Navigation Links
Drug Offers Promising Approach to Improve Outcome for Children with High-risk Leukemia
Date:11/15/2013

ing antibody-based therapies, that target the same AML surface protein, said the study’s senior author Jeffrey Rubnitz, M.D., Ph.D., a member of the St. Jude Department of Oncology.

AML is diagnosed in about 500 children annually and accounts for about 20 percent of childhood leukemia. The disease affects white blood cells.

“Currently there are few options for AML patients who relapse or do not respond to conventional therapy,” said first author Carol O’Hear, M.D., Ph.D., a St. Jude postdoctoral oncology fellow. Added Rubnitz: “Without new agents, it is unlikely we will be able to improve pediatric AML survival beyond current levels of about 70 percent. The results of this and earlier studies make a strong case that some patients benefit from this targeted therapy, which has us looking for new ways to take aim at the same protein.”

This study involved a subset of patients enrolled in a clinical trial of pediatric AML called AML02. Altogether, 232 children with AML enrolled in the six-year, multicenter trial that ended in 2008. A total of 46 patients received GO alone or in combination with conventional chemotherapy.

For this analysis, researchers wanted to know if GO was associated with reduced MRD. Patients were considered free of MRD if less than one cancer cell could be detected in 1,000 normal bone marrow cells.

Seventeen patients received GO alone when MRD was detected after two rounds of chemotherapy with the drugs cytarabine, daunorubicin and etoposide. After GO treatment, leukemia declined in 14 of the 17 patients and fell to undetectable levels in 13 patients.

An additional 29 patients received GO as part of their second round of three-drug chemotherapy. All had levels of residual disease that indicated a poor initial response to chemotherapy alone, including nine with MRD levels of 25 percent or more. Residual disease fell to undetectable levels in four of the nine patients following combination therapy.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Drug offers promising approach to improve outcome for children with high-risk leukemia
2. Absolute Bird Control Offers Complete Line of Woodpecker Deterrents
3. Spectrum Surgical Offers a Range of Surgical Instrument Education Programs and Products for Ongoing Training and to Make Patients Safer
4. Medorizon Offers EMR and ICD-10 Training to Help Medical Community with Change
5. 4leafcity.com Is Launching Special Offers On Its Cardigan Sweaters For Men
6. UC Davis Children's Hospital Offers Access to Pediatric Subspecialty Care for Rural Newborns With PEANUT Program
7. Winter Issue of ChopChop Magazine Offers Edible Gift Ideas for Kids to Make for Family and Friends
8. Asbestos Found in Winnebago County Jail, Florida Asbestos Testing Company AGC Environmental Offers Tip How to Avoid the Mineral Fiber's Fatal Health Effects
9. Goji Advance Weight Loss Formula Offers and Deals: Now Customers Can Get One Extra Bottle on Select Packages
10. Venapro: The Natural Hemorrhoids Treatment Product Now Offers 50% Discount on Select Packages for Limited Time
11. Adventure To Fitness Offers Trial Weekend For Thanksgiving
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Allegheny General Hospital’s (AGH) Cardiovascular ... physicians to repair a damaged mitral valve as the ... system, developed by Abbott Vascular , is designed ... life-threatening condition in which the heart’s mitral valve leaflets ... from the heart’s left ventricle into the left atrium. ...
(Date:10/20/2014)... T.E.N., a technology and information security ... William H. Murray, renowned author and industry visionary, ... Award winner. Presented annually, the ISE® Luminary Leadership ... and industry practitioner for his or her distinguished ... security industry. , Formerly with IBM, Murray is ...
(Date:10/20/2014)... WA (PRWEB) October 20, 2014 My ... workflow management software application. The new module enables ... patients receive full life-cycle quality care. , This application ... others within their practice, attach a to-do item to ... fit, and even set up reoccurring reminders for follow-ups. ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Rockynol ... Living Center on Oct. 14. The $11 million project ... services, and a cooked-to-order kitchen with full-service restaurant style ... premier choice for first class Assisted Living apartments,” said ... residents deserve the highest quality of care and this ...
(Date:10/20/2014)... Aliso Viejo, California (PRWEB) October 20, 2014 ... have announced the release of the Citrus theme for ... words I would use to describe the Citrus theme” Says ... been so easy to look so professional.” , Citrus comes ... . Included with the template are: four transitions for added ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2
... a comprehensive new study of mental health status and the ... for Health Policy Research found that nearly one in five ... said they needed help for a mental or emotional health ... or more than 1 million, reported symptoms associated with serious ...
... likely to use walkers, canes and other mobility devices at ... them incorrectly, according to new research from Purdue University. ... epidemic for this population as well," said Karis Pressler, a ... author. "This research shows that if obesity continues at this ...
... passion fruit pathologist, a catfish breeder, and a pigeon ... scientists from 10 African countries who received a fellowship ... (AWARD). The fellowship will help these top researchers strengthen ... to poverty alleviation and food security across the continent. ...
... 2010) Errors in diagnosis place a heavy financial ... can be devastating for affected patients. Strengthening certain ... and coordinated primary care could potentially address this highly ... Baylor College of Medicine ( www.bcm.edu ) and Stony ...
... results in 2 million injuries among women in the ... and Human Services. University of Missouri researchers are reducing ... women experiencing abuse develop individualized safety plans and better ... current Internet resources, the decision-aid program provides women with ...
... News) -- Weight-loss surgery, also known as bariatric surgery, ... of serious complications, a new study suggests. The ... that do the highest number of bariatric surgeries, according to ... Journal of the American Medical Association . Rates ...
Cached Medicine News:Health News:Nearly 1 in 5 Californians report need for mental health services, study finds 2Health News:Study: Weight issues move up need for walkers, canes, other devices 2Health News:Study: Weight issues move up need for walkers, canes, other devices 3Health News:AWARD Fellowship highlights critical role of African women in agricultural research 2Health News:AWARD Fellowship highlights critical role of African women in agricultural research 3Health News:Reform of primary care could reduce diagnostic errors 2Health News:Reform of primary care could reduce diagnostic errors 3Health News:Reform of primary care could reduce diagnostic errors 4Health News:Use of decision-aid program increases safety for women experiencing abuse, researchers find 2Health News:Complications From Weight-Loss Surgery 'Relatively Low' 2
(Date:10/19/2014)... 19, 2014  Henry Schein, Inc. (NASDAQ: ... products and services to office-based dental, animal health and ... Iwase Dental Supply, Inc., a leading full-service provider of ... Henry Schein,s entrance into Japan , ... increases to 28 the number of countries in which ...
(Date:10/17/2014)... Oct. 17, 2014  Training market researchers to ... success factor in today,s highly competitive global marketplace. ... organizations that effectively and efficiently produce high performing ... area. Effective training programs can ... recognition from internal clients by developing analysts who ...
(Date:10/17/2014)... DUBLIN , October 17, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/7jx6nq/china ) has announced the addition ... Report,2014-2017"  report to their offering.  ... of cardiovascular disease in China ... population and changes in consumption concept, dietary ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3
... 03, 2007 /PRNewswire/ -- Bayer HealthCare,Pharmaceuticals announced ... Betaseron(R) (interferon beta-1b), presented this week,at the ... Meeting,demonstrating early efficacy, long-term tolerability, and high,patient ... of multiple sclerosis (MS). , "Collectively, these ...
... EDMONTON, May 02, 2007 /PRNewswire-FirstCall/ - Quest PharmaTech,Inc. ... provide an,update on the pre-clinical development of SL052 ... is the second leading cause of cancer death ... 30,000 deaths,per year. Current therapeutic modalities for localized ...
Cached Medicine Technology:Studies Presented at Neurology Conference Highlight Early Efficacy,Long-Term Tolerability, and High Patient Satisfaction with,Betaseron 2Studies Presented at Neurology Conference Highlight Early Efficacy,Long-Term Tolerability, and High Patient Satisfaction with,Betaseron 3Studies Presented at Neurology Conference Highlight Early Efficacy,Long-Term Tolerability, and High Patient Satisfaction with,Betaseron 4Quest PharmaTech's Prostate Cancer Program Update 2Quest PharmaTech's Prostate Cancer Program Update 3
Coronary angiographic catheter...
... Merit has a complete offering of cardiology ... brands, these catheters are designed with excellent ... strength and better push-ability, and large inner ... 4, 5, 6 and 7 French sizes ...
The CRW system epitomizes simplicity, quality assurance, and versatility....
Hydrosteer wires are intended for use in the percutaneous introduction of catheters....
Medicine Products: