Navigation Links
Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
Date:4/17/2008

In a discovery that may be useful for maintaining remission in chemo-resistant ovarian cancer, Yale scientists report that pre-clinical studies have shown the drug compound NV-128 can induce the death of ovarian cancer cells by halting the activation of a protein pathway called mTOR.

Gil Mor, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, and associate research scientist Ayesha Alvero, M.D. presented the data April 15 during an oral presentation at the annual meeting of the American Association for Cancer Research.

In cancer cells, mTOR signals enhance tumor growth and may be associated with resistance to conventional therapies. Inhibition of mTOR could shut down many of these survival pathways, including proteins that protect the mitochondria of cancer cells.

NV-128, developed by Novogen Limited, holds promise as a more targeted therapy for ovarian cancer because it works differently from traditional therapies that are dependent on enzymes known as caspases to trigger cell death. Therapies using caspases to kill cancer cells can be ineffective in chemo-resistant cancer cells due to mutations that short-circuit signals that trigger cancer cell death.

We consider that the capacity of NV-128 to trigger caspase-independent cell death, in otherwise chemoresistant ovarian cancer cells, opens new possibilities for the use of NV-128 as a potential addition to conventional chemotherapy targeting ovarian cancer cells, said Mor.

In the context of developing therapies for late stage ovarian cancer, Mor said, the finding may be a key step to the development of alternative targeted therapy for patients with cancer recurrence.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Page: 1

Related medicine news :

1. AWWA Urges Science-Based Approach in Addressing Pharmaceutical Compounds in Water
2. The good and bad side of anti-cancer compounds
3. Study validates Pittsburgh Compound-B in identifying Alzheimers disease brain toxins
4. WRAIR investigators pioneering work on an exciting new class of antimalarial compounds
5. Soy compound may halt spread of prostate cancer
6. Drosophila drug screen for fragile X syndrome finds promising compounds and potential drug targets
7. Stevens chemists identify compounds to lure nutria, a rat-like pest ravaging Gulf Coast wetlands
8. Lixte Biotechnology Holdings, Inc. Announces Further Developments Regarding the Anti-Cancer Activity of Its Patent-Pending Proprietary Compounds
9. Researcher of the University of Navarra discovered potential antidepressant compounds
10. DDT Compound Speeds Breast Cancer Growth
11. Novel compound may lessen heart attack damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
(Date:4/18/2015)... 18, 2015 In the past few ... of changes. , "We had to run maintenance on ... changes," said Jennifer Ramirez, the PR Director. "It disrupted ... say that we are back on track after having ... process of changing phone systems which has not allowed ...
(Date:4/18/2015)... 2015 Aureus Medical Group (web: ... physical therapy jobs, has announced that it will ... Physical Therapy Association Annual Conference to be held ... Greenville, SC. , The SCAPTA Annual Conference ... products and services. , Representatives from Aureus ...
(Date:4/18/2015)... French physician and gastronome Anthelme Brillat-Savarin ... he uttered, “Tell me what you eat, and I ... cope with stress or sadness has often been attributed ... otherwise. Data collected from their Emotional Eating Test ... eating, but for different reasons. , Collecting data from ...
(Date:4/17/2015)... April 18, 2015 Rosetta Radiology is ... rounding out their list of diagnostic imaging services. This ... patients on the Upper East Side of Manhattan. , ... full capacity. The addition of PET-CT, combined with Rosetta’s ... the ability to work with patients through several stages ...
(Date:4/17/2015)... Alcohol and Violence , The National ... drinking and driving has been the focus of much ... the link between alcohol and crime received less public ... and sexual assault, and their relationship to alcohol have ... million adults in America were drinking alcohol at the ...
Breaking Medicine News(10 mins):Health News:TheBeautyPlace.com Temporary Number Available 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3
... Company to Also Present Clinical Data at, ... Upcoming Scientific Meeting ... DDSS ) today announced the publication of Extended Release ... the May 2009 issue of the journal Psychiatry (Edgemont) (Volume 6, ...
... German . , When cells cannot carry out ... is disease. Nanobiotechnology researchers are looking for ways to allow ... absent from the cell. This requires transport systems that can ... controlled fashion at the right moment. The transporter must be ...
... May 19 The Pharmaceutical Research and Manufacturers of ... in the research pipeline for diabetes. The report shows ... a record 183 new diabetes medicines. The medicines listed ... trials or are awaiting approval by the U.S. Food ...
... Lilly with Medtronic delivery and glucose sensing leadership INDIANAPOLIS ... recognized names in diabetes management -Eli Lilly and Company ... MDT ) - today announced a strategic ... people with diabetes manage their blood sugar using insulin ...
... Veterinary Care Digital Imaging and Data Management Providers ... Eklin Medical Systems, a leading provider of ... Communications Systems) and practice management software (VIA(R)) for ... Thorn as the company,s West Coast ultrasound representative. ...
... improve our understanding of conditions such as epilepsy and ... University have discovered. , Research by a team ... has discovered that a person,s brain produces a unique ... looks at a visual pattern. , Importantly, the ...
Cached Medicine News:Health News:Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal 2Health News:Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal 3Health News:Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal 4Health News:Capsules encapsulated 2Health News:New Report Released in North Carolina Shows Record Number of Medicines in Development to Treat Diabetes 2Health News:New Report Released in North Carolina Shows Record Number of Medicines in Development to Treat Diabetes 3Health News:New Report Released in North Carolina Shows Record Number of Medicines in Development to Treat Diabetes 4Health News:Lilly and Medtronic Form Alliance to Provide Solutions for Diabetes Management 2Health News:Lilly and Medtronic Form Alliance to Provide Solutions for Diabetes Management 3Health News:Lilly and Medtronic Form Alliance to Provide Solutions for Diabetes Management 4Health News:Eklin Medical Systems Appoints Juan Thorn as West Coast Ultrasound Sales Representative 2Health News:'Singing brains' offers epilepsy and schizophrenia clues 2
(Date:4/16/2015)... 2015  Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ) will ... on Wednesday, May 6, 2015, following the close of the ... conference call and live webcast on the same day at ... discuss the financial results.  To access the ... the "Investors" link.  Please log onto the webcast prior to ...
(Date:4/16/2015)... Kenneth C. Frazier , chairman and chief executive officer ... the Board of the Pharmaceutical Research and Manufacturers of America ... John J. Castellani announced that he will be retiring ... to PhRMA Board Frazier formerly held the position ... and CEO of Pfizer, Inc. Also elected were George ...
(Date:4/16/2015)... YORK , April 16, 2015 An ... additional way to generate trimers from the major HIV ... could benefit future clinical development of HIV vaccine candidates ... the critical target on the surface of HIV for ... an important platform for AIDS vaccine discovery, says ...
Breaking Medicine Technology:Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 2Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 3Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 2Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 3Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 4Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 5New Method Holds Promise for HIV Vaccine Development 2
... Corporation (Nasdaq: GNBT, www.generex.com ), the leader in ... of the mouth, today announced that it has been ... Canadian Intellectual Property Office granted Canadian Patent No. 2,401,942, ... Application". This new patent increases the number ...
... International Corporation (Nasdaq: PRXL ) announced today it ... Conference in New York.  James Winschel, Senior Vice President and ... at 11:45 a.m. ET on Tuesday, October 5, 2010. ... through the "Investors" section of PAREXEL,s website at ...
Cached Medicine Technology:Generex Awarded a New Patent in Canada for its Proprietary Buccal Drug Delivery System 2Generex Awarded a New Patent in Canada for its Proprietary Buccal Drug Delivery System 3PAREXEL International to Present at William Blair Emerging Growth Stock Conference 2
... Meet All Nearpoint Testing Needs, ... Horizontal and Vertical Phoria, Binocular ... Visual Acuity Horizontal Fixation Disparity, ... Cylinder, Random Dot Stereopsis Monocular ...
Pediatric: Tumbling "E" Acuity, Binocular Balance, Supression, Fixation Disparity, Stereopsis...
Adult: Letter Acuity, Number Acuity, and Tumbling E Tests....
... is a serine protease that is,found only ... of the,acini and ducts. Normal PSA concentration ... Reports have suggested that elevated,level of whole ... useful tumor,markers in diagnosis of prostate cancers. ...
Medicine Products: