Navigation Links
Drug for erectile dysfunction improves heart function in young heart-disease patients
Date:11/18/2009

Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

Single-ventricle defects are a collection of cardiac malformations that impair the heart's ability to pump blood. Examples include tricuspid atresia, pulmonary atresia/intact ventricular septum and hypoplastic left heart syndrome.

The Fontan operation is a procedure that redirects systemic venous blood directly to the pulmonary arteries, bypassing the heart. It is the third surgery in a staged palliation for single-ventricle heart defects.

Researchers hypothesized that sildenafil may help cardiac performance by directly improving the squeeze of the heart muscle and by allowing for better filling of the heart.

In this study, researchers randomized 28 children and young adults who had undergone the Fontan operation to receive placebo or sildenafil three times a day for 6 weeks. After a 6-week break, subjects were switched to the opposite treatment course. The researchers found significant improvement in heart performance during treatment with sildenafil.

"The enhanced heart performance may improve exercise performance and quality of life in these children and young adults," said David J. Goldberg, M.D., pediatric cardiologist at The Children's Hospital of Philadelphia, who presented the abstract on Nov. 17 at the American Heart Association Scientific Sessions in Orlando, Fla.


'/>"/>

Contact: Joey McCool Ryan
McCool@email.chop.edu
267-426-6070
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1

Related medicine news :

1. ESAI provides grant to LA BioMed to investigate long-term correction of erectile dysfunction
2. Topical Cream for Erectile Dysfunction Shows Promise
3. Enlarged Prostate and Erectile Dysfunction Are Subjects of Free Mens Health Seminar
4. Tadalafil May Effectively Treat Symptoms of BPH-LUTS in Addition to Erectile Dysfunction
5. Tadalafil may effectively treat symptoms of BPH-LUTS in addition to erectile dysfunction
6. For Erectile Dysfunction, Physicians Indicate That Opportunity Exists for Emerging Therapies with Improved Efficacy in Difficult-to-Treat Patient Subpopulations
7. Motorcycle Seats NOT The Cause of Impotence or Erectile Dysfunction for Bikers
8. Rapid Generic Erosion of Branded Agents, Including Market-Leading Viagra, Will Cause Sales of Erectile Dysfunction Drugs to Remain Flat Over the Next Decade
9. Warner Chilcott and Dong-A Sign U.S. License Agreement For Erectile Dysfunction Treatment
10. Despite Sagging Economy, Viamedic Reports Solid Online Sales for Erectile Dysfunction Drugs
11. Hispanic Men Face Elevated Risk of Erectile Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2017)... ... July 29, 2017 , ... Sunshine Coast ... treatment programs in British Columbia, Canada, is proud to announce it has achieved ... as a form of public outreach to showcase its innovative non-12 step methodology ...
(Date:7/28/2017)... ... July 28, 2017 , ... Mirror Mirror ... Crystal Rewards Program, the most successful CoolSculpting practices across the country are annually ... has achieved the coveted Diamond Level status, the highest ranking possible. , ...
(Date:7/28/2017)... ... July 28, 2017 , ... The Military Family Initiative (MFI), ... announced the grant recipients of its inaugural community outreach grant program. , ... , Falcon’s Landing Chapter, Sterling, Va.: $5,000. Community Veterans Collaboration. , ...
(Date:7/28/2017)... ... July 28, 2017 , ... The Aesthetic Surgery Center ... in the “2017 Best Plastic/Cosmetic Surgeon” category. Dr. Anurag Agarwal, Dr. Richard Maloney, ... The SWFL Choice Awards directly reflect the opinion of Florida residents and is sponsored ...
(Date:7/28/2017)... ... July 28, 2017 , ... Nominated ... Supply Chain Partners for 2017. MEBC received numerous client nominations from customers ... Brad Berger, SupplyChainBrain’s publisher, says “For 15 years running, SupplyChainBrain has published our ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... 2017  Endo International plc (NASDAQ: ENDP ... of its manufacturing network, the Company will be ceasing ... Huntsville, Alabama . The closure of ... next 12 to 18 months. The Huntsville ... of commoditized products and these restructuring actions are intended ...
(Date:7/20/2017)...  Prime Therapeutics LLC (Prime) released this statement from its ... Institute for Clinical and Economic Review,s (ICER) public meeting ... value of abuse-deterrent formulations (ADF) of opioids. Prime was the ... meeting. "The ICER ... the use of abuse-deterrent formulations (ADF) in opioids in terms ...
(Date:7/17/2017)... -- MedX Holdings, Inc., the manufacturer and global distributor of ... today announced the national roll out of its MedX ... standard for the treatment of low back injuries and ... How it works: MedX ... who prescribe the MedX Home Back Machine Program for ...
Breaking Medicine Technology: