Navigation Links
Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
Date:12/1/2011

WEDNESDAY, Nov. 30 (HealthDay News) -- Preliminary research suggests that a drug typically used to kickstart the immune system may help cancer patients who receive stem cell transplants and then develop a potentially deadly side effect.

The drug appears to work by preventing the donor's immune system cells from overreacting to their new home and causing systemic inflammation.

Researchers found that daily low-dose injections of interleukin-2 appeared to help some patients by treating the side effect, known as graft-versus-host disease (GVHD).

Stem cell transplants can treat blood cancers such as leukemia. "More than half of patients who successfully undergo hematopoietic stem cell transplants [in which the blood-making tissue in the bone marrow is wiped out with chemotherapy and replaced with blood-forming stem cells from a donor] develop chronic GVHD," study author Dr. John Koreth, of Dana-Farber Cancer Institute in Boston, said in an institute news release. "The conventional treatment, glucocorticoids, are limited in their effectiveness and can produce significant side effects."

GVHD is "a big problem," said Dr. Gary Schiller, director of the Hematological Malignancies/Stem Cell Transplantation Unit at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles. Schiller was not involved with the study.

In the study, 12 of 23 patients who took the drug for eight weeks showed improvement in symptoms related to GVHD, including skin rash and other skin problems, hepatitis and inflamed lungs. The condition didn't worsen while the patients took the drug.

The study is the first phase of three stages of research that drug treatments must undergo before the federal government approves them to treat specific conditions. That means the findings are preliminary and may not be replicated in future research.

Schiller said the findings make sense. However, the treatment "has no impact, to my knowledge, on curing cancer. It only has an impact on decreasing the complications of the cancer cure."

The study, published in the Dec. 1 issue of the New England Journal of Medicine, was funded by several research grants and awards.

More information

For more about stem cells, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Gary Schiller, M.D., director, Hematological Malignancies/Stem Cell Transplantation Unit, Jonsson Comprehensive Cancer Center, University of California, Los Angeles; Dec. 1, 2011, New England Journal of Medicine; Dana-Farber Cancer Institute, news release, Nov. 30, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gastric Bypass May Dampen Desire for High-Fat Foods
2. Patent awarded for method to dampen immune response
3. Surgery May Boost Survival With Dangerous Heart Condition
4. Tests to catch the makers of dangerous legal high designer drugs
5. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
6. Experts Point Out Signs of Dangerous Heart Rhythm
7. Diverticulitis Surgery More Dangerous for Older Black Patients: Study
8. Trauma experts criticize BBCs Holby City for peddling dangerous drugs
9. Dangerous Bacteria Hide Out in Nurses, Doctors Uniforms
10. Mobile Devices Dangerous for Pedestrians, Too
11. Antidepressant Tied to Dangerous Heart Rhythm: FDA
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
(Date:6/27/2016)... ... June 27, 2016 , ... ... strategic partnership with Connance, a healthcare industry leader providing predictive analytics to ... technology combine to provide health systems, hospitals and ambulatory surgical centers with ...
(Date:6/27/2016)... KS (PRWEB) , ... June 27, 2016 , ... TopConsumerReviews.com ... retailers of Eyeglasses . , Millions of individuals in the United States and ... have become a way to both correct vision and make a fashion statement. Even ...
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
Breaking Medicine Technology: