Navigation Links
Drug kills cancer cells by restoring faulty tumor suppressor
Date:5/14/2012

A new study describes a compound that selectively kills cancer cells by restoring the structure and function of one of the most commonly mutated proteins in human cancer, the "tumor suppressor" p53. The research, published by Cell Press in the May 15th issue of the journal Cancer Cell, uses a novel, computer based strategy to identify potential anti-cancer drugs, including one that targets the third most common p53 mutation in human cancer, p53-R175H. The number of new cancer patients harboring this mutation in the United States who would potentially benefit from this drug is estimated to be 30,000 annually.

P53 recognizes cellular stress and either puts the brakes on cell proliferation, or kills the cell if the damage is irreparable. The gene encoding p53 is mutated in over half of human cancers, and loss of p53 function has been linked to many aspects of cancer including aggressiveness, metastasis and poor response to chemotherapy and radiation. "Restoring the function of mutant p53 with a drug has long been recognized as an attractive cancer therapeutic strategy," explains senior study author, Dr. Darren R. Carpizo, from The Cancer Institute of New Jersey. "However, it has proven difficult to find compounds that restore the lost function of a defective tumor-suppressor."

Dr. Alexei Vazquez, a co-author of the study, developed a computer based screening method to identify compounds that target tumor cells with p53 mutations, but not cells with normal p53. The screening method was unique because it involved cancer cells with diverse genetic backgrounds, a model that recapitulates what is seen in actual human cancers. This method identified several compounds that killed cancer cells containing mutant p53. One of the compounds did so by restoring the structure and function of the p53-R175H mutant. The researchers went on describe the details of the reactivation mechanism and showed that normal cells were not impacted by the compound.

In addition to identifying a compound for selectively restoring the function of the p53-R175H mutant, the findings also support the development of rationally targeted cancer therapies. "Anti-cancer drug development is moving in the direction of "personalized medicine" in which the drugs are chosen based on the molecular pathways that are deranged in an individual patient's tumor," concludes Dr. Carpizo. "Our findings support the growing trend in developmental therapeutics in which the efficacy of future cancer drugs will depend upon the knowledge of the patient's tumor genotype."


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
2. More Evidence Bilingualism Aids Thinking Skills
3. Parents poor math skills may lead to medication errors
4. Physicians mindfulness skills can improve care for patient and provider
5. Study determines critical skills for PCPs to safely manage opioid risk in chronic pain patients
6. Poor Reading Skills Might Be Fatal for Older Folks
7. New compound discovered that rapidly kills liver cancer
8. Hepatitis C Now Kills More Americans Than HIV
9. Blocking telomerase kills cancer cells but provokes resistance, progression
10. Autism affects motor skills, study indicates
11. A leukemia drug kills cancerous T-cells while sparing normal immunity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... to revolutionize the emergency ambulance transport experience for the millions of people who ... Uber has disrupted the taxi industry through the use of technology. Now, SmartEMS ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
Breaking Medicine Technology: