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Drug makes leukemia more vulnerable to chemo
Date:3/20/2012

h leukemic cells."

In 2009, DiPersio and his colleagues showed that this concept worked in mice with a form of AML. Mice treated with plerixafor plus chemotherapy had improved survival over mice treated with chemotherapy alone. But DiPersio says plerixafor targets only one of many tethers anchoring these cells to the bone marrow.

"This is one of the first clinical examples of targeting the environment that leukemia cells live in," DiPersio says. "In the future, we may find other drugs, or combinations of drugs, that work better. There are now a number of groups around the world putting together similar approaches."


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Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

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