Drug Inhibits Colon Cancer in Mice( Treated with enzastaurin even tumors ...),Health
Navigation Links
Drug Inhibits Colon Cancer in Mice
Date:2/12/2009
Treated with enzastaurin, even tumors that did develop weren't as advanced, study finds
THURSDAY, Feb. 12 (HealthDay News) -- A drug called enzastaurin significantly reduced the development of colon cancer in mice, and tumors that did develop were less advanced and aggressive than those in mice that didn't receive the drug, according to a study by researchers at the Mayo Clinic in Florida.
The findings, coupled with the fact that the drug appears to have minimal side effects, suggest that enzastaurin might offer an effective chemopreventive treatment in people at high risk for colon cancer, the researchers said. The study is to be published in the Feb. 15 issue of the journal Cancer Research.
"There is a need for an agent that has a proven ability to reduce colon cancer risk, and this study suggests that enzastaurin could be uniquely effective," senior investigator Nicole Murray, of the department of cancer biology, said in a Mayo news release.
Enzastaurin is designed to suppress signaling through the PKC-beta pathway. In a previous study, the Mayo team found that the pathway is necessary for the start of colon cancer in mice exposed to a carcinogen.
"These mice develop tumors similar to tumors found in humans, but mice without the PKC-beta gene do not," Murray said.
In the new study, the Mayo researchers gave enzastaurin daily to one group of mice and then exposed them, as well as a control group of mice that didn't receive the drug, to a carcinogen that causes colon tumors.
After 22 weeks, 50 percent of the treated mice and 80 percent of the untreated mice had developed tumors. The tumors that did develop in the treated mice were not as advanced as those in the untreated mice.
Enzastaurin is currently being tested to treat a range of human cancers, including B-cell lymphoma and high-grade brain gliomas.
More information
The U.S. National Ca
'/>"/>
| Copyright©2009 ScoutNews,LLC. All rights reserved |
Related medicine news :
1. Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
2. Herpes drug inhibits HIV replication, but with a price
3. Grapefruit Compound Inhibits Hepatitis C Virus
4. Calorie restriction inhibits, obesity fuels development of epithelial cancers
5. Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
6. Ingredient found in green tea significantly inhibits breast cancer growth in female mice
7. Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
8. Embryonic Stem Cell Protein Inhibits Melanoma
9. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
10. Helicobacter pylori inhibits intercellular communication of cultured gastric cells
11. Rural Areas Able to Increase Colon Cancer Screenings
Post Your Comments:
Related Image:
 Drug Inhibits Colon Cancer in Mice |
(Date:11/20/2009)...otentially adding to preemie delivery rate, expert...s) -- Recent reports show that the rate of preterm...s. Now, a new study suggests one reason why: Many...term birth in the first place. , About one-quar...d a baby born at 34 to 36 weeks of gestation to be...
(Date:11/20/2009)...n with seasonal flu , , FRIDAY, Nov. 20...rting that children with asthma are more likely to...u. , "Asthma has been identified as a significa...fluenza, present in 21 percent to 30 percent in th...w researchers from the Hospital for Sick Children ...
(Date:11/20/2009)...warns against the new breast cancer recommendation...Force. These guidelines may be cost-effective, but... wrong to be safe than sorry? , ...ce recommendations, published in the current issue... firestorm in the medical community. Major medical...
(Date:11/20/2009)...wswire/ -- Missouri state employees in the Southwe...e the option to choose Mercy Health Plans thanks t...nsolidated Health Care Plan (MCHCP) and Mercy Heal...ssouri regions include the following counties: Bar...s, Greene, Hickory, Howell, Jasper, Laclede, Lawre...
(Date:11/20/2009)...0 California minority advocacy gro...he Wall/Las Memorias, Latina Breast Cancer Agency,... Real Medicine Foundation today sent a letter to B... reconsider harmful and discriminatory coverage po...ly calls for an end to the practice of step therap...
Breaking Medicine News(10 mins):Health News:Many Women Miscalculate Time to Full-Term Birth 2Health News:Many Women Miscalculate Time to Full-Term Birth 3Health News:Many Women Miscalculate Time to Full-Term Birth 4Health News:New Breast Cancer Recommendation May Cost Lives While Saving Money 2Health News:New Breast Cancer Recommendation May Cost Lives While Saving Money 3Health News:Missouri Consolidated Health Care Plan Provides Mercy Health Plans Option 2Health News:California Minority Advocacy Groups Send Letter to Blue Shield of California Calling for an End to Discriminatory Practice that Denies Patients in Pain Access to Proper Medication 2Health News:California Minority Advocacy Groups Send Letter to Blue Shield of California Calling for an End to Discriminatory Practice that Denies Patients in Pain Access to Proper Medication 3Health News:California Minority Advocacy Groups Send Letter to Blue Shield of California Calling for an End to Discriminatory Practice that Denies Patients in Pain Access to Proper Medication 4[0] Many Women Miscalculate Time to Full-Term Birth[0] Swine Flu May Hit Kids With Asthma Harder[1] New Breast Cancer Recommendation May Cost Lives While Saving Money [0] Missouri Consolidated Health Care Plan Provides Mercy Health Plans Option[0] California Minority Advocacy Groups Send Letter to Blue Shield of California Calling for an End to Discriminatory Practice that Denies Patients in Pain Access to Proper Medication
...earchers in the US felt that artistic skill is oft...nown how the brain influences artistic creativity....oke, dementia, or trauma// - would destroy your ab...visual art, fared when they suffered some kind of ...
...ording to pshycologists, believing that one can c...ur heart and circulation.// Exposure to a stressfu...use it increases blood pressure and resistance to ...moderated by many psychological factors, such as p...
...roup scientists have recently helped the Communica...re strain of cholera, which wreaked havoc in coast...athogen, transmitted through sea food, has become ...ns made the discovery. “We received calls from the...
...rological diseases seen in people who were student...y to develop. Amyotropic lateral sclerosis (ALS)//...tion. It's sometimes known as Lou Gehrig's disease...ng ALS, as well as motor neurone disease, which is...
...ording to a notice distributed by the agency, the ... United Therapeutics Corp.'s pulmonary arterial hy.... A spokesperson for the FDA told Reuters Health t...ting clearance based on an effect// on a surrogate...
...ording to new study some light was thrown on the v...ted by the condition. The study focuses on the ris.../ At least 2 percent of the population is born wit...hat eye. Some, but not all, countries place high i...
Other Medicine News:(Date:11/19/2009)... , ARDEE, Ireland, Nov. 19 W...d the pricing of its previously announced secondar... a price to the public of $22.25 per share. The s...Bain Capital Partners, DLJ Merchant Banking, J.P. ...as H. Lee Partners, L.P., certain other institutio...
(Date:11/19/2009)... , MOUNTAIN VIEW, Calif., Nov. 19 /PRNewswire...q: ALXA ) announced today that its corporate pres...al Piper Jaffray Health Care Conference on Wednesd...he presentation will be webcast from The New York ...Thomas B. King, Alexza President and CEO. ,, ...
(Date:11/19/2009)... , Part of International Internet Week of...wire-USNewswire/ -- The U.S. Food and Drug Adminis...nternational effort, called the International Inte...al actions involving medical products. ,, (Logo...ALOGO ) ,, During the effort, the FDA,s Office ...
Breaking Medicine Technology:Warner Chilcott Prices Secondary Equity Offering 2Warner Chilcott Prices Secondary Equity Offering 3Warner Chilcott Prices Secondary Equity Offering 4Alexza Pharmaceuticals to Present at the 21st Annual Piper Jaffray Health Care Conference 2Alexza Pharmaceuticals to Present at the 21st Annual Piper Jaffray Health Care Conference 3UPDATE: FDA Issues 22 Warning Letters to Web site Operators 2Biocartis Raises EUR10 Million in Series A Financing Round 5498 1Biocartis Raises EUR10 Million in Series A Financing Round 5498 2Biocartis Raises EUR10 Million in Series A Financing Round 5498 3Cord Blood America Details Las Vegas Laboratory Progress in Analyst Interview 5496 1Cord Blood America Details Las Vegas Laboratory Progress in Analyst Interview 5496 2Cord Blood America Details Las Vegas Laboratory Progress in Analyst Interview 5496 3Clinical Force Announces that Stiris Research has Selected the Clinical Force CTMS to Manage Clinical Trials 14476 1Clinical Force Announces that Stiris Research has Selected the Clinical Force CTMS to Manage Clinical Trials 14476 2Clinical Force Announces that Stiris Research has Selected the Clinical Force CTMS to Manage Clinical Trials 14476 3... England, April 21 Circassia Ltd, a specialty,bio...ed today that it has,initiated a phase II clinical...patients with asthma. The trial builds on positive...clinical benefits of ToleroMune allergy,therapy, a...llergy-associated,asthma. , The lastest study,...
...2905 , , DENVER, April 20 Scientists from the Ba...ay presented data at the American Association for ...epresents significant research advancements in the...e breast cancer. , , (Logo: http://www.newscom.c...nos researchers discovered that when an FDA-approv...
Other Medicine Technology:Circassia's Allergy Therapy Begins Phase II Clinical Trial in Asthma Patients 2Karmanos Cancer Institute Researchers Present Breast Cancer Advancements at Conference 2Karmanos Cancer Institute Researchers Present Breast Cancer Advancements at Conference 3| Copyright © 2003-2009 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |