Navigation Links
Drug May Help Against Inflammatory Breast Cancer
Date:4/27/2009

Study shows those who respond to lapatinib survive longer,,,,

MONDAY, April 27 (HealthDay News) -- The drug lapatinib could be used to treat aggressive inflammatory breast cancer, suggest the findings of a phase 2 study.

Inflammatory breast cancer accounts for up to 6 percent of all invasive breast tumors in the United States and western Europe, according to the researchers. Symptoms include rapid onset of swelling, redness of breast skin, a pitted appearance caused by fluid under the skin of more than two-thirds of the breast, tenderness, hardening and warming of the breast.

For patients resistant to conventional anthracycline or taxane and trastuzumab, treatment options are limited. Lapatinib inhibits HER2, a protein that's expressed much more in inflammatory breast cancer than in other, less aggressive breast cancers.

The study included 126 women who took 1,500 milligrams of lapatinib once a day. None of them showed a full response to the drug, but 39 percent had a partial response, the researchers reported. Median progression-free survival was 15 weeks and, at 6 months, 22 percent of the women were still progression-free.

When the researchers divided the participants into four groups, they found that median overall survival was:

  • 18.4 months for those who responded to lapatinib after previous treatment with trastuzumab
  • 14 months for those who responded to lapatinib and had no previous trastuzumab treatment
  • 8.4 months for those unresponsive to lapatinib who had previously taken trastuzumab
  • 8.2 months for those unresponsive to lapatinib who had not previously taken trastuzumab.

The study found that 92 percent of the women had at least one adverse event, including shortness of breath and fluid around the lungs. Five participants died from adverse events that were possibly treatment related, said the Israeli and U.K. researchers.

"Pa
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
3. Despite overeating, morbidly obese mice gain protection against diabetes
4. Alvarado Hospital Files Countersuit Against Blue Shield
5. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
6. Claim Filed Against the Company and Nine Other Defendants in the Haifa Magistrates Court
7. First Circuit Court of Appeals Rules Against Philip Morris in Lights Class Action
8. $52.5 Million Settlement Against Sepracor Inc. Approved
9. The fight against colorectal cancer
10. Especially Yours and Paula Young Team up with Diahann Carroll and Jaclyn Smith in the Fight Against Breast Cancer
11. Breastfeeding does not protect against asthma, allergies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug May Help Against Inflammatory Breast Cancer
(Date:9/21/2014)... 2014 (HealthDay News) -- Young women starting college understand ... foods they should eat. But they aren,t confident they ... to a new study. The study involved ... Illinois,s Peer Education Exercising and Eating Right program. The ... choose to eat if they were very busy with ...
(Date:9/21/2014)... September 21, 2014 Discount-Dress.com, ... accessories, has recently announced its decision to implement a ... shopping easier for ladies across the world. Furthermore, the ... dresses for ladies. , The new items come ... with discounted prices, up to 56 percent off. "We ...
(Date:9/21/2014)... 21, 2014 Market Research ... 49562-28-9) Industry, 2009-2019 is a professional and ... Fenofibrate (CAS 49562-28-9) industry. The report firstly ... 49562-28-9) including its classification, application and manufacturing ... top manufacturers of Fenofibrate (CAS 49562-28-9) listing ...
(Date:9/21/2014)... High in the rugged Gore Range ... able-bodied athletes rafted the Colorado River, rode mountain bikes ... pursuit of outdoor adventure. At the September 12-14 ... Sports, disabilities proved to be no more than an ... stage event. , Each participating team of five athletes ...
(Date:9/21/2014)... An experienced review website in the global market, Top10BestSEOHosting.com, ... announced that FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ), GoDaddy and Bluehost ... has been a boom in websites in recent years, ... in the number of web hosting companies that offer ... VPS (Virtual Private Server) is the method of partitioning ...
Breaking Medicine News(10 mins):Health News: College Women Can Use Food Strategies, Study Finds 2Health News:Discount-Dress.com Implements A New Shopping Cart Software And Provides New Beach Wedding Dresses 2Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 2Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 3Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 4Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 2Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 3Health News:Top10BestSEOHosting.com: FatCow, GoDaddy And Bluehost Are The Best VPS Hosting Suppliers 2
... in four teenagers who had meningitis during infancy will not ... in Archives of Disease in Childhood. ,The findings ... year olds across England and Wales, 461 of whom had ... ,The children were all taking part in a long ...
... Scientists of University College London have conducted a study ... is indeed responsible// for dyscalculia or in ... hope the findings will aid in the diagnosis and ... ,Dyscalculia is just as prevalent in the population as ...
... the Victorian disease tuberculosis is on the march. Figures released by ... percent in number of TB cases over the last year. ... on the 24th of March, are provisional and relate ... account for the highest proportion of cases (42 percent) but the ...
... Steriani Elavsky, women passing through their menopause are reported to ... improvements in heart and respiratory fitness are said to have ... ,This research was carried out on 164 inactive menopausal ... basis. One group was assigned to perform Yoga while the ...
... junior doctors' has been reduced in order to increase their ... medics found that cutting down working hours alone is not ... of rotas was essential. ,The Occupational and Environmental ... Auckland universities in New Zealand. ,In the UK, ...
... that the odds of firefighters dying from coronary heart disease ... 100 times higher than during non-emergency duties such as rescuing ... Harvard Medical School and colleagues say episodic physical and psychological ... of physical fitness appeared responsible for it. ,Even though ...
Cached Medicine News:Health News:Reason Behind Dyscalculia Revealed 2Health News:TB Cases on the Rise 2Health News:Rest for Doctors to Ensure Patients’ Safet 2Health News:New Study Reveals That Firefighters Are Prone To Heart Attack 2
(Date:9/19/2014)... SOUTH EASTON, Mass. , Sept. 19, 2014 ... the "Company") today announced it has received and ... throughput Barozyme HT48 instruments and has begun to ... believes the first instrument will be ready for ... will be built and released at a rate ...
(Date:9/19/2014)... , Sept. 19, 2014  The body of ... the publication of two papers this past week.  The ... Head and Neck Surgery , finds that withholding ... subjective measures of sleep disordered breathing, leading the paper,s ... in obstructive sleep apnea severity and improvement of quality ...
(Date:9/19/2014)... VIENNA , Sept. 19, 2014 ... positive interim clinical data for its lead candidate ITCA ... diabetes patients with high baseline HbA1c levels at the ... for the Study of Diabetes (EASD). Data from the ... reduced levels of blood sugar in patients with poorly ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4
... 2012  Legal-Bay, announced today that their applications for Transvaginal ... sharply since the company began funding plaintiffs for Mesh ... the legal funding industry do not fund Vaginal Mesh ... industry leader who is one of the few companies ...
... NORTHRIDGE, Calif., April 2, 2012 No matter the advances ... Americans are suffering with tooth damage and decay every single ... 25 percent of all adults as well as 16 percent ... restore the integrity and appearance of smiles, the most trusted ...
Cached Medicine Technology:Vaginal Mesh and Kugel Hernia Mesh Case Applications for Lawsuit Funding on the Rise at Legal-Bay Settlement Funding 2Northridge Cosmetic Dentists, Dr. Michel Elyson and Dr. Ramin Assili, are Now Offering Advanced Tooth Colored Restorations to Restore Smiles 2
... The D.O.R.C. Associate® is an ... a Peristaltic and Venturi pump, allowing ... mode for Phaco or Vitrectomy procedures.,The ... is a microprocessor-controlled vacuum system that ...
The D.O.R.C. CryoStar is the smart cryosurgical system that combines optimal performance with state-of-the-art automation. simple for O.R. staff to operate and maintain throughout every procedure....
The D.O.R.C. Silicone Oil is an ultra purified silicone oil which leads a maximum interfacial tension and minimizes interactions between tissues, cells and endo-tamponades media. (Sterile, 10 ml.)...
The D.O.R.C. Silicone Oil is an ultra purified silicone oil which leads a maximum interfacial tension and minimizes interactions between tissues, cells and endo-tamponades media.(Sterile, 10 ml.)...
Medicine Products: