Navigation Links
Drug holds promise to halt debilitating condition of diabetes
Date:9/10/2010

LAWRENCE A drug developed at the University of Kansas has the potential to stop a debilitating condition of diabetes that often leads to pain in the extremities and even amputations, KU researchers have found.

The researchers recently published an article showing that KU-32 can stop and even reverse diabetic peripheral neuropathy, or DPN, in mice. The condition leads to death of nerves in the extremities of individuals with diabetes.

"People with DPN can be very sensitive to light touch, which can cause significant pain," said Rick Dobrowsky, professor of pharmacology and toxicology and one of the paper's authors. "The other side is eventually diabetes causes death of the nerves. DPN often leads to loss of feeling in the hands and feet, which can make diabetics susceptible to wounds and infections and often leads to amputations of toes and feet."

DPN is the second leading cause of amputations, after injuries.

Dobrowsky co-authored the paper with Brian Blagg, professor of medicinal chemistry; Roger Rajewski, professor of pharmaceutical chemistry; Joanna Krise and Michelle McIntosh, research associates with the Biotechnology Innovation and Optimization Center; Cuijuan Yu, research associate with the Higuchi Biosciences Center; postdoctoral researcher Yuanming Lu; and graduate students Michael Urban and Cuijuan Yu. It was published in the American Society of Neurochemistry's journal, ASN Neuro.

The researchers administered KU-32 to diabetic mice. The compound stopped DPN and showed it could restore sensory neuron function to damaged nerve tissue. KU-32 inhibits a specific member of a family of proteins called molecular chaperones.

"These studies provide the first evidence that targeting molecular chaperones reverses the sensory hypoalgesia associated with DPN," the authors wrote.

There are approximately 24 million diabetics in the United States. Dobrowsky said nearly 60 percent of them suffer from DPN at some point. The researchers hope that eventually the drug could be used to help to treat the condition in humans. Their research shows KU-32 can be administered orally as infrequently as once a week and still be effective. It has been shown to have long-term efficacy, meaning it could be administered in small doses, potentially reducing severity of side effects.

"Our tests so far indicate that KU-32 is completely nontoxic and is absorbed in the blood stream very well," said Blagg. "It has long-term efficacy. It is a promising treatment."

There are only two FDA-approved drugs used for treatment of DPN, Blagg said. However, one is an anticonvulsant and the other is an antidepressant, and neither has the potential to reverse nerve degeneration.

The research, funded by grants from the Juvenile Diabetes Research Foundation and the National Institutes of Health, is ongoing. The team is hoping to discover how long the drug can be effective in combating DPN. People often find out they have diabetes when they are suffering from the nerve-degenerating condition.

"The idea is to try to determine at what point in nerve degeneration will be most effective and at what point the drug will not be efficacious," Dobrowsky said. "We'd like to know at what stage in the progression of DPN a window of opportunity exists for the beneficial use of KU-32."

The researchers also hope to determine exactly how the drug stopped and reversed DPN in mice. It's not immediately evident if it improved existing nerve fibers or generated new ones.

The drug is still in pre-clinical development. It will likely need another year or two of study, then the researchers hope it could be advanced to clinical trials in humans.

Dobrowsky said the collaboration of researchers with different areas of expertise was key to the study.

"This is an excellent example of how collaboration allows us to achieve one of the School of Pharmacy's goals, to discover medications that enhance and extend life," he said.


'/>"/>

Contact: Mike Krings
mkrings@ku.edu
785-864-8860
University of Kansas
Source:Eurekalert

Related medicine news :

1. Old drug holds promise against opportunistic lung bug
2. AthletiCo Physical Therapy Holds July Cell Phone Drive
3. Chinese Biopharmaceutical Association Successfully Holds 15th Annual Conference
4. U.S. Panel Upholds Ban on Gay Men as Blood Donors
5. SISEL International Holds Successful Launch Events In Ukraine
6. Baden Elementary School holds VisionWalk to Fight Blindness
7. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
8. Construction Accident Lawyer Says Recent News Of Mine Disaster Holds Lessons For Construction Safety
9. ATSU –ASHS Holds Spring Commencement Ceremony
10. Morehead Associates, Inc. Holds Annual Peer to Peer Conference(TM)
11. Gene Holds Key to Embryonic Stem Cell Rejuvenation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... 23, 2017 , ... DMG Productions is proud to announce ... scheduled to broadcast Saturday, January 28, 2017 at 5:00pmEST. , This segment will ... address the limitations of fatigue monitoring technologies within the mining industry. Today SmartCap ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... organization in North America for the scientific development, healthcare training and clinical application ... Session, and its 2017 AAT Member Certification Qualification Courses for Technicians, respectively. , ...
(Date:1/23/2017)... ... January 23, 2017 , ... "ProRandom is a set of camera tools that allow video editors ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... text with video footage. ProRandom works by using a virtual camera to create the ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Crossing the Bar”: a moving and eloquent ... life. “Crossing the Bar” is the creation of published author, Charlotte Hotte, a North ... who credits the inspiration of the book to her sister, Denise, wishes to acknowledge ...
(Date:1/22/2017)... ... , ... Phytocéane invites clients to take an exotic journey deep into the ... MILKY CREAM. Inspired by the beauty of Zanzibar, a Tanzanian archipelago off the coast ... coral to create this gentle, velvety body cream to envelop the skin in moisture ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... InDex Pharmaceuticals Holding AB (publ) today announced ... of the European Crohn,s and Colitis Organisation (ECCO). The ECCO congress ... on inflammatory bowel disease (IBD). The congress is held in ... ... again having been selected to present data at the largest IBD ...
(Date:1/21/2017)... , Jan. 20, 2017 ResMed (NYSE: ... Medical ( Winter Haven, Florida ) today announced they ... parties. BMC and 3B will be permitted to sell their existing ... make a one-time settlement payment to 3B to close the ... did not include an admission of liability or wrongdoing by any ...
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... Trends - Technology, Route Of Administration, End User - Forecast to ... ... to grow at a CAGR of around 7.8% over the next ... This industry report analyzes the global markets for Advanced Drug Delivery ...
Breaking Medicine Technology: