"These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

The researchers also found that treating the hippocampal tissue from older animals with a different drug that activates a BDNF receptor also reversed the synaptic plasticity deficit in the older rats. Because histone acetylation is important in many functions throughout the body, these findings offer a potential pathway to treat aging-related synaptic plasticity deficits without interfering with histone acetylation.

"It appears that lifelong shifts in gene regulation steadily deprive the brain of a key growth factor and cause a collapse of the 'machinery' supporting memory, cognition, and the viability of neurons," said Gary Lynch, PhD, a synaptic plasticity expert at the University of California, Irvine. "The very good news suggested by this study is that it may be possible to reverse these effects."

Contact: Kat Snodgrass
Society for Neuroscience

Related medicine news :

1. Vaccine Reverses Type 1 Diabetes in Mice
2. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
3. Heart damage improves, reverses after stem cell injections in a preliminary human trial
4. Breakthrough medical food reverses risk of heart disease and diabetes
5. Surgery-related weight loss in men reverses testosterone deficiency
6. Leukemia drug reverses tamoxifen-resistance in breast cancer cells
7. Physical Changes in Brain Linked to Altered Spirituality
8. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
9. Medicare Advantage Members May Make Changes During Open Enrollment
10. CMS Watch Changes Name to The Real Story Group
11. Changes during menopause increases risk of heart disease and stroke
Post Your Comments:
(Date:10/12/2015)... NJ (PRWEB) , ... October 12, 2015 , ... The ... programs and initiatives focused on improving public health and enhancing the quality of life ... will go to 11 New Jersey non-profit organizations. , The charitable arm of ...
(Date:10/12/2015)... ... October 12, 2015 , ... Advera Health Analytics, Inc . ... qualified Managed Care Organizations (MCOs) in order to provide health plans, payers, systems, and ... making process. In addition, the DSM is also being offered to healthcare media organizations ...
(Date:10/12/2015)... ... October 12, 2015 , ... A new invention has just been ... An inventor from Rutland, Mass., has modified a conventional nasal aspirator with child safety ... in withdrawing mucus from sinuses and nasal passages more safely and effectively than with ...
(Date:10/12/2015)... , ... October 12, 2015 , ... NFL football fans who are interested in having ... a great cause. CLICK HERE to donate to Smile for a Lifetime (S4L) ... to win an all-inclusive trip to the 2016 NFL Super Bowl! , Donors contributing $20.00 ...
(Date:10/12/2015)... York, NY (PRWEB) , ... October 12, 2015 ... ... Inc., Care to Care has secured a new corporate headquarters, located at 485 ... will allow for improved workflow and increased emphasis on cloud-based technology. , “Care ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... ) ... "Personalized Medicine, Targeted Therapeutics and Companion Diagnostic ... Industry Trends, Technologies, Participants, and Environment" ... ) has announced the addition of ... Companion Diagnostic Market to 2019 - Strategic ...
(Date:10/12/2015)... St. Paul, Minn. , Oct. 12, 2015 /PRNewswire/ ... with it, a need to help integrate these devices ... global leader of ergonomic healthcare mounting and mobility solutions, ... Carts, its lightest cart yet, for a wide array ... StyleView S-Tablet Cart SV10 was developed exclusively for Microsoft ...
(Date:10/12/2015)... 12, 2015 ... grow at 7.2% CAGR, microscopy market growth ... focus on nanotechnology, technological advancements, and increasing ... available with ... --> Complete report on microscopy ...
Breaking Medicine Technology: