Navigation Links
Drug Could Make Melanoma More Vulnerable to Chemo
Date:3/6/2009

Compound disabled protein fueling tumor growth, making therapy more effective

FRIDAY, March 6 (HealthDay News) -- A compound that targets and disables a protein found in melanoma tumors may make the deadly skin cancer more vulnerable to chemotherapy, early results of a pilot study show.

Sixteen patients with advanced melanoma on an extremity (feet, hands, etc.) were given the compound ADH-1 intravenously and then underwent chemotherapy by infusion in the affected limb. The melanoma was eradicated in half the patients.

The findings were expected to be presented Friday at the Society of Surgical Oncology annual meeting in Phoenix, and have been accepted for publication in the journal Cancer. The study was funded by Adherex Technologies, which is developing ADH-1.

"These early results are very exciting, because metastatic melanoma is one of the most deadly cancers and one which is typically very unresponsive to therapy," lead author Dr. Georgina Beasley, a surgical resident at the Duke Comprehensive Cancer Center, said in a university news release. "The next step will be to continue testing the efficacy of this treatment in more patients, here and at other centers."

A Phase II trial involving 46 patients has recently completed recruiting participants.

The incidence of melanoma is increasing at a rate faster than any other cancer, and 60,000 new cases of melanoma will be diagnosed in the United States this year, according to background information in the news release.

Melanoma often develops on extremities, and up to 10 percent of patients with extremity melanoma develop multiple recurrences that can't be treated with surgery alone. Melanoma that spreads beyond the primary site is rarely curable, and there are limited treatment options.

More information

The American Academy of Dermatology has more about melanoma.



-- Robert Preidt



SOURCE: Duke Medicine, news release, March 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Number of cardiovascular risk factors could determine safety of intravenous gammaglobulin treatment
2. Engineered Viruses Could Battle Superbugs
3. Stem cells could halt osteoporosis, promote bone growth
4. TB breakthrough could lead to stronger vaccine
5. Classifying concussions could help kids
6. Vegetable-based drug could inhibit melanoma
7. Report: Many Cancers Could Be Prevented in US
8. Landmark Policy Report: Many Cancers Could Be Prevented Across the Globe
9. Landmark Report: Many Cancers Could be Prevented
10. Economy could reduce colorectal cancer screening rate
11. UCSF Gallo Study Finds Hormone Disorder Drug Could Help Drinkers Stay Sober
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Could Make Melanoma More Vulnerable to Chemo
(Date:5/26/2017)... ... 26, 2017 , ... Leading CEOs from biotech, pharmaceutical, and ... 31st at The Four Seasons Hotel Boston. , The Boston CEO Conference ... exclusive access to key decision makers who influence deal making and investment. Attendees ...
(Date:5/26/2017)... ... 26, 2017 , ... Somnoware, a leading provider of digital ... its Somnoware Sleep Device Interface (SDI). Somnoware SDI is a sleep device integration ... platform, initializing devices and importing studies are just one-click operations. This plugin streamlines ...
(Date:5/26/2017)... ... May 26, 2017 , ... via ... antimicrobial, mesh back 24/7 task chair specifically designed for clinical areas. Genie Copper ... thrilled to partner with Cupron® to provide customers with a game changing chair ...
(Date:5/26/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in ... Peace Agreements being discussed by President Donald Trump and the rest of the world. ... speed up peace talks in the continuous battle between Israel and Palestine. The world’s ...
(Date:5/26/2017)... Francisco, CA (PRWEB) , ... May 26, 2017 , ... ... Francisco, is proud to announce a new, informational blog post on insurance options. If ... surgery, checking insurance plans may help save time and money. Visiting an in-network provider ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 9, 2017  Oramed Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company focused on the development of oral ... Intellectual Property Office has granted Oramed a patent ... Exenatide". The patent covers Oramed,s invention of an ... is an incretin hormone that stimulates the secretion ...
(Date:5/8/2017)... May 8, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO)., ... ("WRB"), a health care service center company based ... WRB specializes in relationship management programs for leading pharmaceutical ... WRB will join Envoy Health ... services for manufacturers, biotech firms, and other service companies. ...
(Date:5/6/2017)... May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), ... 100,000 square feet to its Welch Allyn campus. ... commitment to bring more than 100 new jobs to ... Allyn has maintained a significant presence for more than ... new positions, a large portion of which will be ...
Breaking Medicine Technology: