Navigation Links
Drug Shields Mice From Emphysema
Date:12/22/2008

Experimental approach seemed to protect the animals from smoke's harmful effects, researchers say

MONDAY, Dec. 22 (HealthDay News) -- In experiments in mice, scientists have shown that a new drug may protect the animals from the respiratory damage caused by cigarettes.

The finding holds out hope for patients with chronic obstructive pulmonary disease (COPD) -- a chronic progressive lung disease involving both emphysema and chronic obstructive bronchitis.

COPD, most commonly linked to smoking, is the fourth leading cause of death in the United States and there are no effective treatments.

"Our previous studies have shown that there is a defect in Nrf2 -- a master regulator of antioxidant and detoxifying pathways -- in the lungs of COPD patients that may be involved in the severity of this disease," explained lead researcher Shyam Biswal, an associate professor at the Johns Hopkins Bloomberg School of Public Health in Baltimore.

In this study, the researchers used a novel drug molecule called CDDO-imidazole (CDDO-Im) to curb the progression of the disease by targeting the Nrf2 pathway.

"The result demonstrates that this strategy is effective in the preclinical model of emphysema," Biswal said.

The report is published in this week's online edition of the Proceedings of the National Academy of Sciences.

For the study, Biswal's team exposed mice to cigarette smoke for six months. Half the mice were treated with CDDO-Im while the other animals were not.

The researchers found that mice treated with CDDO-Im did not develop heart and lung damage while their untreated counterparts did.

Dr. Norman Edelman, chief medical officer of the American Lung Association, believes the new approach to treating COPD could be effective.

"There have been several studies identifying disrupted oxidant defense systems in COPD," Edelman said. "What's different about this one is that a control point for a whole group of oxidant defenses has been identified in rather elegant studies. Thus, if a therapy up-regulating this site were developed it would be more likely to be effective in COPD," he said.

This study provides hope that strategies aimed at targeting the Nrf2 pathway might be effective in inhibiting the development of emphysema, Biswal said.

"Future studies will be done in COPD patients to test the strategy of targeting Nrf2, to test the efficacy in reducing the burden of this debilitating disease," Biswal said.

However, Dr. Bartolome R. Celli, chief of pulmonary care at St. Elizabeth's Medical Center in Boston, said the jury is still out on the effectiveness of this approach.

"It is an interesting and intriguing study," Celli said. "However, from the experiments in mice to reality in humans there usually is a great distance," he said.

There is consensus that oxidative stress associated with cigarette smoking is important in COPD, so balancing oxidative stress with antioxidants makes sense, Celli said.

"This study takes it one step further by testing the hypothesis in vivo [animals]," according to Celli. "Let's wait for the translation into humans," he said.

More information

For more information on emphysema, visit the U.S. National Library of Medicine .



SOURCES: Shyam Biswal, Ph.D., associate professor, Johns Hopkins Bloomberg School of Public Health, Baltimore; Bartolome R. Celli, M.D., chief, pulmonary care, St. Elizabeth's Medical Center, Boston; Norman Edelman, M.D., chief medical officer, American Lung Association; Dec. 22-26, 2008, Proceedings of the National Academy of Sciences, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Football helmet shields can protect against a kick in the face
2. Col. Robert E. Shields Joins Palmetto GBAs Board of Directors
3. Appropriate timing in the use of breast shields in children can further reduce MDCT radiation dose
4. Potential treatment option for severe emphysema under study
5. Young Pop Stars Emphysema Startles Experts
6. Acne Drug Prevents Tissue Damage From Emphysema
7. Henry Ford Hospital to study effectiveness of a new procedure that may help emphysema suffers
8. Researchers at Pulmonary Associates to study airway bypass procedure for severe emphysema
9. New York Methodist Hospital to study airway bypass treatment for emphysema
10. Researchers at Peoria Pulmonary Associates to study airway bypass procedure for emphysema
11. Lung Bypass Could Fight Emphysema
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Shields Mice From Emphysema
(Date:6/26/2017)... ... 26, 2017 , ... KICKICO , a protocol built on Ethereum for ... many catastrophic issues within funding campaigns. KICKICO developers are testing the platform, which will ... the raising of funds through the power of many - has been around for ...
(Date:6/25/2017)... ... June 25, 2017 , ... An increase in wetter weather in ... plants, and along with that; a humdinger of an allergy season. A relief from ... an increase in misery-causing grass and weed pollen. , “Our patients have been ...
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic Trainers’ Society’s ... and Erie Convention Center on June 8-10. The weekend consisted of many ... award and scholarship presentations, and professional networking. , On Friday June 9th, ...
(Date:6/23/2017)... VA (PRWEB) , ... June 23, 2017 , ... ... of what is needed and will ultimately do significant harm to people with ... to everyone. , "While it leaves in place the Affordable Care Act ...
(Date:6/23/2017)... ... 2017 , ... Dr. Ran Y. Rubinstein , a ... offering three new minimally invasive procedures to patients who want a younger and ... Rubinstein is excited to bring microneedling, microneedling facials, and platelet rich plasma (PRP) ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... June 14, 2017 The Bio Supply Management ... City of Fremont and the Biomedical Manufacturing ... industry in California by providing ... networking, and fostering workforce development. The primary focus of ... of start-ups, as well as small and mid-sized biomedical ...
(Date:6/10/2017)... June 9, 2017  Shane K. Burchfield, DPM, is recognized by ... as a Podiatrist in Alabama . ... First Foot Care. He brings over 20 years of experience, as ... and healthcare, to his role. ... PC is pleased to welcome you to his practice," ...
(Date:6/8/2017)... 8, 2017  StatLab Medical Products ("StatLab" ... manufacturer of diagnostic supplies for the anatomic ... & Company LP ("Cressey & Company"), a ... growth-focused investment in the Company. Cressey & ... from selling shareholder, Prairie Capital, L.P., with ...
Breaking Medicine Technology: