Navigation Links
Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
Date:12/1/2011

WEDNESDAY, Nov. 30 (HealthDay News) -- Preliminary research suggests that a drug typically used to kickstart the immune system may help cancer patients who receive stem cell transplants and then develop a potentially deadly side effect.

The drug appears to work by preventing the donor's immune system cells from overreacting to their new home and causing systemic inflammation.

Researchers found that daily low-dose injections of interleukin-2 appeared to help some patients by treating the side effect, known as graft-versus-host disease (GVHD).

Stem cell transplants can treat blood cancers such as leukemia. "More than half of patients who successfully undergo hematopoietic stem cell transplants [in which the blood-making tissue in the bone marrow is wiped out with chemotherapy and replaced with blood-forming stem cells from a donor] develop chronic GVHD," study author Dr. John Koreth, of Dana-Farber Cancer Institute in Boston, said in an institute news release. "The conventional treatment, glucocorticoids, are limited in their effectiveness and can produce significant side effects."

GVHD is "a big problem," said Dr. Gary Schiller, director of the Hematological Malignancies/Stem Cell Transplantation Unit at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles. Schiller was not involved with the study.

In the study, 12 of 23 patients who took the drug for eight weeks showed improvement in symptoms related to GVHD, including skin rash and other skin problems, hepatitis and inflamed lungs. The condition didn't worsen while the patients took the drug.

The study is the first phase of three stages of research that drug treatments must undergo before the federal government approves them to treat specific conditions. That means the findings are preliminary and may not be replicated in future research.

Schiller said the findings make sense. However, the treatment "has no impact, to my knowledge, on curing cancer. It only has an impact on decreasing the complications of the cancer cure."

The study, published in the Dec. 1 issue of the New England Journal of Medicine, was funded by several research grants and awards.

More information

For more about stem cells, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Gary Schiller, M.D., director, Hematological Malignancies/Stem Cell Transplantation Unit, Jonsson Comprehensive Cancer Center, University of California, Los Angeles; Dec. 1, 2011, New England Journal of Medicine; Dana-Farber Cancer Institute, news release, Nov. 30, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gastric Bypass May Dampen Desire for High-Fat Foods
2. Patent awarded for method to dampen immune response
3. Surgery May Boost Survival With Dangerous Heart Condition
4. Tests to catch the makers of dangerous legal high designer drugs
5. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
6. Experts Point Out Signs of Dangerous Heart Rhythm
7. Diverticulitis Surgery More Dangerous for Older Black Patients: Study
8. Trauma experts criticize BBCs Holby City for peddling dangerous drugs
9. Dangerous Bacteria Hide Out in Nurses, Doctors Uniforms
10. Mobile Devices Dangerous for Pedestrians, Too
11. Antidepressant Tied to Dangerous Heart Rhythm: FDA
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
(Date:9/22/2017)... ... , ... On Sunday, September 24, hundreds will gather at Flo Jo Park ... the fastest woman of all time. Flo Jo passed away from complications related ... National Anthem. Mary was a contestant on the 2012 season of America’s Got ...
(Date:9/22/2017)... ... September 22, 2017 , ... Fenwick Agency of Plano, TX has announced the ... part of the nationally recognized ‘Agents of Change’ movement. The agency pledges to select ... leaders to seek out those who most need help. Their hope is to bring ...
(Date:9/22/2017)... ... September 22, 2017 , ... After ... a senior finds a new lease on life with assistance from CreditAssociates. CreditAssociates ... resolve their problem with unsecured debt. The senior is one of the satisfied ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... SABRE Safe Is Smart Scholarship Sweepstakes.,  , Molli C., a graduate student from ... in Educational Leadership and Administration at St. Thomas University in Miami, Florida, was ...
(Date:9/22/2017)... IL (PRWEB) , ... September 22, 2017 , ... Pullano ... attorney Richard L. Pullano has been selected to serve as President of ... 50th President at the Installation and Award Dinner hosted by the NSBA at the ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 6, 2017 Eli Lilly and Company (NYSE: ... new data for galcanezumab and lasmiditan, two investigational treatments ... Headache Society (IHC) taking place Sept. 7-10 in ... highlight new, long-term data from an open-label study evaluating ... (120 mg and 240 mg) for the prevention of ...
(Date:9/5/2017)... , Sept. 5, 2017  Just 18 months ... Insight is pleased to announce the appointment of three ... Tammy Wynne , Dominic Jones-Phillips and ... industry. Tammy ... team of market access writers. She has over ten ...
(Date:9/1/2017)... , Sept. 1, 2017  Bayer will present the latest ... Society for Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... include new preclinical and clinical data on Bayer,s marketed portfolio ... pipeline projects. "We ... minds in cancer research at ESMO," said Carsten Brunn ...
Breaking Medicine Technology: