Navigation Links
Drug reverses aging-associated changes in brain cells
Date:12/7/2011

Washington, DC -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study in the December 7 issue of The Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.

Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus. Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.

In the current study, Cui-Wei Xie, PhD, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) a protein that promotes synaptic plasticity and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals.

"These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

The researchers also found that treating the hippocampal tissue from older animals with a different drug that activates a BDNF receptor also reversed the synaptic plasticity deficit in the older
'/>"/>

Contact: Kat Snodgrass
ksnodgrass@sfn.org
202-962-4090
Society for Neuroscience
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vaccine Reverses Type 1 Diabetes in Mice
2. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
3. Heart damage improves, reverses after stem cell injections in a preliminary human trial
4. Breakthrough medical food reverses risk of heart disease and diabetes
5. Surgery-related weight loss in men reverses testosterone deficiency
6. Leukemia drug reverses tamoxifen-resistance in breast cancer cells
7. Physical Changes in Brain Linked to Altered Spirituality
8. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
9. Medicare Advantage Members May Make Changes During Open Enrollment
10. CMS Watch Changes Name to The Real Story Group
11. Changes during menopause increases risk of heart disease and stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... California (PRWEB) April 21, 2015 On ... Movie Awards” EcoLuxe Lounge at the world famous Avalon ... of sustainable product placement in TV and film, the ... makes appearances at many awards ceremonies and festivals throughout ... top providers of eco-friendly and socially conscious products and ...
(Date:4/21/2015)... The 2015 Market Research Report ... professional and in-depth study on the current state ... with a focus on the Chinese situation. ... market research are Cargill, Fbc Industries, Posy Pharmachem, ... Capchem, Lianyungang Mupro Fi, Yixing-Union, Debang Fine Chemical, ...
(Date:4/21/2015)... April 21, 2015 This year, in ... Skin Types, Inc.® (FIRST) will publish a unique awareness ... will run throughout the month of May and carry ... to Someone." The positioning was chosen to encourage ... skin disorder and to help support our mission of ...
(Date:4/21/2015)... Further strengthening ties between the two institutions, ... goods and services to the University of South Florida ... BRIDGE Healthcare Clinic. , The BRIDGE clinic – a ... year – provides primary medical care to more than ... inside the USF Health Morsani Center for Advanced Healthcare. ...
(Date:4/21/2015)... Approximately 75 million Americans live in areas ... Agency (EPA). On top of this, consuming alcohol and ... level of toxins found in the body. A natural ... is to increase consumption of broccoli. Considered by many ... glucoraphanin – a long-lasting antioxidant – of all cruciferous ...
Breaking Medicine News(10 mins):Health News:Hollywood's Santana Dempsey and Choices Recovery South Bend Examine Victory over Personal Struggles 2Health News:Sodium Citrate Industry Global Key Manufacturers Analysis Report 2015-2020 2Health News:Sodium Citrate Industry Global Key Manufacturers Analysis Report 2015-2020 3Health News:May is Ichthyosis Awareness Month. Use Your Voice. 2Health News:USF Health and Florida Hospital Tampa Partner to Expand BRIDGE Clinic 2Health News:USF Health and Florida Hospital Tampa Partner to Expand BRIDGE Clinic 3Health News:New Survey Shows Americans Are Cooking the Health Out of Broccoli 2Health News:New Survey Shows Americans Are Cooking the Health Out of Broccoli 3
... ,Coping With Unseen Injuries: From Battlefield to HomeFront, , , ... y Officers Association of America (MOAA) and the ... (USNI) will host a one-day Defense Forum Washington - "Coping With ... Hilton Alexandria Mark Center, 5000 Seminary Road in Alexandria, Va. Admiral Mike Mullen, USN, ...
... 2009 AMERIGROUP Corporation (NYSE: AGP ) will host an ... held at the Grand Hyatt Hotel in New York City. The ... 8:30 a.m. Eastern Time. , , To access ... Web site, www.amerigroupcorp . com , approximately ...
... , , , ... this time from the trading floor. While there has long been ... new research by the Kellogg School of Management at Northwestern University, ... of Chicago,s Department of Comparative Human Development explores how the hormone ...
... Experts recommend far fewer teaspoons a day than average person ... American women should not consume more than 100 calories ... intake to no more than 150 calories, according to a ... refers to sugars added to foods during processing, during cooking ...
... Questions Health Care Reform Benefits for Illegal Aliens, Supports Continued Immigration ... The Federation for American Immigration Reform (FAIR) announces September ... Their Feet to the Fire radio rally in ... 47 hosts, led by Roger Hedgecock of Radio America Networks and ...
... , , , ... Simmons firm, a leading national law firm in the fight against ... of the foremost trial attorneys in the country, has joined the ... tried dozens of asbestos cancer cases since the late 1970s. He ...
Cached Medicine News:Health News:Chairman of the Joint Chiefs of Staff to Discuss Wounded Warrior Issues at the USNI & MOAA 2009 Defense Forum Washington 2Health News:Chairman of the Joint Chiefs of Staff to Discuss Wounded Warrior Issues at the USNI & MOAA 2009 Defense Forum Washington 3Health News:Risky Business: New Study Explores Role of Gender, Testosterone in Financial Risk Aversion 2Health News:Risky Business: New Study Explores Role of Gender, Testosterone in Financial Risk Aversion 3Health News:Risky Business: New Study Explores Role of Gender, Testosterone in Financial Risk Aversion 4Health News:Americans Are Urged to Cut Sugar Intake 2Health News:Radio Talk Hosts Prepare for Broadcast Blitz Live From Washington. D.C. 2Health News:Decorated Trial Attorney Conard Metcalf Joins Simmons Firm as 'Of Counsel' 2Health News:Decorated Trial Attorney Conard Metcalf Joins Simmons Firm as 'Of Counsel' 3
(Date:4/21/2015)... CORAL SPRINGS, Florida , April 21, 2015 /PRNewswire/ ... in the U.S. are expected to grow at a ... for companies & vendors that provide technology services for ... Companies in focus today are: Surna Inc. (OTC: SRNA), ... (OTC: MJNA), Breathe, E-Cigs Corp. (OTC: BVAP), 22 nd ...
(Date:4/21/2015)... , April 21, 2015  Decision Diagnostics ... administrator and the exclusive worldwide sales, service and ... the FDA-cleared Green Alternative Strip, specifically designed to ... LifeScan OneTouch Ultra family of glucose testing meters, ... announced today that Johnson & Johnson/Lifescan has requested ...
(Date:4/21/2015)... , April 21, 2015  Navitas has launched ... a wide range of offerings for life sciences clients. ... an integrated platform enabling seamless flow of data across ... the Aviator launch, Navitas worked closely with Oracle to ... and Oracle,s CTMS in the Cloud. ...
Breaking Medicine Technology:New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 2New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 3New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 4New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 5New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 6New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 7Decision Diagnostics Shrugs Off New Attack As Johnson & Johnson Panics In Patent Case 2Decision Diagnostics Shrugs Off New Attack As Johnson & Johnson Panics In Patent Case 3Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 2Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 3Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 4
... Radial Microtome has a look that is revolutionary, ... of functions and capabilities that will please the ... of experience and knowledge but still breaking new ... Microtome will be the answer to many of ...
This is an economical (portable) microtome designed for fast and accurate sectioning. The specimen rise is automatic and accurate with each handle movement. Section thickness from 5 to 40 microns. ...
Coarse abrasive for knife sharpening, 6 grams net...
... Cryostage freezing stage is a refrigerated design for ... primarily for use with the 8000 sledge microtome, ... microtomes. ,The refrigerated stage gives a large working ... is ridged to provide good adhesion between the ...
Medicine Products: