Navigation Links
Drug inhibits neuroblastoma blood supply in pre-clinical tests
Date:4/24/2009

SAN DIEGO - Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found a way to prevent blood vessels from aiding the growth of neuroblastoma, a childhood cancer. The pre-clinical study was presented today in a platform session at the 22nd annual meeting of the American Society of Pediatric Hematology/Oncology.

Investigators at the Children's Cancer Hospital at M. D. Anderson have discovered that the drug, AMD3100, hinders the formation of tumor blood vessels and reduces human neuroblastoma tumor growth by more than 75 percent in mice.

The drug blocks interaction between SDF-1a and its receptor CXCR4. This pathway plays an important role in signaling cells to different areas of the body. More specifically, the study suggests that SDF-1a plays a role in differentiating and/or attracting pericyte-like cells to neuroblastoma tumors.

Pericytes are essential for organizing blood vessels to feed tumors. Without pericytes, blood vessels are dysfunctional and tumors are left without a vital blood source. This study found that AMD3100 decreased the number of pericyte-like cells in neuroblastoma tumors by close to 90 percent.

"AMD3100 works by shutting down the process that tumors need to set up vascular systems," says Patrick Zweidler-McKay, M.D., Ph.D., assistant professor at the Children's Cancer Hospital and senior investigator on the study. "The drug doesn't kill neuroblastoma cells directly, but it prevents tumors from growing rapidly by disrupting their blood supply."

In tissue culture, investigators were also able to show how AMD3100 prevented neuroblastoma cells from migrating toward SDF-1a ligands. SDF-1a is present at high levels in the bone marrow, one of two areas where neuroblastoma most commonly metastasizes.

"There is the possibility that this therapy could help prevent neuroblastoma metastasis to the bone marrow. However, more studies are
'/>"/>

Contact: Lindsay Anderson
lindsay.anderson@gabbe.com
212-220-4444
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Helicobacter pylori inhibits intercellular communication of cultured gastric cells
2. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
3. Embryonic Stem Cell Protein Inhibits Melanoma
4. Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
5. Ingredient found in green tea significantly inhibits breast cancer growth in female mice
6. Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
7. Calorie restriction inhibits, obesity fuels development of epithelial cancers
8. Grapefruit Compound Inhibits Hepatitis C Virus
9. Herpes drug inhibits HIV replication, but with a price
10. Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
11. Drug Inhibits Colon Cancer in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug inhibits neuroblastoma blood supply in pre-clinical tests
(Date:3/2/2015)... 2015 Representatives with BNatrl ( ... launched a multivitamin supplement that’s specifically designed for ... for BNatrl, said the multivitamin, which launched Jan. ... other world-class athletes. , "Being an avid marathon ... whole food multivitamin to improve my performance,” said ...
(Date:3/2/2015)... Atlantic Information Services, Inc. (AIS) is pleased to ... Plans: 2015 , the all-new 12th edition of the ... market, with enrollment data and contact information for health ... as a printed book containing the full directory and ... and charts, as well as an electronic version, AIS’s ...
(Date:3/2/2015)... TX (PRWEB) March 02, 2015 What ... How should physicians request references? When are interviews scheduled, ... analyze employment opportunities?, Both training and practicing physicians who ... to these questions and more at the PracticeLink Physician ... 18. The drop-in Job Fair is from 5:30 to ...
(Date:3/2/2015)... Final Cut Pro X plugin specialists have ... Film Studios. , “The TranStatic Volume 2 plugin gives users ... CEO of Pixel Film Studios. “TranStatic Volume 2 is a ... editors toolbox.” , With TranStatic Volume 2 users can transition ... scrambling effects from Pixel Film Studios. Users have total control ...
(Date:3/1/2015)... Excellence is pleased to announce the addition of a digital ... are over 75 terms and phrases available for viewing, with more ... patients a better understanding of what our Providers are talking about ... With this resource, our patients are able to go back to ... that they may not remember or comprehend at the time of ...
Breaking Medicine News(10 mins):Health News:Bnatrl Launches Multivitamin Supplement for Runners 2Health News:Now Available from AIS: 12th Edition of Annual Book Containing Health Plan Enrollment Data, Contact Information 2Health News:PracticeLink to Host a Career Advancement Workshop and Job Fair in Houston 2Health News:Pixel Film Studios released the TranStatic Volume 2 plugin for Final Cut Pro X today 2
... of brain tumor , , MONDAY, June 2 (HealthDay News) -- ... malignant brain tumor that was diagnosed last month. , The ... an especially lethal type of brain tumor, at Duke University ... Massachusetts Democrat,s office said he would be operated on by ...
... in 81 years the International Congress of Genetics takes place ... Nobel Prize winners get together with more than 2000 scientists ... genome analysis. The congress, which takes place for the 20th ... also being Berlin. Congress Chairman is Prof. Rudi Balling, Scientific ...
... PETERSBURG, Fla., June 2 The Advanced,Wound Management Division ... that its negative pressure wound therapy (NPWT) products will ... included in the,first phase of the competitive bidding program ... in the U.S. The program, which is,scheduled to take ...
... completed ... phase I studies, SAN ... of a worldwide exclusive agreement entered into in Feb,2008, GlaxoSmithKline (GSK) ... original agreement, GSK has rights to develop,manufacture and commercialize FLAP (5-Lipoxygenase ...
... Imagine being able to communicate,your practice,s message to ... practice growth and development. That is the focus of ... parent company of JG Pads, a pharmaceutical sales,support company ... United States since 1993. Because of its success, MarketHATCH ...
... Scientists at the University of Liverpool have found that ... antibiotics, suggesting that the infection is unlike the bacteria ... resistant to antibiotics and can sometimes go undetected in ... spread to humans. The team tested the strains found ...
Cached Medicine News:Health News:Sen. Kennedy Undergoing Surgery for Brain Tumor 2Health News:Sen. Kennedy Undergoing Surgery for Brain Tumor 3Health News:Sen. Kennedy Undergoing Surgery for Brain Tumor 4Health News:6 Nobel Prize Winners at International Congress of Genetics 2Health News:6 Nobel Prize Winners at International Congress of Genetics 3Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 2Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 3Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 4Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 5Health News:Amira Pharmaceuticals Achieves Milestones in FLAP Inhibitor Program With GlaxoSmithKline 2Health News:Ohio Company to Debut Turnkey Marketing Material During Florida National Dental Convention 2Health News:Salmonella in garden birds responsive to antibiotics 2
(Date:3/2/2015)... , March 2, 2015 Isis Pharmaceuticals, Inc. (NASDAQ: ... a $15 million milestone payment from GSK related to advancing ... with familial amyloid polyneuropathy (FAP).  "We are ... Rx , and plan to report data from the Phase ... the fifteen months of dosing and are now receiving ISIS-TTR ...
(Date:3/2/2015)... N.J. and BETHESDA, Md. ... development-stage immunotherapy company focused on treating and preventing autoimmune ... 2-stage, anti-IL-15 monoclonal antibody (AMG 714) from Amgen (NASDAQ: ... exclusive license agreement, Celimmune has the rights to develop, ... excluding Japan . Concurrently, Amgen has ...
(Date:3/2/2015)... Texas , March 2, 2015   Lexicon ... biopharmaceutical company focused on developing breakthrough treatments for human ... 2014 financial results on Wednesday, March 4, 2015 before ... conference call and webcast to discuss clinical development progress ... end of 2014 at 10:00 a.m. Eastern Time on ...
Breaking Medicine Technology:Isis Pharmaceuticals Earns $15 Million From GSK for Advancing ISIS-TTR Rx 2Isis Pharmaceuticals Earns $15 Million From GSK for Advancing ISIS-TTR Rx 3Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 2Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 3Lexicon To Report Fourth Quarter And Year End 2014 Financial Results On March 4, 2015 2
... Inc. (Nasdaq: STXS ) announced today that the underwriters ... have exercised in full their over-allotment option to purchase an ... 7,475,000 shares of Stereotaxis common stock in the offering, including ... sold at a price to the public of $4.00 per ...
... 12 Leaders of the medical technology industry ... E. Washington Convention Center for the third annual ... mix of medical technology executives, innovators, policymakers, media, ... and 32 states, are expected to attend this ...
Cached Medicine Technology:Stereotaxis Announces Underwriters' Exercise of Over-Allotment Option 2Stereotaxis Announces Underwriters' Exercise of Over-Allotment Option 3Medical Technology Executives Descend on D.C. as AdvaMed 2009: The MedTech Conference Kicks Off and Health Care Debate Continues 2Medical Technology Executives Descend on D.C. as AdvaMed 2009: The MedTech Conference Kicks Off and Health Care Debate Continues 3
Take Performance to a Higher Level....
The MULTI-LINK PIXEL Coronary Stent System was designed to address the challenges of small vessel treatment in patients with abrupt or threatened abrupt closure (ATC)....
FemoStop plus system is a femoral compression system for hemostasis management. It provides a comfortable and efficient "hands off method of compressing the femoral artery and vein after diagnostic ...
... used to seal the arterial puncture site. Duett ... the arteriotomy and the tissue tract with a ... a balloon catheter and procoagulant - the Duett ... stop the bleeding. The Duett is unique in ...
Medicine Products: