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Drug combination effective against multiple myeloma, researchers show
Date:11/21/2007

Overall, 85.3 percent of those receiving the combination therapy experienced side effects compared with 73.1 percent of the placebo-dexamethasone group. Some of the side effects were serious enough to cause 19.8 percent of the combination group and 10.2 percent of the placebo group to quit the trial.

Major side effects from the combination were suppression of patients' white blood cells, making them vulnerable to infection, and formation of blood clots. In most cases, these side effects were countered by decreasing the lenalidomide dose, or administering antibiotics or anticoagulants.

One of the major side effects of thalidomide - significant nerve pain and numbness in the limbs known as peripheral neuropathy - was nearly absent in the lenalidomide group.


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Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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