Navigation Links
Drug makes leukemia more vulnerable to chemo
Date:3/20/2012

Doctors at Washington University School of Medicine in St. Louis have shown that a new drug makes chemotherapy more effective in treating acute myeloid leukemia, a cancer of the white blood cells. Instead of attacking these cells directly, the drug helps drive them out of the bone marrow and into the bloodstream, where they are more vulnerable to chemotherapy.

"We're usually very good at clearing these leukemia cells from the blood," says Geoffrey L. Uy, MD, assistant professor of medicine and co-first author on the study published in the journal Blood. "But it's much harder to clear these cancerous cells from the bone marrow."

This combined phase 1 and 2 clinical trial included 52 patients with acute myeloid leukemia (AML) who had relapsed or whose AML was resistant to the standard chemotherapy regimen. In the phase 2 portion with 46 patients, all received the investigational drug, and 46 percent achieved complete remission, meaning no evidence of cancer could be found in the blood or bone marrow after treatment.

"In general, we see complete remission rates between 20 and 30 percent," says Uy, who treats patients at the Alivn J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. "But a lot depends on individual patient characteristics."

Indeed, recent genetic studies have shown that mutations leading to AML may differ greatly among patients. But regardless of individual mutations, all of these leukemia cells rely in some way on the protective effects of the bone marrow, according to senior author John F. DiPersio, MD, PhD, the Virginia E. and Sam J. Golman Professor of Medicine.

"With DNA sequencing identifying so many mutations that are unique to one patient, it may be very hard to find therapies that work directly on the cancer," says DiPersio, who also treats patients at the Siteman Cancer Center. "Instead, we are targeting a common pathway that all leukemic cells
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Adapting to clogged airways makes common pathogen resist powerful drugs
2. Wedding Band Makes Jealousy a Bigger Threat
3. New Online Store Makes Buying Cosmetics a Healthy Choice
4. AARP Makes Senate Vote on Idaho Health Freedom Act Accountability Vote
5. Parkinsons disease makes it harder to figure out how other people feel
6. Psychosurgery makes gentle comeback
7. Locum Tenens Staffing Firm Makes Inavero's 2010 Best of Staffing List
8. New Gender-Neutral Flex-Friendly Certification Makes the Business Case for Flex Even in a Tough Economy.
9. Zenger Folkman Makes 2010 Top 20 Leadership Training List
10. Healthy food makes consumers feel hungrier when choices are limited
11. IRS Whistleblower Office Makes Good Again: Kenney & McCafferty Whistleblowers Receive Full Reward
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014 Although there are only 24 hours in ... people who have trouble finding time within their busy schedules for ... long periods of time to get in shape. Here are five ... the go. , Change Up Your Commute , Consider riding ... add some exercise into your daily routine. If you must use ...
(Date:10/22/2014)... 2014 Akeso Biomedical, Inc. , ... treatment of bacterial infections, microbial biofilms, and chronic wounds, ... board of directors. , Dr. Sinskey ... The Massachusetts Institute of Technology, or MIT. He has ... Dr. Sinskey also holds positions as Co-Director of the ...
(Date:10/22/2014)... Two sisters in high school have developed ways to ... Krishen use electronic stethoscopes, which electronically amplify body sounds, ... or heartbeats. Ilina, a senior at Port Huron ... way to detect early lung damage in people exposed ... recorded one breath cycle each from 16 smokers, 25 ...
(Date:10/22/2014)... News) -- Measures taken by Firestone officials at the ... have limited the spread of the disease there and ... Natural Rubber Co. provides health services to about 80,000 ... populated communities. Between Aug. 1 and Sept. 23, ... those 80,000 people. That incidence rate of 0.09 percent ...
(Date:10/20/2014)... 20, 2014 The newly updated Worldwide ... of thousands of facts, figures and forecasts on the ... medical sector forecast categories the Worldwide Medical Market ... and national views on the worldwide medical market to ... report gives you data for 2010-2019, covering each country ...
Breaking Medicine News(10 mins):Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4
... provide its comprehensive preventive care web service to STHS members and ... and motivate individuals to improve their health and safety. , ... ... a new partnership with eDoc4u , all eligible members and ...
... First Annual Diversity Council Honors Award(TM)RIDGEFIELD, Conn., ... top honor from the Association of Diversity ... Council Honors Award(TM). The award recognizes the ... diversity council groups that lead diversity processes ...
... Xevo TQ and Synapt HDMS Mass Spectrometers Target ... April 1 Waters Corporation (NYSE: ... Institute,s Center for Cancer Research in Bethesda, Md., ... and Waters ACQUITY(R) UPLC/Xevo(TM) TQ MS Systems for ...
... (AVP) receptor antagonist now available in new premixed ... Pharma US, Inc. today announced the commercial availability ... injection) Premixed in 5% Dextrose, a new premixed ... arginine vasopressin (AVP) receptor antagonist, is the first ...
... Eyecare Professionals Advise Diabetics on How to Minimize That ... Organization reports that 366 million cases of diabetes are ... because of the risk posed to healthy sight by ... Optical, Inc. reveals a dangerous lack of awareness about ...
... a drug took the fun out of stealing, would it ... 1st issue of Biological Psychiatry , published by Elsevier, ... is a type of impulse control disorder characterized by persistent ... an irresistible urge to steal items they often don,t even ...
Cached Medicine News:Health News:Nashville's eDoc4u Signs Partnership Agreement With Saint Thomas Health Services 2Health News:Nashville's eDoc4u Signs Partnership Agreement With Saint Thomas Health Services 3Health News:Boehringer Ingelheim Recognized For Diversity And Inclusion Efforts 2Health News:Waters Corporation Announces the Purchase of UPLC/MS Systems by the National Cancer Institute for Advanced Metabolomics Research 2Health News:Waters Corporation Announces the Purchase of UPLC/MS Systems by the National Cancer Institute for Advanced Metabolomics Research 3Health News:Astellas Launches Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia 2Health News:Astellas Launches Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia 3Health News:Astellas Launches Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia 4Health News:Lack of Awareness of Eye Health Risk Associated with Diabetes Poses Blinding Threat to Millions 2Health News:Lack of Awareness of Eye Health Risk Associated with Diabetes Poses Blinding Threat to Millions 3Health News:Lack of Awareness of Eye Health Risk Associated with Diabetes Poses Blinding Threat to Millions 4Health News:Suppressing the compulsion to steal 2
(Date:10/22/2014)... , Oct. 22, 2014  Charlene Vernak, RPh, of ... , recently was awarded the George Roentsch Scholarship ... received the award in Houston ... scholarship is awarded annually to an independent pharmacist and ... of George Roentsch , a well-known pharmacist in ...
(Date:10/22/2014)... , Oct. 22, 2014 Moms are ... health trackers for themselves and their kids, according to ... Report: Health & Fitness Go Mobile for Moms, the ... Series. BabyCenter, the number 1 pregnancy and parenting web ... that 55 percent of moms surveyed say they can,t ...
(Date:10/22/2014)... SAN DIEGO , Oct. 22, 2014 ... II medical device received 510 (k) OTC clearance by ... the AVACEN 100 to be marketed over the Internet ... with arthritis; muscle spasms; and minor strains and sprains ... The AVACEN 100 (MSRP $2495) is a ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
...  Leading events organiser UBM Live has revealed further ... Pharma Portfolio, CPhI Southeast Asia (SEA) 2012. Set to debut ... Indonesia, CPhI SEA is the first trade show and exhibition ... sector in the ASEAN region. CPhI SEA ...
... Conn., April 18, 2012   A new retrospective ... rates of intracranial hemorrhage (ICH), including both fatal and ... taken twice daily compared with warfarin. Results of the ... Journal of the American Heart Association. ...
Cached Medicine Technology:Leading Pharma Ingredients Event Debuts in Growing ASEAN Market 2Leading Pharma Ingredients Event Debuts in Growing ASEAN Market 3New Sub-Analysis Evaluates Outcomes Associated with Lower Intracranial Hemorrhage Rates for Pradaxa® (dabigatran etexilate mesylate) Versus Warfarin in the RE-LY® Trial 2New Sub-Analysis Evaluates Outcomes Associated with Lower Intracranial Hemorrhage Rates for Pradaxa® (dabigatran etexilate mesylate) Versus Warfarin in the RE-LY® Trial 3New Sub-Analysis Evaluates Outcomes Associated with Lower Intracranial Hemorrhage Rates for Pradaxa® (dabigatran etexilate mesylate) Versus Warfarin in the RE-LY® Trial 4New Sub-Analysis Evaluates Outcomes Associated with Lower Intracranial Hemorrhage Rates for Pradaxa® (dabigatran etexilate mesylate) Versus Warfarin in the RE-LY® Trial 5New Sub-Analysis Evaluates Outcomes Associated with Lower Intracranial Hemorrhage Rates for Pradaxa® (dabigatran etexilate mesylate) Versus Warfarin in the RE-LY® Trial 6New Sub-Analysis Evaluates Outcomes Associated with Lower Intracranial Hemorrhage Rates for Pradaxa® (dabigatran etexilate mesylate) Versus Warfarin in the RE-LY® Trial 7
Carl Zeiss immersion oils are PCF free. They are quality controlled for two wavelengths of light, Ne=1.518 and Nd=1.515 at 23ºC....
Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
... Oils are the standard - the ones to ... Laboratories has consistently led in the development and ... Here is the record: , When the FDA ... of In Vitro Diagnostics in the 1970's, Cargille ...
... an Informatics software product enabling quick and ... the laboratory. With SpecTRACK Software, users can ... specimen from all laboratories in their LAN ... or cold room. Automate your existing manual ...
Medicine Products: