Navigation Links
Drug holds promise to halt debilitating condition of diabetes
Date:9/10/2010

LAWRENCE A drug developed at the University of Kansas has the potential to stop a debilitating condition of diabetes that often leads to pain in the extremities and even amputations, KU researchers have found.

The researchers recently published an article showing that KU-32 can stop and even reverse diabetic peripheral neuropathy, or DPN, in mice. The condition leads to death of nerves in the extremities of individuals with diabetes.

"People with DPN can be very sensitive to light touch, which can cause significant pain," said Rick Dobrowsky, professor of pharmacology and toxicology and one of the paper's authors. "The other side is eventually diabetes causes death of the nerves. DPN often leads to loss of feeling in the hands and feet, which can make diabetics susceptible to wounds and infections and often leads to amputations of toes and feet."

DPN is the second leading cause of amputations, after injuries.

Dobrowsky co-authored the paper with Brian Blagg, professor of medicinal chemistry; Roger Rajewski, professor of pharmaceutical chemistry; Joanna Krise and Michelle McIntosh, research associates with the Biotechnology Innovation and Optimization Center; Cuijuan Yu, research associate with the Higuchi Biosciences Center; postdoctoral researcher Yuanming Lu; and graduate students Michael Urban and Cuijuan Yu. It was published in the American Society of Neurochemistry's journal, ASN Neuro.

The researchers administered KU-32 to diabetic mice. The compound stopped DPN and showed it could restore sensory neuron function to damaged nerve tissue. KU-32 inhibits a specific member of a family of proteins called molecular chaperones.

"These studies provide the first evidence that targeting molecular chaperones reverses the sensory hypoalgesia associated with DPN," the authors wrote.

There are approximately 24 million diabetics in the United States. Dobrowsky said nearly 60 percent of them suffer f
'/>"/>

Contact: Mike Krings
mkrings@ku.edu
785-864-8860
University of Kansas
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Old drug holds promise against opportunistic lung bug
2. AthletiCo Physical Therapy Holds July Cell Phone Drive
3. Chinese Biopharmaceutical Association Successfully Holds 15th Annual Conference
4. U.S. Panel Upholds Ban on Gay Men as Blood Donors
5. SISEL International Holds Successful Launch Events In Ukraine
6. Baden Elementary School holds VisionWalk to Fight Blindness
7. ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth
8. Construction Accident Lawyer Says Recent News Of Mine Disaster Holds Lessons For Construction Safety
9. ATSU –ASHS Holds Spring Commencement Ceremony
10. Morehead Associates, Inc. Holds Annual Peer to Peer Conference(TM)
11. Gene Holds Key to Embryonic Stem Cell Rejuvenation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... Anthropologists have identified concrete recommendations that ... Ebola, improve international support, and pave the way ... Africa. , The report, “Strengthening West African ... Insights,” will be made public during a press ... Fri., Dec. 5, 11 a.m., at the AAA ...
(Date:11/26/2014)... Angeles, California (PRWEB) November 26, 2014 ... score of 3.9 out of 5. This score represents ... over the three years to 2014 as a result ... for medical suction machines, which are largely considered nondiscretionary. ... the purchasing process, buyers have some degree of flexibility, ...
(Date:11/26/2014)... 2014 For those with a New Year’s ... MILLS BODYPUMP™ classes at the University of Colorado Anschutz ... been looking for. The 45- 60 minute classes have just ... Wellness Center fitness club memberships. , LES MILLS BODYPUMP™ exercise ... and are aimed at fast results , By focusing ...
(Date:11/26/2014)... 2014 News Facts , Lexmark’s ... at RSNA 2014 in Chicago. The company will ... diagnostic images, photos, videos and documents found throughout ... will learn more about these innovative medical content ... partner initiatives – that enable more informed clinical ...
(Date:11/26/2014)... of the most important and vital decisions a woman ... choosing the ideal wedding dress and bridesmaid dresses. BellasDress.com ... quality outfits. Today, BellasDress.com has unveiled its new range ... suitable bridesmaid gowns here at discount prices. , Formal ... and highlight all their most beautiful features while drawing ...
Breaking Medicine News(10 mins):Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 2Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 3Health News:Medical Suction & Vacuum Products Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Medical Suction & Vacuum Products Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Medical Suction & Vacuum Products Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:LES MILLS BODYPUMP™ classes come to the University of Colorado Anschutz Health and Wellness Center 2Health News:Perceptive Software to Demonstrate New Medical Content Management Features and Capabilities at RSNA 2014 2Health News:Perceptive Software to Demonstrate New Medical Content Management Features and Capabilities at RSNA 2014 3Health News:Royal Blue Bridesmaid Dresses Now Are Available for Christmas at BellasDress.com 2
... Jesse Salen, the VP of Sales and Technology at Online Radiology ... are available, including remote reading of echo-cardiogram ultrasounds and functional MRI ... ... November 14, 2008 -- RSNA 2008 Booth 3661 -- Jesse Salen, ...
... a metabolism booster, weight reducer and athletic enhancer, sales of acai products ... harvested in the Brazilian rainforest from acai palms that may reach heights ... to harvest edible hearts of palm. , ... Green Bay, WI (PRWEB) ...
... the four social environments in which young people livefamilies, ... whether teens misuse alcohol, with risk from one area ... , That,s the finding of a new longitudinal study ... at Chapel Hill, the University of California at Davis, ...
... other diagnostic measures, British researchers report , , THURSDAY, Nov. ... the standard test for measuring the activity of the ... coronary problems for people who are examined because of ... with stable chest pain, suspected angina, the resting EKG ...
... Va., Nov. 13, 2008 James G.,Carlson, Chairman and CEO ... America,s "Premature Birth Report Card," which was,released November 12 by ... deserves a fair chance to grow up in good,health. But ... its ,Premature,Birth Report Card, that is not the case today. ...
... Nov. 13 There are more than 70,million Americans ... States. As part,of Kmart,s effort to provide helpful information ... Day on November 18th from 9am-1pm,at all 1100 Kmart ... include free blood pressure,screenings, free memory screenings, Medicare health ...
Cached Medicine News:Health News:New Teleradiology Reading Services Are Available at Online Radiology Medical Group, Inc. 2Health News:New Teleradiology Reading Services Are Available at Online Radiology Medical Group, Inc. 3Health News:Research Finds The Brazilian Acai Absorbs Much Better Than Any Other Fruit 2Health News:Families, friends, schools and neighborhoods contribute to adolescent alcohol misuse 2Health News:EKG Not Strong Predictor of Heart Risk 2Health News:EKG Not Strong Predictor of Heart Risk 3Health News:AMERIGROUP Chairman and CEO Urges Action to Improve Nation's 'Premature Birth Report Card' 2Health News:Kmart Pharmacy Celebrates GoldK Day for Seniors 2
(Date:11/26/2014)... Mass. , Nov. 25, 2014 Reinforcing ... Royal Philips (NYSE: PHG AEX: ... and Drug Administration (FDA) for its IQon Spectral ... imaging. This first-of-its kind technology adds a new dimension ... offering the ability to characterize structures based on their ...
(Date:11/26/2014)... EMERYVILLE, Calif. , Nov. 25, 2014 ... nanotechnology company focused on the development of ... more accurate testing in hospital and pre-hospital ... Standards Organization (ISO) 13485:2003 certification.  The certification ... (BSI), one of the world,s leading certification ...
(Date:11/26/2014)... 2014  Unilife Corporation (NASDAQ: UNIS, ASX: UNS), a ... today announced that its Chairman and CEO, Alan ... Jaffray 26th Annual Healthcare Conference at the New York ... 2, 2014. The conference presentation will ... only Webcast. To listen, please go to: http://ir.unilife.com/events.cfm ...
Breaking Medicine Technology:Philips receives FDA 510(k) clearance for IQon Spectral CT 2Philips receives FDA 510(k) clearance for IQon Spectral CT 3Nanomix Receives ISO 13485:2003 Certification 2Unilife to Present at the Piper Jaffray 26th Annual Healthcare Conference on December 2nd 2
... Statement and National HIV/AIDS Elimination Act, NEW YORK, ... role of,advancing prophetic social justice ministry, Black clergy are ... for theologically,sound HIV/AIDS public policy. Working with the National ... live up to the biblical,mandate that calls us to ...
... HEIGHTS, Ill., Oct. 10 Face,transplants, once on ... because of new estimates that suggest the risk ... according to a recent,review in Plastic and Reconstructive ... Society of Plastic Surgeons (ASPS)., "We can ...
Cached Medicine Technology:Statement From The National Conclave on HIV/AIDS Policy for Black Clergy 2Statement From The National Conclave on HIV/AIDS Policy for Black Clergy 3Risks Associated With Face Transplants May Be Lower Than Previously Thought, ASPS Journal Review Suggests 2
10-mm (0.4-in) diameter cups have multi-color lead wires and 2-mm (0.08-in) holes for easy paste/collodion application. Available in a variety of lengths to suit many different needs....
... head cap systems are packaged to provide ... Electro-Cap System features pure tin electrodes positioned ... you place your order, please specify which ... cap system and whether you want regular ...
... takes you into the OR, ER, or ICU, ... Cadwells new shielded electrodes. Keeping noise low and ... disc electrode has a special shielded cable that ... effects of 60-cycle interference. That means you get ...
... incorporates the principle of indirect ophthalmoscopy in the ... to 130 degrees of non-contact fundus observation. ... rotated freely so that the extreme periphery can ... pupils is possible. The SDI erects the ...
Medicine Products: