Navigation Links
Drug combination effective against multiple myeloma, researchers show
Date:11/21/2007

HOUSTON - Pairing a new thalidomide derivative with a steroid slows progress of multiple myeloma, an incurable bone marrow cancer, and prolongs the lives of patients who have relapsed from previous treatment, researchers report in the Nov. 22 New England Journal of Medicine.

In the study conducted at 44 centers in the United States and Canada, 353 patients with myeloma received either a combination of lenalidomide (Revlimid(r)) and the steroid dexamethasone or dexamethasone plus a placebo.

"Those taking the lenalidomide combination had a median time to disease progression of 11.1 months compared with 4.7 months in the placebo-dexamethasone group and an improved median overall survival time of 29.6 months compared with 20.2 months," says lead author Donna Weber, M.D., associate professor in the Department of Lymphoma and Myeloma at The University of Texas M. D. Anderson Cancer Center.

The results were impressive enough that in December of 2005 an independent interim data analysis resulted in the trial being halted early so those on placebo-dexamethasone could also benefit from the addition of lenalidomide.

The collaborative study by North American Multiple Myeloma Study Investigators, and an international trial also reported in the New England Journal of Medicine, led to the approval of lenalidomide and dexamethasone for previously treated patients by the U.S. Food and Drug Administration in 2006.

"These trials highlight how large-scale cooperation in a team effort by myeloma investigators can quickly confirm benefits and introduce new active agents for patients with this disease," Weber says. "We also owe a debt to the willing patients who participated in this study."

Multiple myeloma is caused by formation of abnormal plasma cells, a type of white blood cell, in the bone marrow. These cells multiply rapidly, crowding out normal red and white blood cells and platelets. Tumors starting in the bone marro
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Promising drug combination may help those with ocular melanoma that has spread
2. Combination therapy reverses effects of portal hypertension in rats
3. Combination vaccines okay for infants, study shows
4. Antidepressants and painkillers - a dangerous combination
5. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Drug combination might offer hope for patients deadly brain tumors
8. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
9. Combination targets: some drugs may work best when they work together
10. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
11. Quality Control: Nissan Quest to Feature micronAir(R) Combination Cabin Air Filters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... March 02, 2015 Secura Consultants ... relationship with First Protective Insurance Group of Birmingham, ... allow First Protective affiliated advisors to access the ... that Secura Consultants delivers. , Secura ... leader in the design and implementation of insured ...
(Date:3/1/2015)... March 01, 2015 Women’s Excellence is ... Obstetric terms on their website. There are over 75 ... the time. , “This gives our patients a better ... medical terminology that they may not understand. With this resource, ... is mobile optimized) and find terms and phrases that they may ...
(Date:3/1/2015)... NC (PRWEB) March 01, 2015 Researchers ... reason that so many sheet metal workers contract malignant ... this new report on its website. Click here ... Center for Construction Research and Training monitored 17,345 sheet ... a disproportionate number of them died of mesothelioma ...
(Date:3/1/2015)... 01, 2015 Indiana Fiber Network, ... Provider, announces NewWays Networking, LLC (NewWays) selected IFN ... with IFN, NewWays is well positioned to scale ... for Internet bandwidth in rural parts of Indiana,” ... to Cory Childs IFN Enterprise Sales Manager, IFN ...
(Date:3/1/2015)... Vancouver, WA (PRWEB) February 28, 2015 CrossFit ... This spring they are offering a special discount to new ... who sign up for a three month contract will receive ... each month individually would cost members $440. The three ... $88 per month, and then the fourth month comes in ...
Breaking Medicine News(10 mins):Health News:Secura Consultants and First Protective Insurance Group Announce Strategic Relationship 2Health News:New Study Finds Indirect Asbestos Exposure Can Raise Mesothelioma Risk for Sheet Metal Workers, According to Surviving Mesothelioma 2Health News:NewWays Networking Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2
... was no better than placebo, study finds , , MONDAY, ... (Trileptal) does not seem to prevent migraines, as once ... than 28 million Americans, and certain epilepsy drugs have ... headaches. For this reason, many assumed that oxcarbazepine would ...
... at Annual Meeting of the American Academy of ... ... NeoStrata today released new,clinical data that demonstrates significant benefits in combining,microdermabrasion ... products in improving the appearance,and texture of facial skin. The data ...
... for donations is spiraling for older couples wanting to start ... ... Radical shifts in parenting,trends have fertility experts at Reproductive Endocrinology Associates of,Charlotte ... in 2008 -- including new outreach through the Internet --,in efforts to ...
... the day that we,celebrate love approaches, many people with memory-impaired ... sustain a loving,relationship with someone who no longer knows who ... a new understanding of love itself., "It,s important to ... matters most is doing things that make him or her ...
... Show All 89 Inspected Pennsylvania Facilities Meet Federal,Standards, ... of,Environmental Protection reported today that all of the ... are operating within,the guidelines set forth by the ... each of Pennsylvania,s approximately 400 certified,mammography facilities annually ...
... saturate TV, radio, and print with anti-Meth ... ... The Illinois Meth Project,today launched a campaign to prevent first-time methamphetamine ... a research-based prevention program that educates people,about the dangers of Meth ...
Cached Medicine News:Health News:Epilepsy Drug Doesn't Prevent Migraines 2Health News:NeoStrata Clinical Findings Reveal Benefits of Combining Glycolic Acid Peels and Targeted Home Care With Microdermabrasion for Optimized Treatment of Photodamaged Skin 2Health News:Charlotte IVF Experts Issue Urgent Call for Egg Donors, Eye New Recruiting Tools 2Health News:Loving the Memory-Impaired: A New Perspective on Valentine's Day 2Health News:Pennsylvania DEP Releases 4th Quarter 2007 Mammography Inspection Results 2Health News:Pennsylvania DEP Releases 4th Quarter 2007 Mammography Inspection Results 3Health News:Pennsylvania DEP Releases 4th Quarter 2007 Mammography Inspection Results 4Health News:Illinois Meth Project Launches Large-Scale Meth Prevention Campaign 2Health News:Illinois Meth Project Launches Large-Scale Meth Prevention Campaign 3Health News:Illinois Meth Project Launches Large-Scale Meth Prevention Campaign 4
(Date:2/27/2015)... YORK , Feb. 27, 2015  Pomerantz LLP ... Pharmaceuticals, Inc. ("Vitae" or the "Company") (NASDAQ: ... Robert S. Willoughby at rswilloughby@pomlaw.com or ... Vitae and certain of its officers and/or directors have ... Act of 1934.  On February 27, ...
(Date:2/27/2015)... 2015 Securities lawyers at Dunnam & ... Ltd. (NASDAQ: SLXP ) in connection with ... investors are encouraged to contact attorney Hamilton Lindley by ... focuses upon the shareholder value of the transaction. Under ... only $158.00 per share in cash. At least one ...
(Date:2/27/2015)... Report Details   ... R&D progress, and predicted revenues ,Where is the market ... commercial prospects for this market and related technologies? Visiongain,s ... trends to 2025, discussing data, opportunities and prospects. ... regenerative medicine : cell-based therapies that aim to restore ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Vitae Pharmaceuticals, Inc. - VTAE 2Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8
... VIEW, Calif., Feb. 23, 2011 Omnicell, Inc ... of medication management systems to healthcare facilities, today announced ... 100 healthcare executives were polled to identify trends in ... purchasing decisions. The survey found that the majority of ...
... Biomatrica, Inc., a leader in room temperature biostability ... In-Q-Tel (IQT). IQT is the independent, strategic investment ... the mission of the U.S. Intelligence Community. ... has pioneered recent innovations in ambient storage of ...
Cached Medicine Technology:75 Percent of Hospital IT Leaders View Interoperability Between Vendor Systems as Critical to Operational Effectiveness in Healthcare Settings 2Biomatrica Secures Strategic Investment from IQT 2Biomatrica Secures Strategic Investment from IQT 3
The Auto Suture™ Woodford Spike™ Trocar and Cannula is a sterile, single-use device designed for primary punctures during laparoscopy. Dexide refers to a separate offering of trocars from...
... line of Surgical Access ...unlike any trocar ... trocar system is actually four systems in ... flexible and clinically adaptive to all of ... disposability and bladed or dilating tip styles, ...
Thoracoscopy Cannula, reusable, hook electrode, two lengths, mini or basic kit....
... we believe that the trocar should be ... instrument precision and speeding the process. So ... trocar that meets the needs of the ... Xcel - The only trocar that affords ...
Medicine Products: