Navigation Links
Drug Impedes Body's Deadly Reaction to Flu Virus
Date:1/23/2009

Finding may help prevent spread of lung infections, including pandemic strains

FRIDAY, Jan. 23 (HealthDay News) -- A drug may be able to dampen part of the body's immune response so infections can be fought without a resulting overkill that may cause the person to perish, a new study says.

The compound sphingosine analog AAL-R, when administered directly into the lungs of mice, helped mitigate the cytokine response, a common immune reaction that can sometimes be so strong that it can harm as much as help, according to a report published in this week's issue of the Proceedings of the National Academy of Sciences. A severe "cytokine storm" can flood and clog the lung's alveoli with infection-fighting cells, making it so oxygen can no longer be properly absorbed by the body.

When administered to mice with the flu virus, the compound helped to temper the cytokine effect enough to prevent harm to the rodent while still allowing the body to fight the infection.

"Even though this compound does not kill the virus itself, the immunopathologic response was significantly impaired," study co-leader Dr. Michael Oldstone, of The Scripps Research Institute, said in a news release issued by the facility.

The researchers believe their findings may help prevent a much-feared pandemic of the H5N1 virus, more commonly known as bird flu, and the spreading of other deadly lung infections by helping make treatment more effective without harming the patient.

"We know that many of those who died in the 1918 influenza pandemic were young people, those with the strongest immune systems whose bodies mounted the strongest immunopathologic responses," Oldstone said. "Our hope is that our current research will yield answers about how to treat this kind of immune response not only in influenza, but also in other viral diseases such as hantavirus and SARS, in which pulmonary infiltration is severe."

They plan to study how sphingosine analog AAL-R receptors work and test combination therapy, such as adding Tamiflu to the compound, as a way to kill the virus while managing the immunopathologic response.

More information

The U.S. Centers for Disease Control and Prevention has more about the flu virus.



-- Kevin McKeever



SOURCE: The Scripps Research Institute, news release, Jan. 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
2. Scientists Probe Sepsis Deadly Secrets
3. HIV denialists spread misinformation online -- consequences could be deadly; and more
4. Greeks get space-based help in wake of deadly fires
5. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
6. Drug combination might offer hope for patients deadly brain tumors
7. MARCOR Responds to Deadly MRSA Outbreak
8. Common virus may help doctors treat deadly brain tumors
9. A new key to detecting deadly aortic aneurysms
10. Genes Unlock New Treatments for Deadly Melanoma
11. Northwestern exposing most deadly infectious diseases in 3-D
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Impedes Body's Deadly Reaction  to Flu Virus
(Date:12/9/2016)... PA (PRWEB) , ... December 09, 2016 , ... An ... permit amputees to safely ride all types of amusement park rides. , The patent-pending ... the unit is easy to use and could be set up in a matter ...
(Date:12/9/2016)... ... December 09, 2016 , ... ... Pennsylvania Cable Network (PCN) during the summer of 2016. The program was made ... by the United States Department of Health and Human Services Administration. The ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for Input ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate that ...
(Date:12/8/2016)... ... ... David J. Dykeman , Ginger Pigott , and J. Rick ... West, Dec. 12, 2016, at the Fairmont Newport Beach in California. Greenberg Traurig is ... Sciences & Medical Technology Group have been featured speakers at every DeviceTalks conference since ...
(Date:12/8/2016)... ... 2016 , ... STATEN ISLAND, N.Y., Nov. 24, 2016 — ... highest standards of trauma, maternity, cancer and chronic obstructive pulmonary disease (COPD) services ... Daniel Messina. , Among the recognitions, the American College of Surgeons' (ACS) named ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... KEY FINDINGS North America ... market in 2016 and is expected to continue in ... a large number of surgical procedures that are taking ... in the patient temperature management market.) Patient warming and ... of blood during surgeries, lowering the risks of neurological ...
(Date:12/8/2016)... , Dec 8, 2016 Research and ... Market Analysis and Trends - Adhesion Type, Application, Usability - Forecast ... ... Global Cardiology Electrodes Market is poised to grow at a CAGR ... trends that the market is witnessing include advancements in extracellular microelectrode ...
(Date:12/8/2016)... , Dec. 8, 2016  Valeant Pharmaceuticals ... TSX: VRX) ("Valeant") today announced positive results from ... study to assess the safety and efficacy of ... treatment of plaque psoriasis. Within ... with moderate to severe psoriasis, IDP-118 showed statistical ...
Breaking Medicine Technology: