Navigation Links
Drug potency -- what happens in space?
Date:4/14/2011

Some of the Pharmaceuticals intended for the treatment of minor illnesses of astronauts in space may require special packaging and reformulation to remain stable for long periods in the space environment. That's according to Dr. Putcha and her colleagues from NASA, Johnson Space Centre. Their findings, published online in The AAPS Journal suggest that some of the pharmaceuticals stored on space flights may have shorter shelf-life than they do on Earth.

Pharmaceuticals used on space flights are packed and dispensed in special flight-certified containers and stored in compact flight kits. They may be exposed to the unique environ-mental factors of space missions such as radiation and excessive vibration in addition to variations in temperature and humidity.

Scientists at the Johnson Space Centre investigated whether pharmaceuticals undergo degradation in space and, if so, which environmental variables in space may affect the stability of the medications in space. They compared physical and chemical changes in 35 formulations contained in identical pharmaceutical kits stowed on the International Space Station (ISS) and on Earth.

After stowage for 28 months in space, they found that a higher percentage of the medica-tions from each flight kit had a lower active pharmaceutical content than the controls on the ground. They also saw no variation in the temperature or humidity levels between Earth and in space.

Putcha and her colleagues suggest that exposure to the chronic low dose of ionizing radi-ation as well as repackaging of solid medications may be contributing factors for phar-maceutical stability in space.

The authors conclude: "It is important to characterize space-specific degradation products and toxicity limits using ground-based analogue environments of space that include proton and heavy ion radiation, vibration and multiple gravity conditions. This information can facilitate research for the development of space-hardy pharmaceuticals and packaging technologies."


'/>"/>

Contact: Renate Bayaz
renate.bayaz@springer.com
49-622-148-78130
Springer
Source:Eurekalert

Related medicine news :

1. Global Warming Increases The Potency Of Poison Ivy and Natural Antidotes
2. Amniotic fluid cells more efficiently reprogrammed to pluripotency than adult cells
3. What Happens When Kids Born Blind Gain Sight?
4. Simple spit and blood tests might detect burnout before it happens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... ... with the American Society of Anesthesiologists® (ASA®), the Foundation for Anesthesia Education ... of Orthopaedic Surgeons (AAOS) and the Cigna Foundation, encourages proposals supporting high ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... education programs and resources at seafoodnutrition.org/programs and seafoodnutrition.org/resources to assist in teaching ... diet. These resources have been developed for use by nutrition educators and ...
(Date:1/22/2017)... ... 22, 2017 , ... Phytocéane invites clients to take an exotic journey deep ... with ZANZIBAR MILKY CREAM. Inspired by the beauty of Zanzibar, a Tanzanian archipelago off ... moisturizing vegetal coral to create this gentle, velvety body cream to envelop the skin ...
(Date:1/21/2017)... ... January 21, 2017 , ... Caronlab Australia, an Australian company ... ECRM Trade Show in Hilton Head, SC, where it benefited from outstanding meetings with ... of its beauty and wellness products. At this trade show, the company had the ...
(Date:1/21/2017)... ... , ... Phytocéane invites you to take an exotic journey deep ... with ZANZIBAR SHOWER GEL. Inspired by the beauty of Zanzibar, a Tanzanian archipelago off ... vegetal coral to create this gentle, crystal-clear shower gel to cleanse the body and ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Varias proteínas clave que ... y el riesgo de diálisis están poco ...    Resverlogix Corp. ("Resverlogix" o "la compañía") ... ensayo en fase 1 con sede en Nueva Zelanda ... Los datos demostraron unos resultados importantes en la reducción ...
(Date:1/23/2017)... , January 23, 2017 The global  anxiety disorders ... billion by 2025. The rising incidence of depression worldwide is anticipated to drive ... has resulted in the declining demand for antidepressants in the recent years. ... ... Grand View Research Logo ...
(Date:1/23/2017)... 23, 2017 InDex Pharmaceuticals Holding AB (publ) ... 12th congress of the European Crohn,s and Colitis Organisation (ECCO). The ... specific focus on inflammatory bowel disease (IBD). The congress is held ... ... pleased to again having been selected to present data at the ...
Breaking Medicine Technology: