Navigation Links
Drug helps women who stop smoking keep weight off
Date:12/10/2012

A medication being tested to help smokers kick the habit also may help avoid the weight gain that is common after quitting but only in women, according to a study published in the December issue of Biological Psychiatry. This is the first medication shown to reduce weight gain for up to one year in women smokers who quit.

Naltrexone an opioid blocker that can dampen the desire for alcohol, heroin and nicotine, as well as the pleasures of eating helped men quit smoking. It improved their quit rates after three months of treatment in a large controlled trial, from 17 percent for those who did not get the drug up to 30 percent for those who did.

The drug did not improve quit rates for women beyond that of the placebo. But for the women who successfully quit smoking, their weight gain was reduced by more than half. After three months, those who took naltrexone gained an average of 2.3 pounds while those who took a placebo gained 5.1 pounds.

"When trying to stop smoking, women tend to gain more weight than men and to be more concerned about gaining that weight," said study author Andrea King, PhD, professor of psychiatry and behavioral neuroscience at the University of Chicago Medicine. "Women who try to quit may be so worried about putting on weight in the process that they soon give up, and this is less commonly found in men. Adding naltrexone to standard treatment might help women get through that difficult early period."

While tobacco use is the leading cause of preventable death in the United States, obesity is the second leading cause. Ironically, more than 80 percent of those who are able to stop smoking put on at least five pounds in the year after quitting. Up to 25 percent of those who quit gain more than 15 pounds.

For this study, researchers combined data from the two largest trials using naltrexone to help volunteers stop smoking. The trial included 700 participants, 315 from the University of Chicago and 385 from Yale University. For six to 12 weeks after their quit date, participants took either naltrexone or a placebo. They also used a nicotine patch and attended smoking-cessation counseling for the first month.

After six months, 159 of the 700 participants (23 percent), including 77 women, remained verifiably smoke-free. After 12 months, that number fell to 115 (16 percent), including 57 women.

Over the first 12 months after quitting, weight gain continued to increase for successful quitters, but the benefits of the early treatment with naltrexone persisted. The effect was diminished, however. From a 50-percent reduction in weight gain for those taking the drug when measured at three months, the difference decreased to 40 percent (7.3 vs. 12.1 pounds) at six months, and to 20 percent (13 vs. 16.3 pounds) at 12 months.

"Naltrexone has produced the most promising results to date for helping women who quit smoking gain less weight," King said. "It is possible that the opioid blocker reduces women's tendency to eat high fat and sweet foods when they quit smoking."

But the available tools to help people stop smoking "are not satisfactory," King added. Smoking remains "a huge health problem and most adults in the United States are either overweight or obese. Our study demonstrates that naltrexone may be a promising medication to treat tobacco dependence and unlike the other approved medications, appears to help reduce weight gain for many."


'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert

Related medicine news :

1. Dr. Michael Reiss of Southern Nevada Chiropractic Helps Car Accident Patients with Neck or Back Pain by Providing Computerized Spinal Exam and a Copy of His Book
2. Blueline Products Introduces Lean 6x Fat Burning Formula that Helps Lose 3-6% Fat in 14 Days
3. GiveForward.com Helps Launch Online Campaign to Help Sick Single Mom in Need
4. The Prospero Foundation Helps Provide Safe Drinking Water in Bolivia
5. Omega3 Innovations Helps Local Food Bank Provide Thanksgiving Dinners for those in Need
6. Amyloid imaging helps in evaluating possible Alzheimer disease
7. Gastric bypass surgery helps diabetes but doesnt cure it
8. New method helps target Parkinsons disease
9. Seattle Childrens Research Institute helps identify causes of sagittal craniosynostosis
10. Cant stop? Smoking less helps
11. Gene Distinguishes Early Birds from Night Owls and Helps Predict Time of Death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... Francisco, CA (PRWEB) , ... ... ... intensive lectures and hands-on exercises, the Wharton Seminars for Business Journalists ... a better understanding of key business and economic issues.  This one-day program ...
(Date:5/5/2016)... ... May 05, 2016 , ... Every ... the most heartfelt wishes of these children. The wishes provide hope and ... President and CEO of Make-A-Wish Mississippi, Brent Wilson said, “In 2016, the organization ...
(Date:5/5/2016)... ... ... A recent survey by the Midwest Business Group on Health ... use the free preventive care benefits available to them as part of the Affordable ... public and private employers, MBGH found that only 10% of large employers are aware ...
(Date:5/5/2016)... , ... May 05, 2016 , ... ... Pittsburgh-area schoolchildren has found that more than 40 percent of participating fifth-grade students ... , Director of Allergy and Asthma Clinical Research in the Division of Pulmonary, ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... presented a talk highlighting the organization’s successful Care Transitions program at ... The talk was titled “Minimizing Costs in the Post-Acute Environment Through Effective Transitions ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... COLOGNE, Germany , May 3, 2016  Axiogenesis has acquired a major investment from Sino-German High-Tech Fund to ... http://photos.prnewswire.com/prnh/20160503/362920    Photo - http://photos.prnewswire.com/prnh/20160503/362921 ... ... ... ...
(Date:5/3/2016)... ACME Markets, Delaware County ... County Councilman Dave White announced today the ... ACME pharmacies across Delaware County . ... naloxone has saved 26,463 lives nationwide over the past 20 years. ... were authorized to administer naloxone to overdose victims, 244 ...
(Date:5/3/2016)...  While you may be familiar with watching a film or TV show in high definition, ... 8MP in the Medical Industry.  Ampronix  is a renowned authorized reseller of the medical industry,s ... - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: