Navigation Links
Drug Limits Stomach Trouble in Patients Taking Low-Dose Aspirin
Date:7/6/2009

Study found famotidine effective at curtailing ulcers

MONDAY, July 6 (HealthDay News) -- The drug famotidine prevents stomach and upper-intestinal ulcers in people taking low-dose aspirin, often to reduce the risk of heart attack, a new British study finds.

The phase III trial included 404 patients taking 75 milligrams to 325 milligrams of aspirin a day. They were randomly selected to take either 20 milligrams of famotidine or a placebo twice a day. After 12 weeks, all the participants underwent an endoscopic exam.

Stomach ulcers were found in 3 percent of the patients taking famotidine and in 15 percent of those taking the placebo, the researchers found. Upper-intestinal (duodenal) ulcers were found in 0.5 percent of the famotidine group and in 17 percent of the placebo group. Gullet ulcers were found in 4 percent of the famotidine group and in 19 percent of the placebo group.

"Famotidine is effective in the prevention of gastric and duodenal ulcers and erosive esophagitis in patients taking low-dose aspirin," concluded Dr. Ali S. Taha, of the University of Glasgow, and colleagues.

The findings from the FAMOUS trial were published online July 6 in The Lancet, and will appear in an upcoming print issue.

Famotidine lowers acidity by binding to histamine particles in the stomach. The drug is broken down by enzymes in the liver. The drug may offer an alternative to proton pump inhibitors (PPIs), which can prevent ulcers in people taking low-dose aspirin to protect against heart disease and a number of other conditions. There are concerns about the cost and safety of PPIs, along with the risk of interaction with clopidogrel (Plavix), another anti-clotting drug that's often prescribed with aspirin, according to background information in a journal news release.

"There is little doubt that aspirin and other anti-clotting drugs are very useful in the prevention of heart, brain and other vascular diseases, hence their increasing use worldwide. Patients on such drugs should continue using them as advised by their family doctors or hospital specialists. However, everybody should be aware that aspirin use can also be associated with a variety of gastrointestinal or digestive system problems, which sometimes can be serious. The results of this research widen the options for the prevention of such problems particularly when more than one clotting drug is required," the study authors wrote.

More information

The U.S. Food and Drug Administration has more about the use of low-dose aspirin to reduce the risk of heart attack and stroke.



-- Robert Preidt



SOURCE: The Lancet, news release, July 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Study Shows Arthritis Significantly Limits Millions of Americans Ability to Work
2. Certain Cholesterol Drugs Show Their Limits
3. Activating protein enhances average lifespan, limits age-related disease in mice
4. Key Protein Limits Damage of Heart Attack
5. For Inspiring Amputee Its No Excuses, No Limits
6. Ironman Competitor with Diabetes Encourages Others to Live Without Limits; Competes in Ironman Arizona in Tempe
7. Calorie restriction limits and obesity fuels development of epithelial cancers
8. Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
9. Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where Life Has No Limits
10. Mary Hall, CEO of iHealthSpot, Inc., is Awarded Membership Into Fort Lauderdale City Limits "Profiles of Excellence"
11. States View Limits on Retiree Health Benefits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, a ... Miami, and Raleigh regions, is organizing an extended charity drive to benefit the ... chromosome abnormality. , After struggling since birth with several health challenges, T.J. was ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The American ... to become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer ... Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... a national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel ... also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... Sept. 12, 2017   EcoVadis , the leading platform for environmental, ... first annual edition of its Global CSR Risk and Performance Index. The ... EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points across ... ... ...
Breaking Medicine Technology: