Navigation Links
Drug combination improves or stabilizes disease for relapsed multiple myeloma patients
Date:12/9/2008

/bio/11115891.html">http://www.mayoclinic.org/bio/11115891.html), Mayo Clinic hematologist and lead researcher on the study. Also encouraging, says Dr. Lacy, is that treatment did not cause significant side effects in most patients. Side effects included anemia and declines in blood counts, most often mild in both.

In the study, patients took pomalidomide (2 milligrams [mg]) orally daily for a 28-day cycle. Dexamethasone (40 mg) was taken orally on days 1, 8, 15 and 22 of each cycle. Patients also took 325 mg of aspirin daily to prevent blood clots, a concern associated with immunomodulatory agents. Blood clots can occur with use of any IMiD, but the risk increases as the dose of dexamethasone increases.

The dosage of dexamethasone in the current trial is one-third of the dose that was used in the registration trial that led to FDA approval for lenalidomide in previously treated myeloma patients. "We're getting good results with less toxicity compared to what we've seen in the past," says Dr. Lacy. "And, so far, no patients have had blood clots."

Another key finding was that pom/dex was helpful for 29 percent of patients who previously did not respond to treatment with lenalidomide.

"We are excited about the potential of this drug combination to significantly help patients with myeloma," says Dr. Lacy. "Based on these encouraging results, we are expanding the study to include other patient populations that may benefit from this therapy."


'/>"/>

Contact: Amy Tieder
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. European Committee for Human Medicinal Products (CHMP) Issues Positive Opinion for Once-Daily PREZISTA(R) (Darunavir) as Part of Combination Therapy for Treatment-Naive Adults With HIV-1
2. Best Practice Database Provides Benchmarks for Fixed-Dose Combination (FDC) Drug Development
3. Novel 4-drug combination proves safe for lung cancer treatment
4. Poor Sleep, Hypertension a Dangerous Combination
5. New Study Provides Benchmarks for Fixed-Dose Combination (FDC) Drug Development
6. China Pharma Holdings, Inc. to Initiate Clinical Trials For New Antibiotic Combination
7. Prologue Acquisition Update and Termination of Linkcon Business Combination
8. Combination Therapy Helps to Combat Myeloma
9. Particle Sciences Develops Zero-Order-Release Combination Device Technology
10. Single-Pill Combinations Diovan HCT and Exforge Approved in US as First-Line Treatments for High Blood Pressure
11. Highmark and Independence Blue Cross CEOs Say Combination of Highmark and Independence Blue Cross will Provide $1 Billion in New Resources Over Six Years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 Panic attacks are extremely difficult ... of intense stress and fear, which appears with no ... causing insecurity and affecting relationships. , A panic attack ... many symptoms that patients can deal with. Anxiety, shortness ... Overcoming panic attacks is extremely important for sufferers, who ...
(Date:8/29/2014)... 29, 2014 Indosoft, Inc., a leading ... availability of monthly per-port licensing of its Q-Suite 5.7 ... center solutions, Indosoft has been successfully deploying and supporting ... large contact centers around the world for more than ... to give clients another option which complements the widespread ...
(Date:8/29/2014)... 2014 Champion boxers Laila Ali and ... appearing on the annual MDA Show of Strength Telethon ... on ABC television stations across the country. , ... of “All In, with Laila Ali," will introduce a ... the Muscular Dystrophy Association's nationally broadcast show. , Ortiz ...
(Date:8/29/2014)... UWDress.com, one of the most famous dress ... of 2014 floor length bridesmaid dresses . Additionally, ... items. According to the company’s marketing specialist, all its ... rate (up to 60 percent off) before September 10. ... special neckline: strapless, one-shoulder, bateau and more. The main ...
(Date:8/29/2014)... As reported by CNN.com in the article ... of admitting that you need help for a prescription drug ... highlights the fact that if you simply try to find ... by all of the information that is available online. Although ... it is still possible to get help. The statistics from ...
Breaking Medicine News(10 mins):Health News:60 Second Panic Solution Review Exposes Simple Panic Attacks Remedy 2Health News:Indosoft Offers Monthly Usage Licensing Terms 2Health News:Champion Boxers Fight Back Against Muscle Disease 2Health News:Champion Boxers Fight Back Against Muscle Disease 3Health News:2014 Floor Length Bridesmaid Dresses for Sale at UWDress.com 2Health News:What to Know When Seeking Drug Addiction Help 2Health News:What to Know When Seeking Drug Addiction Help 3
... small Pacific Islands, which consists of the some of ... the global conservation map//, and is said to be ... ,Martin Puta Tofinga, Minister of Environment, ... announced the establishment of the Phoenix Islands Protected Area ...
... under the Freedom of Information Act have revealed that hospitals ... use of car parks. The BBC reports that trusts had ... this service. ,The hospitals, which earned the maximum ... The Department of Health figures show that University Hospital Birmingham ...
... in the April issue of Radiology says that ultrasound is ... and also assess// the effectiveness of chemotherapy. Researchers at the ... a study where they examined the largest group of women ... cancer during pregnancy. ,"Ultrasound identified 100 percent of ...
... that promotes body growth, is produced in the brain according ... // The researchers have been able to trace the origin ... the brain in charge of memory and emotion – called ... the fact that more growth hormones are produced in females ...
... on cancer have proposed that cancer patients should be ... their care. // ,National standards in the ... standards could be enforced by the National Institute of ... the aspects of cancer services that would be standardized ...
... alcohol is not a sign that drinkers remain uninfluenced by ... like red bull after alcohol, to maintain sobriety. // ... after drinking vodka mixed with red bull felt less drunk, ... Souza-Formigoni, PhD, in a news release said “The person is ...
Cached Medicine News:Health News:Phoenix Islands To Be Protected Under Global Conservation Map 2Health News:Phoenix Islands To Be Protected Under Global Conservation Map 3Health News:Charging Car Park Fees From Cancer Patients Is Morally Wrong, Says Macmillan Cancer Relief 2Health News:Ultrasound Can Detect Breast Cancer in Pregnant Women 2Health News:Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety? 2
(Date:8/29/2014)... 2014  Pacific Medical Data Solutions is excited to ... . The main website, along with the site,s blog, ... services and content relevant to the medical billing industry. ... viewers can now better understand how PMDS products help ... create a more visible platform about medical billing best ...
(Date:8/29/2014)... , August 29, 2014 ... participate in the inaugural Tweetchat taking place in ... Worldwide , organised by UBM Live , ... #CPhIChat is a first of its kind global ... across the supply chain, aimed to stimulate conversations ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com ... report is available in its catalogue: ... Compliance Services Industry (U.S.): Analytics, Extensive ... to 2021, NAIC 541380 ... Testing Laboratories, Safety and Compliance ...
Breaking Medicine Technology:PMDS Announces New Website 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: