Navigation Links
Drug May Cut Tremors Associated With Parkinson's
Date:6/2/2008

But relief not on way, since FDA has said evidence of drug's effectiveness lacking

MONDAY, June 2 (HealthDay News) -- A new drug may help people with Parkinson's disease combat the tics, spasms and tremors they experience when their main medications wear off, a new study suggests.

Istradfeylline works by helping nerve and brain signals bypass the damaged dopamine system in the brain that leads to Parkinson's. A study of 395 Parkinson's patients on levodopa, a popular Parkinson's drug, found those using istradefylline experienced 24 percent less "off" time, defined as when the physical symptoms appear after levodopa wears off. A group of those studied who took a placebo showed a 10 percent decrease in "off" time.

"These results suggest that istradefylline is effective as an add-on therapy to other drugs that treat symptoms of Parkinson's disease. More importantly, this medication seems to improve 'off' time in a population in which more than 90 percent of patients are already being treated with two or more drugs," study author Dr. Mark Stacy, of Duke University Medical Center in Durham, N.C., said in a prepared statement.

The findings, published in the June 3 issue of Neurology, may not mean relief is coming soon for Parkinson's sufferers, at least in the United States. In March, the U.S. Food and Drug Administration refused to approve the drug, calling evidence of its effectiveness insufficient. The drug's manufacturer, Kyowa Pharmaceuticals Inc., has suspended development of istradefylline in North America.

The study was supported by Kyowa Pharmaceutical.

Istradefylline is a novel drug approach to Parkinson's. The disease is usually treated with medications that work on dopamine, but their effectiveness wears off after time. Istradefylline appears to connect with receptors other than dopamine to open communication with the brain.

"Istradefylline and other agents in the same class that work in a different area of the brain are an important step forward when treating patients who experience this wearing off phenomenon and side effects related to dopaminergic drugs," Stacy said.

More information

We Move has more about Parkinson's disease.



-- Kevin McKeever



SOURCE: American Academy of Neurology, news release, June 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New study shows promise in reducing surgical risks associated with surgical bleeding
2. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Increased distance to physician associated with thicker skin cancer at diagnosis
5. Minorities more likely to have sleep durations associated with increased mortality
6. Income inequality associated with overnourishment and undernourishment in India
7. Maternal depression and controlling behavior associated with increased stress response in infants
8. Nurses describe dedication, frustration associated with their jobs
9. New research shows ACTOS is associated with a 38 percent lower risk of heart attack
10. New research shows ACTOS is associated with a 38 percent lower risk of heart attack
11. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... FL (PRWEB) , ... February 22, 2017 , ... Gevir, ... from deer antler velvet, announced its products are coming soon to Amazon.com, the world’s ... and Shelley Thomson as a means to develop an effective natural treatment for Shelley’s ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... its certification exam and eligibility requirements effective with the April 2017 testing period. ... 1995. , “The Care Manager Certified (CMC) exam is periodically re-calibrated to ...
(Date:2/22/2017)... ... February 22, 2017 , ... In a 2012 survey, over ... not filling a prescription because they could not afford to pay for it. ... were 30-60%*. At the same time, hospitals, pharmacies, manufacturers and nursing ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... absorption cannabidiol (CBD) serum, “NANOCALM 300” Microemulsified Hemp Extract. This premier nanoemulsified ... from the mouth into the bloodstream. Far outpacing the absorption speed ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... a contract to Quality Insights to help small practices in Delaware, New Jersey, ... Program, established by the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Feb. 22, 2017  Allergan plc (NYSE: AGN), ... be a Gold sponsor of the Alzheimer,s Foundation ... Tour." This tour commemorates AFA,s15 years of educating ... and programs. The tour will include AFA,s free ... and displays of the AFA Quilt to Remember. ...
(Date:2/22/2017)... Oncternal Therapeutics, Inc., a clinical-stage biotechnology ... common malignancies, today announced the closing of an ... to use the proceeds to further clinical development ... preclinical development of a new ROR1-targeted antibody-drug conjugate ... anti-ROR1 monoclonal antibody being developed to treat patients ...
(Date:2/22/2017)... NEW YORK , February 22, 2017 ... half of the 50 states in the U.S. have now legalized ... Brazil , Canada , ... , Portugal , Uruguay ... steps to legalize or decriminalize cannabis in the last two years. ...
Breaking Medicine Technology: