Navigation Links
Drug combinations key in treating neurodegenerative diseases

AUGUSTA, Ga. Combining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases, Medical College of Georgia researchers say.

Drugs that protect neurons, for example, can be used with those targeting memory to make real progress in treating diseases such as Alzheimer's, says Dr. Jerry Buccafusco, founding director of the MCG Alzheimer's Research Center.

"We realize that with neurodegenerative diseases there will not be one magic bullet," Dr. Buccafusco says. "Developing new therapeutics will require an attack on many different levels. But, right now, there are no FDA-approved compounds out there that are significantly disease-modifying. We're at the point where we're just getting to that."

His review of trends in pharmacological research of neurodegenerative diseases is the featured article in the January issue of NeuroTherapeutics, the journal of the American Society for Experimental NeuroTherapeutics.

Alzheimer's treatment, for instance, should combine molecules that protect neurons from plaque buildup with approved therapies like cholinesterase inhibitors, which treat cognition and memory loss, Dr. Buccafusco says.

Dr. Buccafusco also cited several novel drug candidates developed at the MCG Alzheimer's Research Center, including two molecules prevent cell death in the brain and improve cognition, reaction time and attention.

"What we have to do now is look at drugs that have already been developed to address very specific disease targets and come up with new ways to combine constituent groups of active molecules into a single therapeutic agent," Dr. Buccafusco says. "Drugs should target more than one particular molecular structure and molecular receptor in the central nervous system. The technology is available to design molecules that have multiple properties all in one package. This approach could represent a new frontier for pharmacology."

Advantages to multi-functional drug compounds, he says, include fewer side effects.


Contact: Jennifer Hilliard
Medical College of Georgia

Related medicine news :

1. Scientists call up stem cell troops to repair the body using new drug combinations
2. Drug Combinations Putting Seniors at Risk
3. Single-Pill Combinations Diovan HCT and Exforge Approved in US as First-Line Treatments for High Blood Pressure
4. Do bacterial combinations result in enhanced cytokine production? No!
5. Novartis Oncology Launches GIST Alliance™ for Healthcare Professionals Treating Gastrointestinal Stromal Tumors
6. Breast cancer drug shows promise for treating, preventing progestin-dependent tumors
7. Photos: Apples iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute
8. Older Drug Effective in Treating Pediatric Nerve Cancer
9. ALS TDI and Asklepios to Develop New Therapeutic Delivery Options for Treating Lou Gehrigs Disease
10. Treating gum disease linked to lower medical costs for patients with diabetes
11. Schering-Plough Announces FDA Approval of PEGINTRON(TM) and REBETOL(R) Combination Therapy for Treating Pediatric Hepatitis C
Post Your Comments:
Related Image:
Drug combinations key in treating neurodegenerative diseases
(Date:11/30/2015)... ... November 30, 2015 , ... 1Heart Caregiver ... of the Federation of Philippine American Chambers of Commerce held from November 6-8, ... , 1Heart Caregiver Services, as an active delegate from the Philippine American Chamber ...
(Date:11/30/2015)... , ... November 30, 2015 , ... Until now, the ... set forth in the MOMS (Management of Myelomeningocele Study) trial. One of these exclusion ... and Prevention), a BMI of 18.5 to 24.9 is considered normal, 25 - 29.9 ...
(Date:11/30/2015)... ... ... According to research by the National Association of Dental ... certified or obtain continuing education. To increase awareness of the lack of standards ... inform dentists that the technicians they trust could lack the skills and knowledge ...
(Date:11/30/2015)... Fla. (PRWEB) , ... November 30, 2015 , ... MOSI ... Land, and Sea along with Back to the Jurassic to their collection of interactive ... INDE has created dynamic worlds that will allow guests to get closer than ever ...
(Date:11/30/2015)... ... November 30, 2015 , ... In ... Halloween festivities, the Word of Life Christian Church of Flint, MI, hosted a ... a giant 1.25 ton pile of candy dubbed “Candy Mountain”. , A Forever ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... SAN DIEGO , Nov. 30, 2015 ... ARNA ) today announced that the U.S. Food ... New Drug Application (NDA) for an extended release formulation ... offer patients a chronic weight management treatment in a ... currently approved as an adjunct to a reduced-calorie diet ...
(Date:11/30/2015)... MOUNTLAKE TERRACE, Wash. and ST. ... Cross and Express Scripts (NASDAQ: ESRX ) today ... benefit agreement. The partnership, which began in 1999, will ... --> --> After evaluating pharmacy ... process, Premera concluded that Express Scripts continues to offer ...
(Date:11/30/2015)... N.H. , Nov. 30, 2015 ... that it will feature its latest solutions for ... early identification of cancer at the Radiological Society ... Chicago from November 29 ... recent product advances including iReveal®, an automated breast ...
Breaking Medicine Technology: