Navigation Links
Drug combination acts against aggressive chronic lymphocytic leukemia
Date:12/10/2012

ATLANTA - A two-prong approach combining ibrutinib and rituximab (Rituxin) to treat aggressive chronic lymphocytic leukemia (CLL) produced profound responses with minor side effects in a Phase 2 clinical trial at the University of Texas MD Anderson Cancer Center.

Researchers presented the results today at the 54th annual meeting of the American Society of Hematology (ASH).

"This is a patient population with a great need for more targeted therapies," said Jan Burger, M.D., Ph.D., associate professor in MD Anderson's Department of Leukemia. Burger was lead author of the study.

"Many CLL patients, especially those with indolent or non-aggressive disease, do well on the standard treatment of chemotherapy and antibodies," he said. "But for a certain subset of high-risk patients, treatment often fails, and remissions, if they are achieved, are short."

According to the National Cancer Institute's Surveillance Epidemiology and End Results database, CLL is the most common type of adult leukemia in the United States. An estimated 16,000 new cases will be diagnosed this year, and about 4,600 people will die because of the disease. Median age of diagnosis is 72, and it is more common in men than women.

Although chemotherapy combinations have improved the cure rate for CLL, side effects often are severe. A sizeable number of CLL deaths are from secondary cancers caused by treatment.

Early studies showed potential

Ibrutinib, a tyrosine kinase inhibitor that thwarts B-cell receptor signaling, is a promising new targeted therapy for mature B-cell malignancies, including certain types of myeloma and lymphoma. It has been shown to be especially effective in CLL.

Over the past two years, Phase 1/2 trials at MD Anderson and other sites showed high-risk CLL patients responded as well as low-risk patients to ibrutinib. However, the response often is lessened because of persistent lymphocytosis, an
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
2. Combination treatment may improve survival of breast cancer patients with brain metastases
3. Drug combination against NRAS-mutant melanoma discovered
4. Combination peptide therapies might offer more effective, less toxic cancer treatment
5. DNDi and Cipla to develop 4-in-1 pediatric antiretroviral drug combination
6. BUSM in vitro study identifies potential combination therapy for breast cancer
7. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
8. Discovery suggests new combination therapy strategy for basal-like breast cancers
9. Cancer vaccine combination therapy shows survival benefit in breast cancer
10. Combination of 2 drugs reverses liver tumors
11. Immunotherapy for elderly cancer patients finds new promise in drug combination
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug combination acts against aggressive chronic lymphocytic leukemia
(Date:11/28/2014)... November 28, 2014 Lice Troopers Lice Removal ... its in-home head lice service for moms in Miami-Dade ... center of Coral Gables on Pone De-leon Blvd in Miami. ... Islands that service Miami-Dade & Broward. Lice Troopers is ... South Florida which has been treating families for several years. ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 "Most of my ... me to use crutches," said an inventor from Findlay, Ohio. ... convenient way to support my foot, which inspired me to ... to offer a convenient way to support an injured foot. ... around. It eliminates the need for crutches. The design redistributes ...
(Date:11/28/2014)... Schools like Centra Rivermont understand the therapeutic and ... to its students. That is why the Virginia ... structure at its mental health services facility in ... for children who are identified as needing additional ... served the needs of children with severe emotional ...
(Date:11/28/2014)... Brentwood, TN (PRWEB) November 28, 2014 ... in Tennessee for the first time. PAI Medical Group ... M.D. will be performing a robotic hair transplant procedure ... at 9:00 A.M. , The first in Tennessee and ... PAI Medical Group now offers ARTAS robotic hair transplantation. ...
(Date:11/28/2014)... Most of the people attending a presentation by Ken Farmer ... Woods retirement community found out the “prized” possessions they ... have made the cut to be on an “Antiques Roadshow” ... and folk art and his appearances on the PBS program ... and selling antiques. Broadly speaking the antiques market is ...
Breaking Medicine News(10 mins):Health News:Lice Troopers Lice Removal Service Expands in Miami-Dade 2Health News:Centra Rivermont (VA) Provides School Playground Equipment from APCPLAY© for Special Needs Students 2Health News:Centra Rivermont (VA) Provides School Playground Equipment from APCPLAY© for Special Needs Students 3Health News:First in Tennessee - PAI Medical Group Announces ARTAS - The World’s Most Advanced Medical Robot Used for Hair Transplant Surgery 2Health News:Antiques Appraiser Sheds Light on "Treasures" 2
... Food and Drug Administration (FDA) and Roxane Labs have ... are used in patients with severe// rheumatoid arthritis as ... ,"It was discovered that a single bottle of ... 2.5 mg. While we believe this issue may be ...
... local newspaper to pay compensation and apologise to a young ... unethical reporting.// ,Beijing Chaoyang District Court ordered the ... (2,500 US dollars) and issue an apology on its front ... carried three photos of the woman and the story of ...
... companies have evinced interest to invest in India ... committing Rs 1,665 crore investment for capacity expansion ... and Fertilisers Minister Ram Vilas Paswan said here. ... to Japan recently, said during his trip significant ...
... is not healthy to lose weight soon after giving birth, ... the pitfalls of following celebrity trends//, and aspiring for an ... serious effects on the health of the mother and the ... the baby’s birth, is a time for building nutrition ...
... Health (MOH) says that Singapore will soon conduct a ... Readiness.// , More than 1,000 personnel from ... of Education, the Civil Aviation Authority of Singapore, Immigration ... in the exercise code-named SPARROWHAWK II. , ...
... lakh equity shares to Ranbaxy Laboratories on a preferential basis ... directors has approved the issue of 20 lakh equity shares ... a preferential basis to Ranbaxy, subject to shareholders' approval, the ... approved the allotment of shares over 1.11 crore equity shares ...
Cached Medicine News:
(Date:11/28/2014)... 28, 2014 Aratana Therapeutics, Inc. (NASDAQ: ... licensing or acquisition, development and commercialization of innovative biopharmaceutical ... announced that it will present at the 26 th ... December 2-3, 2014, at the New York Palace Hotel ... Steven St. Peter , M.D., President and Chief ...
(Date:11/27/2014)... 27, 2014  Javon Bea Mercy Health System ... and staff at Janesville Craig High School and Janesville ... Health System physicians and Janesville ... and the Janesville School District. ... dedicated to providing schools and other organizations with the ...
(Date:11/26/2014)... SAN DIEGO , Nov. 26, 2014  Aethlon ... into a definitive agreement to raise approximately $3.3 million ... is being made by one institutional healthcare focused investor. Each ... one-fifth of a common share purchase warrant. Each whole ... at a price of $0.30 for a period of ...
Breaking Medicine Technology:Aratana Therapeutics to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Mercy Health System, Janesville Police / Fire, provide casualty training to high school faculty 2Mercy Health System, Janesville Police / Fire, provide casualty training to high school faculty 3Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3
... , RALEIGH, N.C., Nov. 24 Pharmaceutical ... pharmaceutical and biotech industry, today announced the launch of a ... Hospital Marketplace e-course is the newest addition to ... series of e-courses designed to fill the critical need for ...
... , SALT ... City based software company, announces the launch of a new online vision ... with existing in-office therapy methods. , eyeQ was introduced at ... Brad Habermehl believes the eyeQ program adds significant value to ...
Cached Medicine Technology:Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 3Infinite Mind Announces the Launch of a New Online Vision Therapy Program eyeQ 2
Stainless steel lockable wall display for up to 12 frames....
... display system provides maximum impact for the ... unique approach to displaying frames allows your ... create appealing, flexible and eye-catching displays. The ... your patients are motivated. Removable holders. Variable ...
Single Eyevee 2.0 Frame Clip. Available in black, clear and silver colors....
... ClinicDB is a multi-page ... that maintains a database of ... microscopy results, adverse reactions, etc. ... reports, letters and invoices that ...
Medicine Products: