Navigation Links
Drug reduces the increase in fear caused by previous traumatic experiences in mice
Date:1/12/2011

Mice previously exposed to traumatic situations demonstrate a more persistent memory of fear conditioning - acquired by associating an acoustic stimulus with an aversive stimulus - and lack the ability to inhibit this fear. This phenomenon is similar to that of people who suffer from Post-Traumatic Stress Disorder (PTSD), an anxiety disorder which appears after being exposed to highly traumatic situations, such as a violent attack, a natural disaster or physical abuse.

In the study researchers verified that the 7,8-Dihydroxyflavone injected into mice previously subjected to a traumatic experience made them extinguish fear conditioning quicker. The enhancement of this new learning is the result of 7,8-Dihydroxyflavone activating the TrkB receptors in the brain, probably those found in the amygdala, which are essential for emotional learning and memory.

7,8-dihydroxyflavone is a type of flavonoid. These chemical compounds are present in our diets in elements such as red wine, citrus, cereals, tea and chocolate (at least 70% cocoa), etc. Chronic administration of foods rich in flavonoids in lab animals has demonstrated neuroprotective effects in aged rodents, but the activation of TrkB receptors produced by these foods is surely low compared to the effects of 7,8-Dihydroxyflavone.

TrkB receptors in the brain are activated in mammals by the BDNF protein. There are different pathologies, such as depression or anxiety disorders, in which this protein shows alterations in its function. Unfortunately, administration of the BDNF protein as a drug is limited given that a large part of the amount injected does not permeate the blood-brain barrier and cannot access the brain. Very recent studies have demonstrated that 7,8-Dihydroxyflavone is the first drug to imitate BDNF actions and enter the brain with much more efficacy than the protein, thus revealing therapeutic actions in animal models suffering from Alzheimer's, strokes, Parkinson's and/or depression.

The results obtained in this study postulate that 7,8-Dihydroxyflavone as a drug could be an useful treatment for disorders based on fear such as PTSD, panic attacks and phobias. Researchers consider it convenient to study its effects combined with psychotherapy, administering the drug in fear extinction therapy sessions for anxiety disorders or even shortly after a person experiences a traumatic situation.


'/>"/>

Contact: Antonio Armario
Antonio.Armario@uab.cat
34-935-811-840
Universitat Autonoma de Barcelona
Source:Eurekalert

Related medicine news :

1. Loss of gene promotes brain-tumor development, reduces survival, study finds
2. Study shows that CPAP therapy reduces fatigue, increases energy in patients with sleep apnea
3. Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent
4. Annual breast cancer screening beginning at age 40 reduces mastectomy risk
5. Regular exercise reduces large number of health risks including dementia and some cancers
6. Canola-type rapeseed oil reduces the level of fibrinogen, a cause of thrombosis and inflammation
7. National study shows CT screening of former, current smokers reduces lung cancer deaths
8. Cancer drug linked to quantum dots increases drug uptake, reduces inflammation
9. PSA Test Reduces Risk of Spread if Prostate Cancer Strikes
10. Studies show everolimus-eluting stent implantation reduces restenosis and repeat revasculariztion
11. Vigorous exercise reduces breast cancer risk in African-American women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... 2016  Collagen Matrix, Inc., ("Collagen Matrix") the ... of collagen and mineral based medical devices for ... Bill Messer has joined the company as ... the growing portfolio of oral surgery, neurosurgery, orthopaedic ... joins the Collagen Matrix executive team as an ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
Breaking Medicine Technology: