Navigation Links
Drug makes leukemia more vulnerable to chemo
Date:3/20/2012

are addicted to in this case, the relatively normal environment of the bone marrow."

DiPersio calls the results of this study encouraging and worthy of additional exploration.

"If these results are repeated in a larger study, it would be transformative," he says. "It would change the standard way we treat these patients we would use this approach with everybody. In addition, the approach of targeting the tumor microenvironment could also be exploited for the treatment of other hematologic and solid tumor malignancies."

Bone marrow protects leukemia cells by inhibiting the cell-suicide response that might otherwise lead AML cells to self-destruct. Although leukemia cells in the bone marrow do not rapidly divide, their stability makes them very resistant to treatment. And while chemotherapy can clear the bloodstream of leukemia for a period of time, these "protected" cells in the bone marrow may cause the cancer to return.

The drug used in this study, called plerixafor, blocks the leukemia cells from attaching to the bone marrow. Released from their protective environment into the bloodstream, the cells lose the bone marrow's survival signals and begin to divide. Rapidly dividing cells are more sensitive to chemotherapy.

Plerixafor received approval from the U.S. Food and Drug Administration in 2008 for use prior to a stem cell transplant to treat patients with two other types of blood cancers: multiple myeloma and non-Hodgkin's lymphoma. In these diseases, plerixafor is used to dislodge normal stem cells from the bone marrow. Once in the bloodstream, those stem cells can then be collected for a transplant. Returning the patient's own stem cells after aggressive chemotherapy is a standard treatment for these two cancers.

"We helped in plerixafor's development for stem cell mobilization," DiPersio says. "So we thought if it makes normal stem cells leave the bone marrow to circulate, maybe it would do the same wit
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Adapting to clogged airways makes common pathogen resist powerful drugs
2. Wedding Band Makes Jealousy a Bigger Threat
3. New Online Store Makes Buying Cosmetics a Healthy Choice
4. AARP Makes Senate Vote on Idaho Health Freedom Act Accountability Vote
5. Parkinsons disease makes it harder to figure out how other people feel
6. Psychosurgery makes gentle comeback
7. Locum Tenens Staffing Firm Makes Inavero's 2010 Best of Staffing List
8. New Gender-Neutral Flex-Friendly Certification Makes the Business Case for Flex Even in a Tough Economy.
9. Zenger Folkman Makes 2010 Top 20 Leadership Training List
10. Healthy food makes consumers feel hungrier when choices are limited
11. IRS Whistleblower Office Makes Good Again: Kenney & McCafferty Whistleblowers Receive Full Reward
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 27, 2015 Allred Dental located in San ... - who need extensive dental treatment - understand the oral ... customized for their problems. , Dr. Jeff Allred calls it ... of the assessment of the patient’s oral health and problems ... treat their oral health problems. , “The dental case planning ...
(Date:5/27/2015)... New Hampshire (PRWEB) May 27, 2015 ... in the April 2015 issue of the Journal of ... diet sodas and abdominal obesity, Bedford Commons OB-GYN ... water instead of non-nutritive sweetener-flavored beverages. , To ... waist circumference, a comprehensive San Antonio Longitudinal Study of ...
(Date:5/27/2015)... 27, 2015 Difass USA, a modern ... U.S. with its first three flagship products, Dormiva™, Relaxiva™ ... nationwide through http://www.difassusa.com . , A restful ... productivity, but some people struggle with getting the full ... a sleep aid designed to help you fall asleep ...
(Date:5/27/2015)... This is a professional and in-depth ... industry. The report provides a basic overview of ... chain structure. The Omega-3 market analysis is provided ... landscape analysis, and key regions development status. Lysi, ... Seadragon Marine Oils, Norwegian Fish Oil, Croda Health ...
(Date:5/27/2015)... 27, 2015 With a prevalently high ... conducted during the "ACA - Controlling the Chaos" webinar ... are currently in the process of researching ACA ... confidently prepared for the reporting mandates. , According to ... webinar, those who are currently vetting ACA reporting solutions ...
Breaking Medicine News(10 mins):Health News:San Marcos Dentistry Office Offering a New Service Dental Case Planning 2Health News:Recent Study About the Link Between Diet Sodas and Abdominal Fat Reinforces Bedford Commons OB-GYN's Recommendation to Drink Plenty of Water 2Health News:Supplement Brand Difass USA Launches in the U.S. with Three Flagship Products Designed to Bring Balance Back to Your Life 2Health News:Omega-3 Market: Global 2015 Analysis & 2020 Forecasts on Market Size 2Health News:Employers are On Track for ACA Reporting According to Businessolver Poll 2
... , Hamilton, ON (Dec. 22, 2011) - McMaster University researchers ... (HRT) is associated with breast cancer globally. This study comes ... this medication to control hot flashes and other symptoms of ... U.S. Women,s Health Initiative (WHI) study of 2002 which found ...
... may have enough harmful noise exposure to risk hearing loss, ... Historically, loud workplaces were blamed for harmful noise levels. ... noise from MP3 players and stereo use has eclipsed loud ... School of Public Health and the Risk Science Center. Robyn ...
... , WEDNESDAY, Dec. 21 (HealthDay News) -- Life expectancy ... with their doctors but very few have that discussion, a ... an average age of 78 who had multiple illnesses and ... San Francisco. None of the patients had been diagnosed with ...
... by Dr. David Spence of The University of Western Ontario ... Health in today,s Journal of the American Medical Association (JAMA) ... in reducing stroke. Vitamin B therapy was ... of this amino acid in the bloodstream was linked to ...
... , WEDNESDAY, Dec. 21 (HealthDay News) -- The holidays ... depression. Experts from Gottlieb Memorial Hospital, part of the ... increase in self-destructive behavior. They noted however, there are ways ... they end up in the emergency room. "For those ...
... chemicals are in use and about 700 new chemicals ... States, according to the U.S. Government Accountability Office. To ... James Englehardt, professor in the College of Engineering at ... that is more efficient than current methods., The new ...
Cached Medicine News:Health News:Do you hear what I hear? Noise exposure surrounds us 2Health News:Most Sick or Disabled Seniors Want Docs to Say How Long They Have 2Health News:Holiday Blues May Signal Depression 2Health News:UM researcher develops new way to assess risk for chemicals 2
(Date:5/27/2015)... , May 27, 2015 ... announced the addition of the  "2015 Strategies ...  report to their offering.  ... five-country report contains 500 pages, 120 tables, ... and potential market entrants identify and evaluate ...
(Date:5/27/2015)... May 27, 2015 Protein purification involves the ... differences in their physical properties. The objective of a ... of functional protein with fewest contaminants. The global protein ... a CAGR of around 5% to 6% during the ... research in the pharmaceutical and biotechnological fields, growing need ...
(Date:5/27/2015)... 27, 2015 Research ... addition of the  "Asia Pacific Ultrasound Devices ... - 2019)"  company profile to their ... , ,Ultrasound is a type of imaging. ... at body parts and structures inside the ...
Breaking Medicine Technology:European Hemostasis Diagnostic Testing Market Strategies 2015 2Protein Purification & Isolation Market by Technology by Product by Application & End User - Global Forecast to 2020 2Protein Purification & Isolation Market by Technology by Product by Application & End User - Global Forecast to 2020 3Asia Pacific Ultrasound Devices Market Report 2015 - Growth, Trends And Forecasts 2014 - 2019 2
... Kaiser Permanente Hawaii has received the inaugural Pharmacy ... Permanente,s achievement of a 5-star rating on the PQA ... Centers for Medicare and Medicaid Services (CMS) Star Rating ... because it uses publicly available quality data from CMS," ...
... June 2, 2011 Mylan Inc. (Nasdaq: ... Inc. has received final approval from the U.S. Food ... Application (ANDA) for Venlafaxine Hydrochloride (HCl) Extended-release (ER) Capsules, ... (base), the generic version of Wyeth,s Effexor XR® Capsules, ...
Cached Medicine Technology:PQA Recognizes Kaiser Permanente Hawaii for Excellence in Medication Safety 2
This handheld reference is a practical guide to established surgical oncology principles for each organ system....
This handy reference contains all of the essential information that surgical residents and medical students need to have at their fingertips for day-to-day patient care....
CURRENT Consult: Surgery brings you authoritative clinical answers on more than 360 surgically treated disorders in the most efficient format, perfectly devised for the busy physician....
Over 10,000 entries. This dictionary is both a home medical guide and as an aid for all those working in the medical and allied professions. The entries are laid out and jargon-free....
Medicine Products: