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Drug-Eluting Stents Beat Bare Metal Stents in Diabetics
Date:11/11/2008

Study highlights:

-- Drug-eluting stents showed improved outcomes as compared with bare metal stents in diabetics.

-- No excess adverse events were found with drug-eluting stents in diabetic patients.

NEW ORLEANS, Nov. 11 /PRNewswire-USNewswire/ -- Drug-eluting stents reduced the risk of revascularization, heart attack and death in diabetics as compared with bare-metal stents in the largest observational comparison, researchers reported at the American Heart Association's Scientific Sessions 2008. The results from The Drug-eluting and Bare Metal Stenting in Patients with Diabetes Mellitus: Results from the Mass-DAC Registry, were presented as a late-breaking clinical trial. The study is simultaneously published in Circulation: Journal of the American Heart Association.

"We actually saw a significant benefit from using drug-eluting stents in this patient population," said Laura Mauri, M.D., M.Sc., principal investigator of the study and assistant professor of medicine at Brigham and Women's Hospital and Harvard Medical School in Boston, Mass. "First, they significantly reduced the need for repeat procedures which included repeat stenting or bypass surgery. Second, they were associated with lower rates of death and heart attack. So, as a result we can say that these stents appear to be safe in diabetic patients, whose diabetes puts them at higher risk of mortality and heart attack than the general population."

People with diabetes make up about a third of all patients undergoing percutaneous coronary interventions (PCI) to reopen blocked blood vessels. In PCI with stenting, a balloon-tipped catheter is threaded into the artery to the point of blockage. Then, the balloon is inflated to open the vessel and a mesh metal stent -- either bare-metal (BMS) or drug-eluting (DES) -- is inserted to keep the channel open. DES are coated with a drug that fights the proliferation of cells that can block the artery (called stenosis).

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SOURCE American Heart Association
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