Navigation Links
Drug rescues memory lost to Alzheimer's disease
Date:7/14/2009

Irvine, Calif., July 14, 2009 A drug similar to one used in clinical trials for treatment of rheumatoid arthritis and psoriasis has been found to rescue memory in mice exhibiting Alzheimer's symptoms.

The discovery by UC Irvine scientists offers hope that a new treatment may be on the horizon for people in the early stages of Alzheimer's, the leading cause of elderly dementia afflicting more than 5 million people in the U.S. and for which no cure exists.

The drug, called PMX205, prevented inflamed immune cells from gathering in brain regions with Alzheimer's lesions called amyloid plaques. Cell inflammation in these areas accelerates neuron damage, exacerbating the disease.

"We used a multidisciplinary approach combining an understanding of immunology and neurobiology to uncover a completely different target than other therapies," said Andrea Tenner, lead author of the study that led to the findings and a molecular biology & biochemistry professor at UCI.

Study results are reported in the July 15 edition of the Journal of Immunology.

For 12 weeks, Tenner and colleagues added PMX205 to the drinking water of mice genetically altered to develop age-related Alzheimer's-like symptoms. The treatment occurred at an age when plaques were accumulating in their brains.

Scientists gave the treated mice learning and memory tests and then examined their brains for evidence of the disease. Alzheimer's mice that were not given the drug performed significantly worse on the test than normal mice. But in all but one case the treated Alzheimer's mice performed almost as well as the normal mice. Those with the rescued cognitive ability had more than 50 percent fewer Alzheimer's lesions and inflammatory immune cells than the untreated diseased mice.

PMX53, a similar drug that can be taken orally, passed Phase 1 human clinical trials for safety with no major problems reported. Possible side effects include
'/>"/>

Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Petfinder.com Foundation Rescues 500 Shelters and Rescue Groups Nationwide with $1 Million Worth of Generators
2. Memory test and PET scans detect early signs of Alzheimers
3. Brown professor continues debate over recovered memory
4. More Evidence That Caffeine Can Jolt Memory
5. Caffeine reverses memory impairment in Alzheimers mice
6. On Memory, Older Americans Outsmart the English
7. Sleep May Be Essential for Long-Term Memory
8. Transplant drug stimulates immune memory
9. Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
10. Depression may increase Alzheimers risk in people with memory problems
11. Penn study demonstrates new way to boost immune memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... September 20, 2014 The excitement is building up ... Airy, North Carolina. This year the Surry Arts Council will ... from around the country who are still fans of the Andy ... a sitcom that aired on CBS from 1960 through 1968. ... in American television history. Mount Airy, North Carolina is where ...
(Date:9/20/2014)... 20, 2014 Recently, UWDress.com, an innovative ... women’s special occasion outfits, has launched a special offer ... prom outfits are popular among worldwide clients. Now, all ... prom dresses on its website. , Additionally, ... from around the world. Great custom made items can ...
(Date:9/20/2014)... Wisconsin (PRWEB) September 20, 2014 QueenBeeTickets.com ... the young star’s tour performances. She will visit many ... of February until the 16th of April. , ... Grande Honeymoon Tour tickets at QueenBeeTickets.com. , The star’s ... opportunity to see their favorite young singer in a ...
(Date:9/20/2014)... The Arizona Advanced Manufacturing Institute ... Manufacturing Day by opening its doors to the community. ... manufacturing labs will be offered between 10 a.m. and ... and Dobson campus (1833 W. Southern Ave, Mesa, AZ ... The AzAMI at MCC was established in the fall ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 MarijuanaDoctors.com ... successful showing at the PAIN Week conference that ... Hotel and Casino in Las Vegas from September ... primarily attended PAIN Week in the hopes of ... a viable and legitimate tool to treat chronic ...
Breaking Medicine News(10 mins):Health News:Mayberry Days Parade Cars will be Provided by Mount Airy Toyota and Mount Airy Chrysler Dodge Jeep Ram 2Health News:Discounted 2014 Prom Dresses Provided By Innovative Company UWDress.com 2Health News:Discount Ariana Grande Tickets: QueenBeeTickets.com Delights Fans with Discount Concert Tickets for Ariana Grande’s 2015 Honeymoon Tour 2Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2Health News:MarijuanaDoctors.com Experiences Unprecedented Support and Growth at Pain Week 2014 2
... 1 As the economic crisis deepens, SilverCensus.com ... a national web site for caregivers, senior citizens, ... urging American Veterans to investigate and take advantage ... called "Aid and Attendance." ...
... Mass., April 1, EnVivo Pharmaceuticals today ... Corporation (MTPC) for the development and commercialization ... Japan and several other Asian countries. EVP-6124 ... agonist currently in development for cognition enhancement ...
... Laboratories, Inc. Immunotech Laboratories announces successful Participation in ... its abstract " Irreversible Pepsin Fraction (IPF) displays ... in vitro investigation of activity on human lymphocytes." ... Conference on Clinical and Social Research on AIDS ...
... worse cholesterol, blood vessel health than with South Beach, Ornish ... the "maintenance" phase that occurs after initial weight loss, the ... on the heart than the high-fat, low-carbohydrate Atkins regimen, a ... diets to see which might be better at achieving weight ...
... April 1 Harvest Technologies Corp. ... study report was completed for the first thirty (30) ... non-reconstructable critical limb ischemia due to advanced thromboangitis obliterans, ... is being conducted at Sri Ramachandra University in Chennai ...
... VC Business Practices to Funding ResearchTUCSON, Ariz., April 1 ... launch of a new initiative, MDA Venture Philanthropy (MVP), ... A 501(c)(3) nonprofit organization, MVP will break with traditional ... of venture capital firms to fast track the development ...
Cached Medicine News:Health News:Little-Known VA Care Entitlement for Veterans Highlighted by SilverCensus.com 2Health News:Little-Known VA Care Entitlement for Veterans Highlighted by SilverCensus.com 3Health News:EnVivo and Mitsubishi Tanabe Enter License Agreement on EVP-6124 in Japan, Korea, Taiwan and Other Asian Countries 2Health News:EnVivo and Mitsubishi Tanabe Enter License Agreement on EVP-6124 in Japan, Korea, Taiwan and Other Asian Countries 3Health News:Beating a Global Killer: HIV/AIDS 2Health News:Beating a Global Killer: HIV/AIDS 3Health News:Beating a Global Killer: HIV/AIDS 4Health News:Atkins Diet Tougher on Heart After Weight Loss 2Health News:Atkins Diet Tougher on Heart After Weight Loss 3Health News:Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial in Chennai India 2Health News:Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial in Chennai India 3Health News:Muscular Dystrophy Association Launches New Venture Philanthropy 2Health News:Muscular Dystrophy Association Launches New Venture Philanthropy 3
(Date:9/19/2014)... EASTON, Mass. , Sept. 19, 2014 /PRNewswire/ ... "Company") today announced it has received and approved ... Barozyme HT48 instruments and has begun to manufacture ... the first instrument will be ready for shipment ... be built and released at a rate of ...
(Date:9/19/2014)... 2014  BioSpecifics Technologies Corp. (NASDAQ: BSTC ), ... as XIAFLEX ® in the U.S. and XIAPEX ® ... Tom Wegman , will present a corporate overview at the ... Conference. The presentation will take place on ... Millennium Broadway Hotel in New York, NY ...
(Date:9/19/2014)... LONDON , September 19, 2014 ... hat Pharma IQ den äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, ... abdeckt. Die interaktive PDF, verfügbar unter pharmaserialisation.com ... an dem sie jeweils in Kraft treten. ... der Serialisierung nicht länger um das "ob", sondern ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2
... May 20 BioMarin,Pharmaceutical Inc. (Nasdaq and SWX: ... treatment in the Phase 1 clinical study of ... of,phenylketonuria (PKU). The study is expected to conclude ... are dedicated to serving the PKU community and ...
... Claims Suggests a Benefit,of Anti-Tumor Necrosis Factor Therapies on Absenteeism Among ... ... Data from a new analysis of the,Active Ulcerative Colitis Trials (ACT ... percent of patients with moderately to severely active,ulcerative colitis (UC) receiving ...
Cached Medicine Technology:BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU 2BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU 3New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 2New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 3New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 4New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 5New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 6New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 7New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 8
Contoured waterfall-front ergonomic seats and generous backrests with lumbar support are standard on these ergonomic chairs. • With casters • With Tubular Base....
Inquire...
The model 55D Rocking Shaker provides the same Reliable quality as the 55S, but double the value. The 55D gives you an additional platform with a height of 3.25 in....
... The model 55S Rocking Shaker ... gels and blotted membranes. The very ... adjustable degree of tilt provide a ... washes over gels and blotted membranes ...
Medicine Products: