Navigation Links
Drug May Be Dangerous for Kids With Graves' Disease
Date:4/17/2009

Medication known as PTU can cause liver disease, experts say

FRIDAY, April 17 (HealthDay News) -- A recommendation to restrict the use of the antithyroid drug (PTU) in children has been endorsed by the Endocrine Society.

In a letter to the editor in the April 9 New England Journal of Medicine, two experts wrote that PTU can cause severe liver disease in children and should no longer be used as a first-line treatment for children with Graves' disease, a disorder in which the thyroid gland produces more thyroid hormone than the body needs.

Liver damage has not been seen in children treated with the other thionamide derivative, methimazole, noted Dr. Scott A. Rivkees, of Yale University Medical School, and Dr. Donald R. Mattison, of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

The Endocrine Society said this week that it supports the recommendation.

"Despite the relative rarity of Graves' disease in the young, children and adolescents account for as many as 13 of 42 cases of serious PTU-related liver failure reported to date in the medical literature and a similar disproportionate number (4 of 13) of those requiring liver transplant for this indication between 1990-2002," the society said in a news release.

An estimated 40,000 children are treated for Graves' disease each year in the United States. If 40 percent of those children are treated with PTU, then as many as one to two of those children could develop severe liver disease that could lead to a liver transplant or death.

"Even one excess death is too many if it can be prevented," the society said. It suggested that until more study was done, methimazole ought to be considered the preferred treatment for children.

More information

The U.S. National Endocrine and Metabolic Diseases Information Service has more on Graves' disease.



-- Robert Preidt



SOURCE: The Endocrine Society, news release, April 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Grapefruit-Heavy Diet Helped Spur Dangerous Clot
2. Americans United for Life Condemns Ruling Increasing Minors Access to Dangerous Plan B
3. Research Finds Popular Household Pets Transmit Dangerous Parasites to Humans
4. Obesity linked to dangerous sleep apnea in truck drivers
5. Study finds cannabis use, dangerous driving behaviors interrelated
6. Supreme Court Ruling is a Victory for Consumers Injured by Dangerous Drugs, Says Hissey Kientz, LLP
7. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
8. Arab-American women need supplement to boost dangerously low vitamin D levels
9. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
10. Cell phones dangerous for child pedestrians, UAB study finds
11. X-Tremely Dangerous Sports
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug May Be Dangerous for Kids With Graves' Disease
(Date:12/7/2016)... OAK BROOK, Ill. (PRWEB) , ... December 07, 2016 , ... ... linked to early-stage brain damage, according to a study appearing online in the journal ... the incidence is expected to increase significantly due to the rapidly aging population. Damage ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... financial consultation services to residents in the Sacramento/Folsom region, is initiating a charity ... facility. , The Another Choice Another Chance treatment center in Sacramento works to ...
(Date:12/7/2016)... AUSTIN, TX (PRWEB) , ... OCTOBER XX, 2016 ... ... may help solve another mystery. A new study entitled “Canine Filamentous Dermatitis ... Morgellons disease can occur in dogs. The study was published in the prestigious ...
(Date:12/7/2016)... ... 07, 2016 , ... Texas Premier Locksmith , a ... by unethical locksmith companies and is urging Search Engines to improve verification methods ... Premier Locksmith, these fraudulent locksmith services take advantage of consumers locked out of ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... WellnessPro Plus for consumers and healthcare professionals to manage chronic and acute ... the treatment modalities available in a single device. The announcement is part ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... -- Global Hospital Linen Supply and Management Services Market: ... supply and management services market presents a comprehensive analysis ... regional level. The study provides historic data of 2015 ... 2024 based on revenue (US$ Bn). The drivers and ... their impact on demand during the forecast period have ...
(Date:12/7/2016)... Dec. 7, 2016  Palatin Technologies, Inc. ("Palatin") ... on a previously disclosed underwritten public offering of ... acted as sole book-running manager, Roth Capital Partners ... acted as co-manager for the offering. ... in net proceeds, allowing us to continue advancing ...
(Date:12/7/2016)... 2016  Northwest Biotherapeutics (Nasdaq: NWBO ... company developing DCVax® personalized immune therapies for solid ... has not accepted the Company,s plan of remediation ... and the Company has notified Nasdaq of its ... from listing on Nasdaq.  Upon withdrawal from Nasdaq, ...
Breaking Medicine Technology: