Navigation Links
Drug Impedes Body's Deadly Reaction to Flu Virus
Date:1/23/2009

Finding may help prevent spread of lung infections, including pandemic strains

FRIDAY, Jan. 23 (HealthDay News) -- A drug may be able to dampen part of the body's immune response so infections can be fought without a resulting overkill that may cause the person to perish, a new study says.

The compound sphingosine analog AAL-R, when administered directly into the lungs of mice, helped mitigate the cytokine response, a common immune reaction that can sometimes be so strong that it can harm as much as help, according to a report published in this week's issue of the Proceedings of the National Academy of Sciences. A severe "cytokine storm" can flood and clog the lung's alveoli with infection-fighting cells, making it so oxygen can no longer be properly absorbed by the body.

When administered to mice with the flu virus, the compound helped to temper the cytokine effect enough to prevent harm to the rodent while still allowing the body to fight the infection.

"Even though this compound does not kill the virus itself, the immunopathologic response was significantly impaired," study co-leader Dr. Michael Oldstone, of The Scripps Research Institute, said in a news release issued by the facility.

The researchers believe their findings may help prevent a much-feared pandemic of the H5N1 virus, more commonly known as bird flu, and the spreading of other deadly lung infections by helping make treatment more effective without harming the patient.

"We know that many of those who died in the 1918 influenza pandemic were young people, those with the strongest immune systems whose bodies mounted the strongest immunopathologic responses," Oldstone said. "Our hope is that our current research will yield answers about how to treat this kind of immune response not only in influenza, but also in other viral diseases such as hantavirus and SARS, in which pulmonary infiltration is severe."

They plan to study how sphingosine analog AAL-R receptors work and test combination therapy, such as adding Tamiflu to the compound, as a way to kill the virus while managing the immunopathologic response.

More information

The U.S. Centers for Disease Control and Prevention has more about the flu virus.



-- Kevin McKeever



SOURCE: The Scripps Research Institute, news release, Jan. 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
2. Scientists Probe Sepsis Deadly Secrets
3. HIV denialists spread misinformation online -- consequences could be deadly; and more
4. Greeks get space-based help in wake of deadly fires
5. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
6. Drug combination might offer hope for patients deadly brain tumors
7. MARCOR Responds to Deadly MRSA Outbreak
8. Common virus may help doctors treat deadly brain tumors
9. A new key to detecting deadly aortic aneurysms
10. Genes Unlock New Treatments for Deadly Melanoma
11. Northwestern exposing most deadly infectious diseases in 3-D
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Impedes Body's Deadly Reaction  to Flu Virus
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, Inc. ... Day Software and Consulting, LLC , and named its ... Software, based in Tennessee , will ... Day expands EnvoyHealth,s service offerings for health care partners ... "In an interoperable world, ...
(Date:10/2/2017)... 2017 Halo Labs announces the European launch of their ... HORIZON at MIBio 2017 in Cambridge, U.K ... matter in biopharmaceutical samples with unprecedented speed and sensitivity while using ... Backgrounded Membrane Imaging. ... subvisible particle analysis system ...
(Date:9/28/2017)... WASHINGTON , Sept. 28, 2017 Cohen ... to advance the use of wearable and home sensors ... brain disorders. Early Signal Foundation, a nonprofit organization focused ... populations, will provide an affordable analytical system to record ... ...
Breaking Medicine Technology: