Navigation Links
Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
Date:12/1/2011

WEDNESDAY, Nov. 30 (HealthDay News) -- Preliminary research suggests that a drug typically used to kickstart the immune system may help cancer patients who receive stem cell transplants and then develop a potentially deadly side effect.

The drug appears to work by preventing the donor's immune system cells from overreacting to their new home and causing systemic inflammation.

Researchers found that daily low-dose injections of interleukin-2 appeared to help some patients by treating the side effect, known as graft-versus-host disease (GVHD).

Stem cell transplants can treat blood cancers such as leukemia. "More than half of patients who successfully undergo hematopoietic stem cell transplants [in which the blood-making tissue in the bone marrow is wiped out with chemotherapy and replaced with blood-forming stem cells from a donor] develop chronic GVHD," study author Dr. John Koreth, of Dana-Farber Cancer Institute in Boston, said in an institute news release. "The conventional treatment, glucocorticoids, are limited in their effectiveness and can produce significant side effects."

GVHD is "a big problem," said Dr. Gary Schiller, director of the Hematological Malignancies/Stem Cell Transplantation Unit at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles. Schiller was not involved with the study.

In the study, 12 of 23 patients who took the drug for eight weeks showed improvement in symptoms related to GVHD, including skin rash and other skin problems, hepatitis and inflamed lungs. The condition didn't worsen while the patients took the drug.

The study is the first phase of three stages of research that drug treatments must undergo before the federal government approves them to treat specific conditions. That means the findings are preliminary and may not be replicated in future research.

Schiller said the findings make sense. However, the treatment "has no impact, to my knowledge, on curing cancer. It only has an impact on decreasing the complications of the cancer cure."

The study, published in the Dec. 1 issue of the New England Journal of Medicine, was funded by several research grants and awards.

More information

For more about stem cells, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Gary Schiller, M.D., director, Hematological Malignancies/Stem Cell Transplantation Unit, Jonsson Comprehensive Cancer Center, University of California, Los Angeles; Dec. 1, 2011, New England Journal of Medicine; Dana-Farber Cancer Institute, news release, Nov. 30, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gastric Bypass May Dampen Desire for High-Fat Foods
2. Patent awarded for method to dampen immune response
3. Surgery May Boost Survival With Dangerous Heart Condition
4. Tests to catch the makers of dangerous legal high designer drugs
5. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
6. Experts Point Out Signs of Dangerous Heart Rhythm
7. Diverticulitis Surgery More Dangerous for Older Black Patients: Study
8. Trauma experts criticize BBCs Holby City for peddling dangerous drugs
9. Dangerous Bacteria Hide Out in Nurses, Doctors Uniforms
10. Mobile Devices Dangerous for Pedestrians, Too
11. Antidepressant Tied to Dangerous Heart Rhythm: FDA
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 26, 2016 Story Highlights: ... models within the health care industry is causing providers ... , Deloitte offers a suite of solutions for ... impacting efficient cost optimization: labor resource analysis, revenue cycle ... facilitate better outcomes and better economics ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
Breaking Medicine Technology: