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Drug Eases Gout Flare-ups in Some Patients: Study
Date:1/5/2012

By Alan Mozes
HealthDay Reporter

THURSDAY, Jan. 5 (HealthDay News) -- Preliminary findings suggest a drug used to treat another disease might also reduce painful flare-ups in gout patients starting new medication regimens.

In a new study, the protein-inhibitor drug rilonacept (Arcalyst) appeared to markedly lower the risk of gout flare-ups during the first few months of treatments aimed at lowering uric acid levels.

While effective in lowering the risk for gout attacks in the long-term, uric acid-lowering treatment can initially boost the risk for flare-ups as it breaks up and releases the uric acid crystal deposits at the source.

"To reduce deposits of crystals in the joints, we advise patients to initiate treatment with medications that lower levels of uric acid in the blood," study author Dr. H. Ralph Schumacher, Jr., a professor of medicine at the University of Pennsylvania School of Medicine, said in a journal news release.

Gout, a debilitating and painful form of inflammatory arthritis, now affects upwards of 8.3 million Americans, according to the release. Flare-ups , which involve excruciating joint pain, redness, swelling and warmth, can last days or weeks.

The researchers wanted to learn if rilonacept could lower this short-term risk for by neutralizing a specific target protein -- interleukin 1 or IL-1 -- before it initiates inflammation.

They looked at 83 gout patients in 27 U.S. study centers who had a history of gout flare-ups and high levels of uric acid. All were placed on a chronic uric-acid lowering regimen of the standard drug allopurinol.

About half were also given an initial double-dose injection of rilonacept (320 milligrams) followed by a single dose for 16 weeks. The other half received sugar pills.

Rilonacept patients were less likely to have flare-ups, with 15 percent experiencing flare-ups three-months into the study compared with 45 percent among the no
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