Navigation Links
Drug prevents bone loss side effects of breast cancer medication
Date:10/9/2011

A new study has found that an osteoporosis drug protects against the bone damaging side effects of certain breast cancer medications. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study indicates that some breast cancer patients could take zoledronic acid in addition to their anti-cancer medications to maintain bone health.

Drugs called aromatase inhibitors stop the production of estrogen in postmenopausal women and therefore make less estrogen available to stimulate the growth of certain breast cancer cells. Many postmenopausal women with breast cancer are routinely treated for several years with these potentially life-saving drugs, but the agents can cause bone loss and fractures.

Adam Brufsky, MD, PhD, of the University of Pittsburgh Cancer Institute, and his colleagues conducted a study to see if the bone drug zoledronic acid could prevent and treat bone loss in postmenopausal breast cancer patients. In their five-year study, called Z-FAST, 602 postmenopausal women with early breast cancer who were receiving the aromatase inhibitor letrozole were randomized to receive zoledronic acid simultaneously with letrozole or only after bone loss or fractures occurred.

The investigators observed significant and progressive increases in bone density throughout the five years of the study in women who initiated zoledronic acid at the start; in contrast, significant decreases in bone density occurred when zoledronic acid administration was delayed until bone loss was apparent. Over time, though, the rate of bone density decline in the delayed group slowed, most likely because more delayed patients received zoledronic acid by the end of the study. These findings indicate that bone density is maintained more effectively with upfront zoledronic acid, but bone loss is likely reversible so that initiating zoledronic acid, even after bone loss has developed, is beneficial.

"This study shows that bone loss from aromatase inhibitors can be prevented long term with a safe and effective drug that prevents osteoporosis," said Dr. Brufsky. Zoledronic acid is currently approved by the U.S. Food and Drug Administration for conditions including osteoporosis and bone complications of cancer.


'/>"/>

Contact: Jennifer Beal
healthnews@wiley.com
44-124-377-0633
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Knockout of protein prevents colon tumor formation in mice
2. Marijuana administration after a traumatic experience prevents post-traumatic stress symptoms
3. Adding a stent during minimally invasive surgery to repair aneurysms prevents recurrence
4. Tai Chi Prevents Falls, Boosts Mental Health in Seniors: Study
5. UNC-led study shows early treatment with antiretroviral therapy prevents HIV transmission
6. Tobacco-derived compound prevents memory loss in Alzheimers disease mice
7. Early infusion of donor T cells prevents graft versus host disease in blood cancer patients
8. Tomatoes found to contain nutrient which prevents vascular diseases
9. Finnish researchers find a compound that prevents the growth of prostate cancer cells
10. Researchers establish new rule to predict risk of stroke, death from surgery that prevents it
11. New discovery prevents symptoms of rare genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... Horeb, WI (PRWEB) , ... March 29, 2017 , ... ... patients on early orthodontic treatment and accepting new pediatric patients, with or without a ... help young patients have a better orthodontic outcome and experience. When patients receive early ...
(Date:3/29/2017)... ... March 29, 2017 , ... An inventor ... "The rubber bands used in conjunction with my braces always rubbed against the ... a way to prevent this problem." The O.B.S. was the result of his ...
(Date:3/29/2017)... ... March 29, 2017 , ... Patients ... access to the robotic-assisted total-hip and partial-knee replacement surgeries that are offered ... Forbes Hospital and Jefferson Hospital recently started performing these surgeries using the ...
(Date:3/28/2017)... ... March 28, 2017 , ... A recent Bellwether Education Partners’ ... the field must first improve teacher preparation program design. It then asserts that ... that decades of input- and outcome-based research has failed to improve teacher education. ...
(Date:3/28/2017)... ... March 28, 2017 , ... Resoundant, ... be invited to the Siemens Healthineers annual customer education symposium, a world-class learning ... take place from March 27 - 31, 2017 at the Atlanta Marriott Marquis ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017 On March 28, the U.S. Food and Drug ... relapsing forms of multiple sclerosis (MS) and primary progressive ... by the FDA for PPMS. Ocrevus is an intravenous ... "Multiple sclerosis can have a profound impact on ... director of the Division of Neurology Products in the ...
(Date:3/29/2017)... March 29, 2017 /PRNewswire/ - Medicure Inc. ("Medicure") (TSXV:MPH, ... results for the year ended December 31, 2016 ... The results are being released later than the ... will include the operations and balances of Apicore ... This release and filing date meets TSX Venture ...
(Date:3/29/2017)... DUBLIN , Mar. 29, 2017 Research ... Safety and Risk Management Software Market Outlook: 2016-2022" report to ... ... segmented by product, mode of delivery, end-user, and geography. ... healthcare systems across the globe. The field has developed significantly in ...
Breaking Medicine Technology: