Navigation Links
Drug combinations key in treating neurodegenerative diseases
Date:1/30/2009

AUGUSTA, Ga. Combining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases, Medical College of Georgia researchers say.

Drugs that protect neurons, for example, can be used with those targeting memory to make real progress in treating diseases such as Alzheimer's, says Dr. Jerry Buccafusco, founding director of the MCG Alzheimer's Research Center.

"We realize that with neurodegenerative diseases there will not be one magic bullet," Dr. Buccafusco says. "Developing new therapeutics will require an attack on many different levels. But, right now, there are no FDA-approved compounds out there that are significantly disease-modifying. We're at the point where we're just getting to that."

His review of trends in pharmacological research of neurodegenerative diseases is the featured article in the January issue of NeuroTherapeutics, the journal of the American Society for Experimental NeuroTherapeutics.

Alzheimer's treatment, for instance, should combine molecules that protect neurons from plaque buildup with approved therapies like cholinesterase inhibitors, which treat cognition and memory loss, Dr. Buccafusco says.

Dr. Buccafusco also cited several novel drug candidates developed at the MCG Alzheimer's Research Center, including two molecules prevent cell death in the brain and improve cognition, reaction time and attention.

"What we have to do now is look at drugs that have already been developed to address very specific disease targets and come up with new ways to combine constituent groups of active molecules into a single therapeutic agent," Dr. Buccafusco says. "Drugs should target more than one particular molecular structure and molecular receptor in the central nervous system. The technology is available to design molecules that have multiple properties all in one package. This approach could represent a new frontier for pharmacology."

Advantages to multi-functional drug compounds, he says, include fewer side effects.


'/>"/>

Contact: Jennifer Hilliard
jhilliard@mcg.edu
706-721-8604
Medical College of Georgia
Source:Eurekalert  

Related medicine news :

1. Scientists call up stem cell troops to repair the body using new drug combinations
2. Drug Combinations Putting Seniors at Risk
3. Single-Pill Combinations Diovan HCT and Exforge Approved in US as First-Line Treatments for High Blood Pressure
4. Do bacterial combinations result in enhanced cytokine production? No!
5. Novartis Oncology Launches GIST Alliance™ for Healthcare Professionals Treating Gastrointestinal Stromal Tumors
6. Breast cancer drug shows promise for treating, preventing progestin-dependent tumors
7. Photos: Apples iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute
8. Older Drug Effective in Treating Pediatric Nerve Cancer
9. ALS TDI and Asklepios to Develop New Therapeutic Delivery Options for Treating Lou Gehrigs Disease
10. Treating gum disease linked to lower medical costs for patients with diabetes
11. Schering-Plough Announces FDA Approval of PEGINTRON(TM) and REBETOL(R) Combination Therapy for Treating Pediatric Hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug combinations key in treating neurodegenerative diseases
(Date:3/28/2017)... ... March 28, 2017 , ... Qualidigm , ... corporate headquarters to a new, more expansive office space in order to accommodate ... purchased a distressed office building in Wethersfield, Conn. located at 936 Silas Deane ...
(Date:3/28/2017)... Petersburg Florida (PRWEB) , ... March 28, 2017 , ... ... Marine Corp to raise money to for the Toys for Tots Literacy Campaign at ... federal budget in excess of $70 billion, the U.S. ranks at number 14 internationally ...
(Date:3/28/2017)... ... March 28, 2017 , ... Public relations pros work hard to ... of business channels. , While many results are clear, much of PR is hard ... , When it comes to measurement, firms should always take an all-inclusive approach that ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... Thank you ... Diego on February 8-10. , This event was exclusive to providers and offered ... , The meeting took place at the Manchester Grand Hyatt where attendees gathered for ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... clear braces. People who want straight teeth without the extensive time commitment and ... Clearwater, FL, without acquiring a referral. A custom-designed series of virtually invisible aligners ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 27, 2017 Therapix Biosciences ... company specializing in the development of cannabinoid-based drugs, today ... the United States of ... 40 ordinary shares of the Company, at a ... has granted the underwriters a 45-day over-allotment option ...
(Date:3/27/2017)... , March 27, 2017 LightIntegra Technology ... appointed William "Bill" Dubiel as President and Chief Executive ... elected to the Board of Directors of LightIntegra. ... Executive Chairman of LightIntegra. "This is ... President and Chief Executive Officer. We,ve selected a very ...
(Date:3/27/2017)... 27, 2017  A new survey from ... Medicare,s Competitive Bidding Program (CBP) significantly reduced beneficiary choice ... lack of choice forces beneficiaries to switch to unfamiliar ... consequences. AADE,s survey is the latest ... others pointing out the inherent problems with the CBP. ...
Breaking Medicine Technology: