Navigation Links
Drug combo better for common type of metastatic breast cancer, UCI-led study finds
Date:8/1/2012

Irvine, Calif. Postmenopausal women with the most common type of metastatic breast cancer now have a new treatment option that lengthens their lives, according a study led by UC Irvine oncologist Dr. Rita Mehta and conducted by the Southwest Oncology Group. The findings appear in the Aug. 2 issue of the New England Journal of Medicine.

A combination of the two anti-estrogen drugs anastrozole and fulvestrant extended the median survival time of women with Stage 4 hormone receptor-positive metastatic breast cancer by more than six months compared to those who underwent standard treatment with anastrozole alone.

Mehta said the results of the Phase 3 trial are particularly exciting because "these patients have not had a new treatment that gave them an overall survival benefit in more than a decade."

Both drugs are currently used to treat breast cancer, though not in combination. Anastrozole (also known as Arimidex) reduces the production of tumor-promoting estrogen, while fulvestrant (Faslodex) interferes with the receptors that allow estrogen to signal cells to grow and reproduce and also accelerates the degradation of these receptors.

The researchers think it's these modes of action together that make the combination so effective against hormone receptor-positive breast cancer, a subtype that accounts for more than half of all breast cancers.

"The next step would be to try the combination in even earlier stages of breast cancer to see whether long-term cures could be increased at those stages," said Mehta, an associate clinical professor of medicine with the Chao Family Comprehensive Cancer Center and an oncologist with UC Irvine's Breast Health Center.

Study results were first presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium in December. The SWOG S0226 trial was conducted by the SWOG clinical trials network, previously known as the Southwest Oncology Group.


'/>"/>
Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1

Related medicine news :

1. Experimental Chemo Combo for Colon Cancer Disappoints
2. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
3. Two-Drug Combo Helps Teens With Migraines
4. Two-Drug Combo May Be Safe for Melanoma Treatment
5. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
6. Combo Therapy May Help Ease Ringing in the Ears
7. FDA Approves Combo Shot for Meningitis, Hib in Kids
8. Booze, Energy Drinks, Casual Sex Combo Common in College: Study
9. A better tool to diagnose tuberculosis
10. Job injuries among youth prompt calls for better safety standards
11. Students focus on creating a better cervical collar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Va. (PRWEB) August 22, 2014 On ... Center for Medical and Health Sciences , hosting a ... area’s top influencers in government and public welfare. , ... College of Osteopathic Medicine (LUCOM) joined Liberty staff, ... and the launch of the new medical school. Classes ...
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... authentic content that is written by marketing experts for ... and affiliate links has caught the attention of Shane ... is involved with Internet marketing in any way knows ... or failure in the industry,” reports Michaels. “But even ...
(Date:8/22/2014)... 2014 Japantown Dental is excited to ... whitening technique. Air polishing is a technique used to ... teeth can be caused by a number of factors, ... internal stains. External stains include coffee, wine, tea, smoking ... certain medications, such as tetracycline, and direct trauma to ...
(Date:8/22/2014)... team has found that targeted automated alerts in ... in hospital patients with urinary catheters. In addition, ... the rate of improvement dramatically increased. , The ... urinary catheters in the first place and then ... that have not been removed within a recommended ...
(Date:8/22/2014)... NV (PRWEB) August 22, 2014 Natural ... Kevin Richardson to restore his own vision from legally blind ... Michaels, prompting an investigative review. , “There is a ... or contacts for everyday function, and most people just think ... to corrective eye surgery that can be pretty risky at ...
Breaking Medicine News(10 mins):Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 2Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 3Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 4Health News:My Writers: Review Exposes Online Source for Quality Marketing Content 2Health News:Japantown Dental Introduces Air Polishing 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 3Health News:Natural Clear Vision: Review Exposes Kevin Richardson’s Program for Restoring Vision Naturally 2
... Inaugural Gala, NORTH ADAMS, Mass., Nov. 14 ... today announced that it will hold,its first Roundtable meeting ... Institute, established by NPSF in May 2007, is a,think ... action for,the field of patient safety. Its goal is ...
... , Ohio -- Scientists are one step closer to ... for supporting life. , For the first time, scientists ... protein molecules to enable different functions to happen. , ... of the Proceedings of the National Academy of Sciences, ...
... your name and initials? Most people do and, as past ... other important behaviors. For example, Jack is more likely to ... is more likely to move to Philadelphia and marry Phyllis. ... it is influential enough to encourage the pursuit of name-resembling ...
... in the World Journal of Gastroenterology on November 7, ... case of gastric carcinosarcoma obtained in this part of ... Tomislav Randjelovic as surgeon and Dr. Branka Filipovic as ... his team; the anatomical and patoanatomical evaluation of macroscopic ...
... Asenapine -- a fast-,dissolving, sublingual tablet being ... and well-tolerated in patients with acute schizophrenia,according to ... of the Journal,of Clinical Psychiatry. These data were ... meeting and at the annual,congress of the European ...
... International,Isotopes Inc. (OTC Bulletin Board: INIS) is pleased ... Chief Financial Officer (CFO),effective November 13, 2007. ... 2007,as Chief Accounting Officer. Ms. McKenzie-Carter has approximately ... Previously, she served as,chief accountant for a sizeable ...
Cached Medicine News:Health News:Lucian Leape Institute Announces First Roundtable 2Health News:Lucian Leape Institute Announces First Roundtable 3Health News:Scientists get first look at how water 'lubricates' proteins 2Health News:What's in a name? Initials linked to success, study shows 2Health News:Study Shows Organon's Asenapine Demonstrates Efficacy and Tolerability in Treating Acute Schizophrenia 2Health News:Study Shows Organon's Asenapine Demonstrates Efficacy and Tolerability in Treating Acute Schizophrenia 3Health News:Study Shows Organon's Asenapine Demonstrates Efficacy and Tolerability in Treating Acute Schizophrenia 4Health News:Laurie McKenzie-Carter Named Chief Financial Officer of International Isotopes Inc. 2
(Date:8/22/2014)... Ireland , August 22, 2014 /PRNewswire/ ... and Markets ( http://www.researchandmarkets.com/research/x34qgv/global_laboratory ) has announced the ... Market 2014-2018"  report to their offering.  ... balance is an essential instrument for any ... the precise weighing of materials. It can ...
(Date:8/22/2014)...  Diplomat, the nation,s largest independent specialty pharmacy, ... in the 2014 Innovations in Specialty Pharmacy Competition, ... of the competition were announced in the August ... Diplomat was honored as a Top Innovator ... Through Diplomat University, the company has implemented a ...
(Date:8/22/2014)... , Aug. 22, 2014 Research ... "Stem Cell Research Products: Opportunities, Tools & Technologies" ... already supply stem cell research products or you wish ... essential and lucrative this market is. The authors know ... sell more effectively to scientists, to generate improved revenues ...
Breaking Medicine Technology:Global Laboratory Electronic Balance Market 2014-2018: Key Vendors are A&D Company, Mettler-Toledo, Sartorius and Thermo Fisher 2Diplomat honored as a Top Innovator by Specialty Pharmacy News 2Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 2Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 3
... 2011 Bayer HealthCare Pharmaceuticals Inc. today ... cohort safety study offer insights into the increased risk ... a well-established risk in women who use combination oral ... Specifically, the new data provides healthcare providers with information ...
... Therapeutics today announced  the initiation of a Phase ... XMT-1001 , a novel DNA topoisomerase I inhibitor based ... in second-line gastric cancer and second-/third-line non-small cell lung ... clinical centers in the US.  The Phase 1b follows ...
Cached Medicine Technology:New Interim Data About Combination Oral Contraceptives 2New Interim Data About Combination Oral Contraceptives 3New Interim Data About Combination Oral Contraceptives 4New Interim Data About Combination Oral Contraceptives 5New Interim Data About Combination Oral Contraceptives 6Mersana Therapeutics Initiates Phase 1b Extension Study of XMT-1001 in Gastric Cancer and Non-Small Cell Lung Cancer 2Mersana Therapeutics Initiates Phase 1b Extension Study of XMT-1001 in Gastric Cancer and Non-Small Cell Lung Cancer 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: