Navigation Links
Drug rescues memory lost to Alzheimer's disease
Date:7/14/2009

Irvine, Calif., July 14, 2009 A drug similar to one used in clinical trials for treatment of rheumatoid arthritis and psoriasis has been found to rescue memory in mice exhibiting Alzheimer's symptoms.

The discovery by UC Irvine scientists offers hope that a new treatment may be on the horizon for people in the early stages of Alzheimer's, the leading cause of elderly dementia afflicting more than 5 million people in the U.S. and for which no cure exists.

The drug, called PMX205, prevented inflamed immune cells from gathering in brain regions with Alzheimer's lesions called amyloid plaques. Cell inflammation in these areas accelerates neuron damage, exacerbating the disease.

"We used a multidisciplinary approach combining an understanding of immunology and neurobiology to uncover a completely different target than other therapies," said Andrea Tenner, lead author of the study that led to the findings and a molecular biology & biochemistry professor at UCI.

Study results are reported in the July 15 edition of the Journal of Immunology.

For 12 weeks, Tenner and colleagues added PMX205 to the drinking water of mice genetically altered to develop age-related Alzheimer's-like symptoms. The treatment occurred at an age when plaques were accumulating in their brains.

Scientists gave the treated mice learning and memory tests and then examined their brains for evidence of the disease. Alzheimer's mice that were not given the drug performed significantly worse on the test than normal mice. But in all but one case the treated Alzheimer's mice performed almost as well as the normal mice. Those with the rescued cognitive ability had more than 50 percent fewer Alzheimer's lesions and inflammatory immune cells than the untreated diseased mice.

PMX53, a similar drug that can be taken orally, passed Phase 1 human clinical trials for safety with no major problems reported. Possible side effects include
'/>"/>

Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Petfinder.com Foundation Rescues 500 Shelters and Rescue Groups Nationwide with $1 Million Worth of Generators
2. Memory test and PET scans detect early signs of Alzheimers
3. Brown professor continues debate over recovered memory
4. More Evidence That Caffeine Can Jolt Memory
5. Caffeine reverses memory impairment in Alzheimers mice
6. On Memory, Older Americans Outsmart the English
7. Sleep May Be Essential for Long-Term Memory
8. Transplant drug stimulates immune memory
9. Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
10. Depression may increase Alzheimers risk in people with memory problems
11. Penn study demonstrates new way to boost immune memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post explaining ... smokers. , Smoking will always have a negative impact ... best method to find affordable coverage. Insurance brokerage websites ... , Whole life insurance premiums will be fixed ... coverage is permanent, the initial rates are very ...
(Date:10/1/2014)... 01, 2014 Join the more than 80 ... Treatment Center’s first ever charity golf tournament to benefit Project ... eating disorders who cannot afford treatment. The tournament will be ... Eureka, Mo. , The day-long event starts with 10:30 ... and award dinner will begin at 5 p.m. and will ...
(Date:10/1/2014)... 01, 2014 Diet Doc understands that many ... lose weight and their dieting attempts could be easily sabotaged ... hormone diet treatments into their programs as a ... see fast and effective weight loss results, it also allows ... habits to maintain their weight for the future. , Earlier ...
(Date:10/1/2014)... occasion of the Leishmaniasis East Africa Platform meeting, ... leishmaniasis experts, results of a pharmacovigilance or ... carried out by MSF, DNDi, and national partners ... to key decision makers in order to boost ... combination of Sodium Stibogluconate and Paromomycin (SSG&PM) in ...
(Date:10/1/2014)... Today marks the final day prosthodontist Dr. ... Oxnard and Woodland Hills, Calif., is in the southern ... , “Speaking to this group of specialists allows more ... the help and care they deserve,” Dr. Jivraj said. ... work, providing cosmetic dentistry, correcting bite issues, placing implants, ...
Breaking Medicine News(10 mins):Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... ... Facebook group regarding the McNeil Consumer Healthcare recall have drafted a downloadable ... Senators. This letter details unanswered questions of concerned parents as McNeil ... of children,s and infant,s Tylenol, Motrn, Zyrtec and Benadryl. This letter ...
... ... Office-LinX 7.1 Recognized for Exceptional Innovation, , ... Richmond Hill, ON (PRWEB) May 7, 2010 ... 7.1 as a recipient of its 2009 Unified Communications magazine Product of the ...
... , ... Healthcare professionals informed of every milestone leading to regulatory approval for,Alair® and Provenge®, ... ... and consulting company, announces the release of two reports on first-of-a-kind technologies just ...
... of Assisted Living Facilities (ALFs) in Los Angeles showed that ... was associated with declining quality of life and increased depression ... published today in the Journal of the American Geriatrics ... they are unable to live independently, but do not require ...
... risk by up to 40 percent, researchers say , THURSDAY, ... role triglyceride levels might play in heart disease, and finally ... fat to an increased risk of heart trouble. , ... disease prevention efforts, but experts say a new report ...
... National Institutes of Health (NIH) has awarded a $2.7-million ... project with Case Western Reserve University School of Nursing, ... Medical Center in Cleveland to study cognitive impairment in ... Heart, Lung, And Blood Institute runs through Jan. 31, ...
Cached Medicine News:Health News:Facebook Group for McNeil Product Recall Organizes Letter Writing Campaign – Urges Concerned Parents to Contact House of Representatives and Senators 2Health News:Esna Technologies Receives Unified Communications Magazine's 2009 Product of the Year Award 2Health News:Esna Technologies Receives Unified Communications Magazine's 2009 Product of the Year Award 3Health News:Esna Technologies Receives Unified Communications Magazine's 2009 Product of the Year Award 4Health News:Hayes, Inc. Technology Prognosis Team Tracks First-of-a-Kind Technologies 2Health News:Older people in assisted-living facilities sleep poorly 2Health News:Genes Tie Blood Fat to Heart Disease 2Health News:Genes Tie Blood Fat to Heart Disease 3Health News:NIH awards $2.7-million grant to Kent State to study cognitive impairment in heart failure patients 2Health News:NIH awards $2.7-million grant to Kent State to study cognitive impairment in heart failure patients 3
(Date:9/30/2014)... 30, 2014  Wrightington, Wigan ... MDRX ) are delighted to announce WWL,s ... new health information system. The system will be implemented ... the way WWL delivers healthcare in the future. ... record of on-time and on-budget system implementations as well ...
(Date:9/30/2014)... LONDON , Sept. 30, 2014 ... conducting this study is to provide an overview ... global market for protein drugs/therapeutics. The key objective ... direction of protein drugs as an important tool ... report explores present and future strategies within the ...
(Date:9/30/2014)... DENVER , Sept. 30, 2014  According ... "the world of cancer clinical trials is going ... clinical trials and the work of the current ... these types of ,next generation, clinical trials, which ... tomorrow."  The company has been ...
Breaking Medicine Technology:Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 2Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 3Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 4Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2
... THOUSAND OAKS, Calif., Jan. 7 Amgen (Nasdaq: AMGN ... Healthcare Conference at 8:00 a.m. Pacific Time on Tuesday, Jan. ... Calif. Amgen Chairman and CEO Kevin Sharer will present ... available over the Internet and can be accessed from Amgen,s ...
... Ariz., Jan. 7 The Providence Service Corporation (Nasdaq: ... Executive Officer, is scheduled to present an overview of the Company,s ... on Monday, January 11, 2010 at The Grand Hyatt Hotel in ... ET. , On Thursday, January 14, 2010, Mr. McCusker ...
Cached Medicine Technology:Amgen to Present at the 28th Annual JP Morgan Healthcare Conference 2Providence Service Corporation to Present at the Sidoti & Company, LLC Micro Cap Conference on Monday, January 11th and at the CJS Securities 'New Ideas for the New Year' Conference on Thursday, January 14th 2
... objective and high power negative lens delivering ... true benefit of this system is ease ... is made possible due to a superior ... bar and individual interpupillary adjustment provides stability ...
23 gauge thin wall irrigation. 25 gauge thin wall aspiration. Angled 30 degree shaft 8 mm from tip to bend. Irrigation tip set 0.5 mm behind aspiration tip. Dual hub construction. Polished finish. Ov...
This specially designed 23 gauge spoon-shaped cannula is connected to a balanced salt solution bottle and with a low-flow of fluid, is designed to allow a controlled cleaning of the stromal interface...
... five legs for extra stability. Adjustable height ... travel 6"). 2" ball bearing swivel hard ... upholstery, available in black vinyl as standard, ... a contoured, padded, upholstered backrest, with vertical ...
Medicine Products: