Navigation Links
Drug from Mediterranean weed kills tumor cells in mice
Date:7/9/2012

Scientists at the Johns Hopkins Kimmel Cancer Center, working with Danish researchers, have developed a novel anticancer drug designed to travel -- undetected by normal cells -- through the bloodstream until activated by specific cancer proteins. The drug, made from a weedlike plant, has been shown to destroy cancers and their direct blood supplies, acting like a "molecular grenade," and sparing healthy blood vessels and tissues.

In laboratory studies, researchers said they found that a three-day course of the drug, called G202, reduced the size of human prostate tumors grown in mice by an average of 50 percent within 30 days. In a direct comparison, G202 outperformed the chemotherapy drug docetaxel, reducing seven of nine human prostate tumors in mice by more than 50 percent in 21 days. Docetaxel reduced one of eight human prostate tumors in mice by more than 50 percent in the same time period.

In a report June 27 in the journal Science Translational Medicine, the researchers also reported that G202 produced at least 50 percent regression in models of human breast cancer, kidney cancer and bladder cancer.

Based on these results, Johns Hopkins physicians have performed a phase I clinical trial to assess safety of the drug and have thus far treated 29 patients with advanced cancer. In addition to Johns Hopkins, the University of Wisconsin and the University of Texas-San Antonio are participating in the trial. A phase II trial to test the drug in patients with prostate cancer and liver cancer is planned.

The drug G202 is chemically derived from a weed called Thapsia garganica that grows naturally in the Mediterranean region. The plant makes a product, dubbed thapsigargin, that since the time of ancient Greece has been known to be toxic to animals. In Arab caravans, the plant was known as the "death carrot" because it would kill camels if they ate it, the researchers noted.

"Our goal was to try to re-engineer
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Mediterranean diet is definitively linked to quality of life
2. Glucose deprivation activates feedback loop that kills cancer cells, UCLA study shows
3. Sleep apnea persisting into teens can impact life skills, study finds
4. Drug kills cancer cells by restoring faulty tumor suppressor
5. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
6. More Evidence Bilingualism Aids Thinking Skills
7. Parents poor math skills may lead to medication errors
8. Physicians mindfulness skills can improve care for patient and provider
9. Pediatric tumors traced to stem cells in developing brain​​
10. Skin contact breast tumor detection
11. Specialized MRI scans assess value of anti-cancer chemotherapy long before tumors shown to shrink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... ATLANTA July 14, 2014 Physical fitness may buffer ... sitting, according to a new study by researchers from ... University of Texas. The study appears in the journal ... between prolonged sedentary time and obesity and blood markers ... taking fitness into account. , Sedentary behavior has been ...
(Date:7/14/2014)... Wisconsin (PRWEB) July 14, 2014 Secure ... software security, is partnering with the Software Assurance Marketplace ... to improve the software that drives everyday life. , ... institutions and housed in the Morgridge Institute for Research, ... S&T to advance software security practices by building a ...
(Date:7/14/2014)... Eye tests could be used to identify people in ... suggest. In one study, early results from 40 ... significant association between levels of beta-amyloid plaques in the ... in the brain. Beta-amyloid plaques in the brain are ... test could be used in conjunction with the brain ...
(Date:7/14/2014)... HealthDay Reporter MONDAY, July 14, ... to multiple health issues, but dementia isn,t one of them, ... may even delay dementia, the researchers found. "For those ... associated with a later age of developing full-blown dementia compared ... Woodruff. Woodruff, an assistant professor of neurology at ...
(Date:7/14/2014)... KeyPoint Credit Union is teaming up with ... and one-mile family fun walk. The run begins inside ... finishes inside Levi’s® Stadium. , Over the past five ... Mission City Community Fund. All proceeds benefit education, seniors ... athletes, part-time pavement-pounders and walkers are invited to help ...
Breaking Medicine News(10 mins):Health News:Physical fitness associated with less pronounced effect of sedentary behavior 2Health News:Madison-based SWAMP, Secure Decisions partner to enhance software security 2Health News:Madison-based SWAMP, Secure Decisions partner to enhance software security 3Health News:Eye Tests Might Help ID Alzheimer's, Studies Suggest 2Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 2Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 3
... 20 Conseco, Inc. (NYSE: CNO ),today ... rights plan,designed to protect stockholder value by preserving the ... operating loss carryforwards under,Section 382 of the Internal Revenue ... tax assets upon an "ownership change." The rights ...
... study found , , TUESDAY, Jan. 20 (HealthDay News) -- ... exercise, say U.S. researchers. , Dr. Jasmine Grewal, ... with abnormal diastolic function (when the heart is relaxed ... lower maximum capacity for exercise. The left ventricle is ...
... who purchased raw milk from the Conestoga Valley Dairy ... due to the risk of Salmonella contamination, Agriculture Secretary ... pasteurized to kill disease-causing bacteria or homogenized. Pennsylvania farms ... product samples tested in a laboratory due to the ...
... WASHINGTON, Jan. 20 While the U.S. Food and Drug ... affected by last week,s Peanut Corporation of America (PCA) recall ... that national brands of jarred peanut butter are not affected ... ingredients from PCA. , , In addition, ...
... Host Five Cancer Fighters on January 30th for a ... Lillians(TM), The Hippest Shoppe in Town(R) and the ... it will postpone "the dance," its annual fundraising event ... Oct. 23, 2009, at the Medina Entertainment Center.The annual ...
... entails lower risk, speedier recovery, researchers say , , TUESDAY, ... accessing and treating ailing hearts with angioplasty may be ... catheterization technique reduces risk, bleeding, cost and patient recovery ... year, about one million Americans undergo angioplasty to open ...
Cached Medicine News:Health News:Conseco Adopts Stockholder Rights Plan 2Health News:Conseco Adopts Stockholder Rights Plan 3Health News:Conseco Adopts Stockholder Rights Plan 4Health News:Conseco Adopts Stockholder Rights Plan 5Health News:Lillians(TM) Postpones 'The Dance' Fundraising Event; New Date Is October 23, 2009 2Health News:Angioplasty Via Wrist May Be Safer 2
(Date:7/11/2014)... , July 11, 2014  Australian drug delivery ... that it has raised A$19.3 million via a placement ... Europe , the U.S., Asia ... million from a share purchase plan (SPP) to be ... will be made in two tranches. "This ...
(Date:7/11/2014)... July 11, 2014 According to ... "Endoscopy Devices Market (Endoscopes, Endoscopic Operative Devices, and Visualization ... and Forecast, 2013-2019" the global endoscopy devices market was ... expected to grow at a CAGR of 6.8% from ... USD 36.9 billion in 2019. Browse the ...
(Date:7/11/2014)... , July 11, 2014  Veran Medical ... announced today the positive, cost-effective final results ... SPiNPerc™ procedure. The SPiNPerc endobronchial percutaneous biopsy ... percutaneous approach to biopsy when a traditional ... and physicians experience positive financial outcomes when ...
Breaking Medicine Technology:Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Veran Medical Publishes Lung Cancer Patient Management Study 2
MediNotes e is an EMR design which utilizes a "tab concept for navigation. MediNotes e can display multiple patients, encounter notes, workflow items, patient flow, messages, alerts, and more, all in...
... Pro Software developed a touchscreen EHR and ... While a user can choose to use ... to maintain eye contact while recording encounter ... Pro EHR also runs on a pen ...
... Anasazi Clinicians HomePage is a comprehensive on-line ... helps you by reducing your time and ... to concentrate on the clients quality of ... completes a chart audit and shows you ...
... The GE RecordsTFC System ... Registration and other patient/resident record ... approach. It supports multiple facilities ... outpatient and ambulatory clinics, community ...
Medicine Products: