Navigation Links
Drug May Be Dangerous for Kids With Graves' Disease
Date:4/17/2009

Medication known as PTU can cause liver disease, experts say

FRIDAY, April 17 (HealthDay News) -- A recommendation to restrict the use of the antithyroid drug (PTU) in children has been endorsed by the Endocrine Society.

In a letter to the editor in the April 9 New England Journal of Medicine, two experts wrote that PTU can cause severe liver disease in children and should no longer be used as a first-line treatment for children with Graves' disease, a disorder in which the thyroid gland produces more thyroid hormone than the body needs.

Liver damage has not been seen in children treated with the other thionamide derivative, methimazole, noted Dr. Scott A. Rivkees, of Yale University Medical School, and Dr. Donald R. Mattison, of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

The Endocrine Society said this week that it supports the recommendation.

"Despite the relative rarity of Graves' disease in the young, children and adolescents account for as many as 13 of 42 cases of serious PTU-related liver failure reported to date in the medical literature and a similar disproportionate number (4 of 13) of those requiring liver transplant for this indication between 1990-2002," the society said in a news release.

An estimated 40,000 children are treated for Graves' disease each year in the United States. If 40 percent of those children are treated with PTU, then as many as one to two of those children could develop severe liver disease that could lead to a liver transplant or death.

"Even one excess death is too many if it can be prevented," the society said. It suggested that until more study was done, methimazole ought to be considered the preferred treatment for children.

More information

The U.S. National Endocrine and Metabolic Diseases Information Service has more on Graves' disease.



-- Robert Preidt



SOURCE: The Endocrine Society, news release, April 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Grapefruit-Heavy Diet Helped Spur Dangerous Clot
2. Americans United for Life Condemns Ruling Increasing Minors Access to Dangerous Plan B
3. Research Finds Popular Household Pets Transmit Dangerous Parasites to Humans
4. Obesity linked to dangerous sleep apnea in truck drivers
5. Study finds cannabis use, dangerous driving behaviors interrelated
6. Supreme Court Ruling is a Victory for Consumers Injured by Dangerous Drugs, Says Hissey Kientz, LLP
7. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
8. Arab-American women need supplement to boost dangerously low vitamin D levels
9. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
10. Cell phones dangerous for child pedestrians, UAB study finds
11. X-Tremely Dangerous Sports
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug May Be Dangerous for Kids With Graves' Disease
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: