Navigation Links
Drug Limits Stomach Trouble in Patients Taking Low-Dose Aspirin
Date:7/6/2009

Study found famotidine effective at curtailing ulcers

MONDAY, July 6 (HealthDay News) -- The drug famotidine prevents stomach and upper-intestinal ulcers in people taking low-dose aspirin, often to reduce the risk of heart attack, a new British study finds.

The phase III trial included 404 patients taking 75 milligrams to 325 milligrams of aspirin a day. They were randomly selected to take either 20 milligrams of famotidine or a placebo twice a day. After 12 weeks, all the participants underwent an endoscopic exam.

Stomach ulcers were found in 3 percent of the patients taking famotidine and in 15 percent of those taking the placebo, the researchers found. Upper-intestinal (duodenal) ulcers were found in 0.5 percent of the famotidine group and in 17 percent of the placebo group. Gullet ulcers were found in 4 percent of the famotidine group and in 19 percent of the placebo group.

"Famotidine is effective in the prevention of gastric and duodenal ulcers and erosive esophagitis in patients taking low-dose aspirin," concluded Dr. Ali S. Taha, of the University of Glasgow, and colleagues.

The findings from the FAMOUS trial were published online July 6 in The Lancet, and will appear in an upcoming print issue.

Famotidine lowers acidity by binding to histamine particles in the stomach. The drug is broken down by enzymes in the liver. The drug may offer an alternative to proton pump inhibitors (PPIs), which can prevent ulcers in people taking low-dose aspirin to protect against heart disease and a number of other conditions. There are concerns about the cost and safety of PPIs, along with the risk of interaction with clopidogrel (Plavix), another anti-clotting drug that's often prescribed with aspirin, according to background information in a journal news release.

"There is little doubt that aspirin and other anti-clotting drugs are very useful in the prevention of heart, brain and other vascular diseases, hence their increasing use worldwide. Patients on such drugs should continue using them as advised by their family doctors or hospital specialists. However, everybody should be aware that aspirin use can also be associated with a variety of gastrointestinal or digestive system problems, which sometimes can be serious. The results of this research widen the options for the prevention of such problems particularly when more than one clotting drug is required," the study authors wrote.

More information

The U.S. Food and Drug Administration has more about the use of low-dose aspirin to reduce the risk of heart attack and stroke.



-- Robert Preidt



SOURCE: The Lancet, news release, July 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Study Shows Arthritis Significantly Limits Millions of Americans Ability to Work
2. Certain Cholesterol Drugs Show Their Limits
3. Activating protein enhances average lifespan, limits age-related disease in mice
4. Key Protein Limits Damage of Heart Attack
5. For Inspiring Amputee Its No Excuses, No Limits
6. Ironman Competitor with Diabetes Encourages Others to Live Without Limits; Competes in Ironman Arizona in Tempe
7. Calorie restriction limits and obesity fuels development of epithelial cancers
8. Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
9. Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where Life Has No Limits
10. Mary Hall, CEO of iHealthSpot, Inc., is Awarded Membership Into Fort Lauderdale City Limits "Profiles of Excellence"
11. States View Limits on Retiree Health Benefits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... 03, 2016 , ... Sue Desmond-Hellmann, chief executive officer of the Bill & ... of human possibility in her keynote address at Georgia State University’s spring commencement ... on her rich experience as a scientist, physician and executive, Desmond-Hellmann leads the Gates ...
(Date:5/3/2016)... , ... May 03, 2016 , ... ... brainsalvation tool – a web application that helps people assess their risk of ... brainsalvation™ web app will provide users a “Risk Reduction Score™” that summarizes how ...
(Date:5/3/2016)... ... , ... Registration is now open for the 31st annual AIDS Walk Boston & 5K ... on the Esplanade. The event regularly draws thousands of participants, making it AIDS Action Committee’s ... fully sanctioned by the USA Track & Field Association. , The AIDS Walk & ...
(Date:5/3/2016)... ... 03, 2016 , ... Sandbox, one of the nation’s leading ... the newly created position of executive vice president, chief creative officer.     , In ... Chicago and LA offices. He reports to Nancy Finigan, president of those offices. ...
(Date:5/3/2016)... ... 03, 2016 , ... BioPlus Specialty Pharmacy (BioPlus), one ... 2016 Asembia Specialty Pharmacy Summit held May 2-6, 2016 at the Wynn & ... conference for the specialty pharmacy industry, with thousands of pharmacy providers, pharma/biotech manufacturers, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... LAKE OSWEGO, Ore. , May 3, 2016 /PRNewswire/ ... about the importance of extending care beyond the implant ... Scientific Sessions, May 4-7 in San Francisco ... tasked with continually delivering the highest quality of patient ... ensuring patients are cared for each and every tomorrow," ...
(Date:5/3/2016)...  Specialty Silicone Fabricators is offering teachers a ... cleanroom works. The free visual aid provides a ... Chris Mazelin , SSF ... enthusiastically supports the Science, Technology, Engineering and Math ... generation of innovators. We want to provide resources ...
(Date:5/3/2016)... , May 3, 2016 ... heute bekannt, dass sie einen entscheidenden Meilenstein ... haben: Ein Aufruf zum Handeln, um Patientenresultate ... Veröffentlichung trägt zu Fortschritten im Verständnis der ... hervor, ein Bewusstsein für Hepatische Enzephalopathie in ...
Breaking Medicine Technology: