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Drug-eluting stents confirmed safe, effective for long-term use
Date:8/18/2010

Researchers at the Rabin Medical Center in Israel have determined that the use of drug-eluting stents (DES) improves the long-term clinical outcome for patients undergoing percutaneous coronary intervention (PCI), commonly known as angioplasty. Results of this study appear in the September issue of Catheterization and Cardiovascular Interventions, a journal published by Wiley-Blackwell on behalf of The Society for Cardiovascular Angiography and Interventions.

PCI is used to treat coronary artery disease and is one of the most common medical procedures. Expert reports indicate there were 1,313,000 PCI/angioplasties conducted in the U.S. in 2006. Randomized clinical trials indicate DES decreases in-stent restenosis and the frequency of repeat revascularization procedures in patients undergoing PCI, yet questions remain about the long-term safety and/or effectiveness of DES in routine clinical practice among large unselected population cohorts.

In the current study, the Israeli team examined the benefits and long-term risks of DES by evaluating the established pattern of DES versus bare-metal stent (BMS) use in routine clinical practice in Israel. Israeli guidelines established by the Israel Heart Society and the Ministry of Health require DES be used preferentially in proximal main vessels, diabetic patients, and in long lesions to reduce restenosis.

The study population comprised all consecutive cases of PCI with stent implantation over a 4-year period at the two hospitals of the Rabin Medical Center. The entire cohort consisted of 6,583 patients, 2,633 (40%) patients with a DES and 3,950 (60%) patients with BMS. The minimal follow-up time was 6 months, and the maximal follow-up time was 5.2 years, with a mean follow-up time of 3 years. Propensity score matching and stratified analysis was used to define the clinical effectiveness and safety profile of DES versus BMS among ''all comers'' patients treated at the Center, using
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Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

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