Navigation Links
Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
Date:4/17/2008

In a discovery that may be useful for maintaining remission in chemo-resistant ovarian cancer, Yale scientists report that pre-clinical studies have shown the drug compound NV-128 can induce the death of ovarian cancer cells by halting the activation of a protein pathway called mTOR.

Gil Mor, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, and associate research scientist Ayesha Alvero, M.D. presented the data April 15 during an oral presentation at the annual meeting of the American Association for Cancer Research.

In cancer cells, mTOR signals enhance tumor growth and may be associated with resistance to conventional therapies. Inhibition of mTOR could shut down many of these survival pathways, including proteins that protect the mitochondria of cancer cells.

NV-128, developed by Novogen Limited, holds promise as a more targeted therapy for ovarian cancer because it works differently from traditional therapies that are dependent on enzymes known as caspases to trigger cell death. Therapies using caspases to kill cancer cells can be ineffective in chemo-resistant cancer cells due to mutations that short-circuit signals that trigger cancer cell death.

We consider that the capacity of NV-128 to trigger caspase-independent cell death, in otherwise chemoresistant ovarian cancer cells, opens new possibilities for the use of NV-128 as a potential addition to conventional chemotherapy targeting ovarian cancer cells, said Mor.

In the context of developing therapies for late stage ovarian cancer, Mor said, the finding may be a key step to the development of alternative targeted therapy for patients with cancer recurrence.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Page: 1

Related medicine news :

1. AWWA Urges Science-Based Approach in Addressing Pharmaceutical Compounds in Water
2. The good and bad side of anti-cancer compounds
3. Study validates Pittsburgh Compound-B in identifying Alzheimers disease brain toxins
4. WRAIR investigators pioneering work on an exciting new class of antimalarial compounds
5. Soy compound may halt spread of prostate cancer
6. Drosophila drug screen for fragile X syndrome finds promising compounds and potential drug targets
7. Stevens chemists identify compounds to lure nutria, a rat-like pest ravaging Gulf Coast wetlands
8. Lixte Biotechnology Holdings, Inc. Announces Further Developments Regarding the Anti-Cancer Activity of Its Patent-Pending Proprietary Compounds
9. Researcher of the University of Navarra discovered potential antidepressant compounds
10. DDT Compound Speeds Breast Cancer Growth
11. Novel compound may lessen heart attack damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
(Date:7/26/2017)... ... July 26, 2017 , ... Evergreen Healthcare Partners is ... continued efforts to provide innovative offerings to their healthcare partners. These solutions will ... dynamic, high-performing teams to address healthcare IT’s biggest challenges. , “Adding Talent Management ...
(Date:7/26/2017)... ... ... may be hard to imagine that the basic necessities that developed countries take for ... developed countries consider rare or eradicated, like measles, are still a rite of passage ... segment of "Success Files", actor Rob Lowe will introduce a new segment that will ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... will host its 2017 Process Validation and Process Validation Statistics Conferences in ... to process validation lifecycle challenges faced by process validation professionals and statisticians ...
(Date:7/26/2017)... Newport Beach, CA 92660 (PRWEB) , ... ... ... of Data Loss Prevention for on-premises, off and in the cloud ; today ... intelligent detection and scientific algorithms within a simple to use control console for ...
(Date:7/26/2017)... ... July 26, 2017 , ... “We are thrilled to be partnering with Six ... schedule an appointment online in real time,” said Keith English, LocalMed CEO. “Allowing patients ... will bring more Six Month Smiles patients to their providers.” , Each month, over ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... Mich. , July 13, 2017  Centurion Medical Products, a ... its DisImpactor ® fecal impaction removal device for hospice patient ... ... Patient pain management and ... for Hospice can help alleviate patient pain while preventing unneeded emergency ...
(Date:7/11/2017)... IRVINE, Calif. , July 11, 2017 Zymo Research Corp., ... new service that can quantify biological aging in a precise manner using ... Dr. Steve Horvath , a professor of human genetics and biostatistics ... Fielding School of Public Health , Zymo Research,s proprietary DNAge ™ ... loci. ...
(Date:7/11/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... development of oral drug delivery systems, announced today that ... to schedule an End-of-Phase II meeting with Oramed for ... insulin capsule ORMD-0801 in the treatment of type 2 ... endpoints by indicating a statistically significant lowering of glucose ...
Breaking Medicine Technology: