Navigation Links
Drug Offers Promising Approach to Improve Outcome for Children with High-risk Leukemia
Date:11/15/2013

Memphis, Tenn. (PRWEB) November 15, 2013

Combining the drug gemtuzumab ozogamicin (GO) with conventional chemotherapy may improve the outcome of bone marrow transplantation for some children battling high-risk acute myeloid leukemia (AML), according to a study led by St. Jude Children’s Research Hospital. The results appear in the current edition of the journal Cancer.

For young AML patients with suitable bone marrow donors, transplantation offers the best chance of a cure. Being free of even low levels of detectable cancer cells prior to transplantation is associated with better patient survival. This analysis found that combination therapy helped to eliminate minimal residual disease (MRD) in young AML patients who initially had a poor response to chemotherapy. By reducing MRD levels prior to transplantation, it is likely that GO contributed to the excellent outcome of these patients, researchers said.

The drug, trade named Mylotarg, received accelerated approval from the U.S. Food and Drug Administration in 2000 for treatment of AML in adults. The drug was voluntarily withdrawn in 2010 following questions about its safety and efficacy. Since then several studies conducted while the drug was authorized reported promising results in adults with AML. Those reports prompted this analysis of pediatric AML patients who received GO in a clinical trial conducted while the drug was available.

Researchers said the results add to evidence that both adults and children battling AML may benefit from treatments that use a similar mechanism as GO to combat AML. The drug was not associated with severe toxicity in this or other recent studies.

Unlike traditional chemotherapy that kills rapidly dividing cells, both malignant and healthy, GO was designed to kill more selectively. The drug works by targeting a protein carried on the surface of about 90 percent of AML cells. Work has begun on new strategies, includ
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Drug offers promising approach to improve outcome for children with high-risk leukemia
2. Absolute Bird Control Offers Complete Line of Woodpecker Deterrents
3. Spectrum Surgical Offers a Range of Surgical Instrument Education Programs and Products for Ongoing Training and to Make Patients Safer
4. Medorizon Offers EMR and ICD-10 Training to Help Medical Community with Change
5. 4leafcity.com Is Launching Special Offers On Its Cardigan Sweaters For Men
6. UC Davis Children's Hospital Offers Access to Pediatric Subspecialty Care for Rural Newborns With PEANUT Program
7. Winter Issue of ChopChop Magazine Offers Edible Gift Ideas for Kids to Make for Family and Friends
8. Asbestos Found in Winnebago County Jail, Florida Asbestos Testing Company AGC Environmental Offers Tip How to Avoid the Mineral Fiber's Fatal Health Effects
9. Goji Advance Weight Loss Formula Offers and Deals: Now Customers Can Get One Extra Bottle on Select Packages
10. Venapro: The Natural Hemorrhoids Treatment Product Now Offers 50% Discount on Select Packages for Limited Time
11. Adventure To Fitness Offers Trial Weekend For Thanksgiving
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... risk of death and heart attack can be reduced for ... the usual dose of an anti-clotting drug before the procedure ... a balloon-tipped catheter is threaded into an artery. The balloon ... the vessel. A small synthetic tube - stent is used ...
... It has been found out that there is no association ... food -- and breast cancer. More than 43,000 women were ... participants had their average daily intake of acrylamide monitored. No ... women whose intake was higher was documented. Acrylamide was first ...
... Session of the International Association for Dental Research held ... of a study// that says eating sugar-free yogurt is ... bad odor or so called bad breath is caused ... The study revealed that volunteers who had sugar-free more ...
... has found out that depression has to be blamed for ... to treat the same. The study was conducted on 60,000 ... results showed both the newer and older classes of antidepressants ... first month of being prescribed.The older class of tricyclic antidepressants ...
... of the drug tezosentan did not improve worsening heart failure ... despite high hopes. The above fact was found out in ... The study was conducted to evaluate if something more could ... speed up hospital discharge and prevent them from coming back. ...
... known to help in controlling obesity. A new study coming ... (2005) says that dietary calcium present in the yogurt has ... lipid utilization and decrease in lipogenesis. ,The ... group was put on balanced deficit diets and the other ...
Cached Medicine News:
(Date:12/24/2014)... , December 24, 2014 ... Report on Global Disposable Syringe Industry of ... its online business intelligence library. ... Disposable Syringe Industry is a professional and ... market.  For overview analysis, the report introduces ...
(Date:12/24/2014)... ALEXANDRIA, Va. , Dec. 23, 2014 /PRNewswire-USNewswire/ ... stringent diastolic blood pressure target for people with ... either moderate or high doses of statins, in ... risk management enacted by the American College of ... recommendations are reflected in the most recent changes ...
(Date:12/24/2014)... HILL, N.C. , Dec. 23, 2014  Medical ... success. As the key link between the medical device ... grow even more in the coming years as the ... According to research by benchmarking firm, ... MSLs can gain an important edge is by harnessing ...
Breaking Medicine Technology:World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... CorMatrix® Cardiovascular, a medical device company dedicated to developing ... body,s innate ability to repair damaged cardiovascular tissue, announced today it ... Repair. With this designation, CorMatrix is now able to market this ... , , ...
... Company (Nasdaq: PRGO;TASE) today announced that Perrigo Executive Vice President and CFO ... Global Healthcare Conference on Tuesday, June 15 , at 3:05 ... Los Angeles .  The presentation will be webcast on the following link: ... , Perrigo ...
Cached Medicine Technology:CorMatrix(R) ECM(TM) Receives CE Mark for Cardiac Tissue Repair 2
... Ankle/Brachial Index (ABI) testing, Nicolet Vascular has ... It includes a 10-minute compact disk ABI ... any computer with a CD drive. It ... ABI test, provides information on the materials ...
... Triad Skull Clamp, compatible with the full ... of clamping force on all three skull ... the possibility of adjusting the force on ... be increased or decreased by adjusting the ...
... Advanced engineering, rapid acquisition of data, ... it the most accurate autorefractor available. ... High Quality Monitor allows for easy ... are taken as soon as focus ...
... Clinitek Microalbumin Strips provide albumin, creatinine and ... Clinitek Microalbumin product is useful to test ... hypertension in order to detect early kidney ... of the urinary albumin excretion rate, is ...
Medicine Products: