Navigation Links
Drug Improves Survival in Mice With Brain Tumors
Date:4/2/2009

Cediranib reduces tissue swelling better than steroids, team says

THURSDAY, April 2 (HealthDay News) -- Anti-angiogenesis drugs reduce edema (swelling of brain tissue) caused by deadly brain tumors called glioblastomas, a new study suggests.

Anti-angiogenesis drugs prevent the formation of new blood vessels that tumors need to grow, the researchers pointed out.

In this study, a Massachusetts General Hospital team found that the experimental anti-angiogenesis drug cediranib reduced edema and improved survival in mice with glioblastomas. The drug inhibits an angiogenesis factor called VEGF, which is abundant in glioblastomas.

"Our findings suggest that anti-angiogenesis therapy can increase patient survival even in the face of persistent tumor growth," study co-senior author Rakesh K. Jain, director of the Steele Laboratory in MGH's radiation oncology department, said in a hospital news release. "In glioblastoma clinical trials, it is important to separate survival analysis from that of tumor response to therapy, since many factors combine to cause patient deaths."

Previous research showed that cediranib temporarily normalized abnormal, leaky blood vessels that had recurred after surgery, radiation or chemotherapy for glioblastoma, reducing edema and the size of tumors. But exactly how the drug did this was unclear. This study clarified that cediranib's beneficial effects resulted from reduction of edema, the study authors said.

"This is the first paper to show that vascular normalization alone, without chemotherapy, can be effective against some tumors by controlling edema, and that this anti-edema effect is better than that of currently used steroids," Jain said.

"Unfortunately, these anti-VEGF agents did not slow the tumor growth rate in these [mouse] models; and since recurrent glioblastomas are highly resistant to currently used chemotherapy drugs, even if vascular normalization i
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
2. Exercise and yoga improves quality of life in women with early-stage breast cancer
3. Enhanced PrecyseCode 2X(TM) Further Accelerates Remote Coding and Improves Cash Flow for Hospitals
4. Weight-based dosing of ribavirin improves outcomes for patients with hepatitis C
5. Kerry Extends, Improves Small Business Innovation Program
6. Thalidomide Improves Outcomes for Older Myeloma Patients
7. Grape Consumption Improves Antioxidant Capacity in Humans
8. JCSM: CPAP therapy improves symptoms of depression in OSA patients
9. Early intervention dramatically improves outcomes for new dialysis patients
10. New technique improves purity of medicines
11. Novel medication improves ovarian cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Improves Survival in Mice With Brain Tumors
(Date:8/4/2015)... ... ... How cool is it to check in at your favorite place and ... will soon allow you to do just that. , Ahhaa is releasing the next ... feature. , Users will soon get to share what inspires them about their favorite ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... it has joined the American Association of Tissue Banks (AATB) as an Affiliate ... its mission “to honor donors, and to save and improve lives by promoting ...
(Date:8/4/2015)... FL (PRWEB) , ... August 04, 2015 , ... ... testing organization which provides vascular, electrocardiogram (EKG), echocardiogram, and NCV testing, announced their ... has been successfully identifying previously undiagnosed cardiovascular abnormalities one program at a time. ...
(Date:8/4/2015)... ... 2015 , ... Angelina Jolie is in it at age 39. “It” is ... Dr. Angela DeRosa, DO, MBA, CPE aka “Dr. Hot Flash,” arguably the Southwest’s ... of menopause. , Myth #1: Menopause only affects old ladies. – Menopause can ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... Food,” scheduled for Nov. 3 – 4, 2015, at UC San Diego, will ... new businesses, improve food access, and manage resources efficiently against the dueling backdrop ...
Breaking Medicine News(10 mins):Health News:Ahhaa App Soon to Release the "Now" Feature 2Health News:Exsurco Medical Joins AATB as Affiliate Member 2Health News:Colleges and High Schools Across the Country Are Joining the Wimbledon U Team Uncovering Unknown Cardiac Conditions and Promoting Heart Healthy Athletes 2Health News:Colleges and High Schools Across the Country Are Joining the Wimbledon U Team Uncovering Unknown Cardiac Conditions and Promoting Heart Healthy Athletes 3Health News:"Dr. Hot Flash" Debunks the Top 5 Menopause Myths 2Health News:"Dr. Hot Flash" Debunks the Top 5 Menopause Myths 3Health News:Diversity of Urban and Hydroponic Farms of the Future to Highlight Seedstock Annual Conference Field Trip 2Health News:Diversity of Urban and Hydroponic Farms of the Future to Highlight Seedstock Annual Conference Field Trip 3
... by researchers at Columbia University,s Mailman School of Public ... children of a group of ubiquitous chemicals known as ... known to disrupt the endocrine system, and are widely ... household building materials, to shampoos. Recent studies of ...
... Psychogenic non-epileptic seizures may go undiagnosed for much longer in ... in the September 6, 2011, print issue of Neurology ... This type of seizure is different from seizures related to ... "People with psychogenic seizures are often diagnosed with epilepsy and ...
... in the Archives of General Psychiatry suggest that certain variants ... related to mood), may serve as a useful predictor of ... a trauma. "One of the critical questions surrounding ... the disorder following a trauma, while others appear to be ...
... Mann HealthDay Reporter , MONDAY, Sept. 5 ... are receiving their recommended vaccines, which could indicate that ... States. "We are getting better, but we still ... Rodewald, director of the immunization services division at the ...
... 5 (HealthDay News) - Rudeness among co-workers can have negative ... shows. Researchers from Baylor University found people who endure ... which can have negative effects on their family and marriages ... that when employees go home stressed and distracted, their partners ...
... , This press release is available in French ... by the European College of Neuropsychopharmacology (ECNP) sheds new light ... study finds reveal that mental disorders have become Europe,s largest ... that the majority of mental disorders remain untreated. Taken together ...
Cached Medicine News:Health News:Prenatal exposure to phthalates linked to decreased mental and motor development 2Health News:Non-epileptic seizures may be misdiagnosed longer in veterans 2Health News:The search for predictors of risk for PTSD 2Health News:More U.S. 'Tweens' Getting Recommended Vaccines 2Health News:More U.S. 'Tweens' Getting Recommended Vaccines 3Health News:Boorish Co-Workers Can Damage Your Home Life 2Health News:The size and burden of mental disorders in Europe 2Health News:The size and burden of mental disorders in Europe 3
(Date:8/4/2015)... , August 4, 2015 ... report with market overview, trends, DRO analysis, market ... developments, competitive scenario and top competitor profiles in: ... Testing Market Development and Demand Forecast to ... , Explore full reports with detailed ...
(Date:8/4/2015)... 2015 Organovo Holdings, Inc. (NYSE MKT: ... delivering scientific and medical breakthroughs using 3D bioprinting ... Paul Gallant as its General Manager ... business. Mr. Gallant has more than 20 years of ... industry, most recently serving as chief operating officer ...
(Date:8/4/2015)... , Aug. 04, 2015 ... announced the addition of Jain PharmaBiotech,s new report ... to their offering. This report ... in veterinary medicine and pharmaceuticals as well as ... is important in the application of biotechnology to ...
Breaking Medicine Technology:Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 3Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 4Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 5Organovo Holdings, Inc. Appoints Paul Gallant as General Manager 2Organovo Holdings, Inc. Appoints Paul Gallant as General Manager 3Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 2Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 3
... WIRE)--May 30, 2007 - INNOVIVE Pharmaceuticals,Inc. (OTCBB: ... a Phase I,trial of INNO-406, an orally ... or,treatment-intolerant chronic myelogenous leukemia, will be,presented at ... Annual,Meeting. The meeting takes place June 1- ...
... from various,clinical studies including a pivotal Phase III trial ... Nexavar (sorafenib) tablets will be presented at the Annual,Meeting ... USA from June 1 - 5, 2007. , On ... be held on June 4, 2007. Starting at around ...
Cached Medicine Technology:Innovive Pharmaceuticals to Present Interim Data from Phase I Study,of INNO-406 at the American Society of Clinical Oncology Annual,Meeting 2
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medicine Products: