Navigation Links
Drug Could Make Melanoma More Vulnerable to Chemo
Date:3/6/2009

Compound disabled protein fueling tumor growth, making therapy more effective

FRIDAY, March 6 (HealthDay News) -- A compound that targets and disables a protein found in melanoma tumors may make the deadly skin cancer more vulnerable to chemotherapy, early results of a pilot study show.

Sixteen patients with advanced melanoma on an extremity (feet, hands, etc.) were given the compound ADH-1 intravenously and then underwent chemotherapy by infusion in the affected limb. The melanoma was eradicated in half the patients.

The findings were expected to be presented Friday at the Society of Surgical Oncology annual meeting in Phoenix, and have been accepted for publication in the journal Cancer. The study was funded by Adherex Technologies, which is developing ADH-1.

"These early results are very exciting, because metastatic melanoma is one of the most deadly cancers and one which is typically very unresponsive to therapy," lead author Dr. Georgina Beasley, a surgical resident at the Duke Comprehensive Cancer Center, said in a university news release. "The next step will be to continue testing the efficacy of this treatment in more patients, here and at other centers."

A Phase II trial involving 46 patients has recently completed recruiting participants.

The incidence of melanoma is increasing at a rate faster than any other cancer, and 60,000 new cases of melanoma will be diagnosed in the United States this year, according to background information in the news release.

Melanoma often develops on extremities, and up to 10 percent of patients with extremity melanoma develop multiple recurrences that can't be treated with surgery alone. Melanoma that spreads beyond the primary site is rarely curable, and there are limited treatment options.

More information

The American Academy of Dermatology has more about

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Number of cardiovascular risk factors could determine safety of intravenous gammaglobulin treatment
2. Engineered Viruses Could Battle Superbugs
3. Stem cells could halt osteoporosis, promote bone growth
4. TB breakthrough could lead to stronger vaccine
5. Classifying concussions could help kids
6. Vegetable-based drug could inhibit melanoma
7. Report: Many Cancers Could Be Prevented in US
8. Landmark Policy Report: Many Cancers Could Be Prevented Across the Globe
9. Landmark Report: Many Cancers Could be Prevented
10. Economy could reduce colorectal cancer screening rate
11. UCSF Gallo Study Finds Hormone Disorder Drug Could Help Drinkers Stay Sober
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Could Make Melanoma More Vulnerable to Chemo
(Date:10/20/2014)... Akron, OH (PRWEB) October 20, 2014 ... new Assisted Living Center on Oct. 14. The $11 ... amenities and services, and a cooked-to-order kitchen with full-service ... forward Akron’s premier choice for first class Assisted Living ... groundbreaking. “Our residents deserve the highest quality of care ...
(Date:10/20/2014)... Final Cut Pro X Plugin developers from Pixel Film ... FCPX filmmakers . , “Fun, cool, and simple are ... Says Christina Austin, CEO of Pixel Film Studios. “It has ... comes with all the tools needed for a full ... added style, a title screen for an introduction, two lower ...
(Date:10/20/2014)... 2014 Houston plastic surgeon Dr. ... elements of his innovative True Form Tummy Tuck® ... residents and faculty at The University of Texas ... was once a medical student. Patronella, who is a ... plastic surgery practices in Texas, The Aesthetic Center ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 Recently, BambooIndustry.com, ... has unveiled its new range of bamboo deckings ... for these natural items; they are now available at ... most people, it is hard to overstate the significance ... of attention to online services. The company’s workers are ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest ... and HostMonster are the best VPS hosting suppliers ... is the method of partitioning a physical server ... the appearance and capabilities of running on someone’s ... pays close attention to VPS products and related ...
Breaking Medicine News(10 mins):Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2
... -- There may be a link between H. pylori ... study. In some people, an H. pylori infection ... lead to ulcers in the stomach and small intestine. These bacteria ... In this study, researchers analyzed data from people who took ...
... in Word War I. Although Brazil remained neutral during most ... the war effort against the central powers. It was the ... encountered an unexpected and treacherous enemy in the African coast ... for: the Spanish flu. The Spanish flu swept ...
... screening to identify people infected with hepatitis C ... to a new report published in Clinical ... ). Significantly reducing HCV-related mortality and morbidity, however, ... only increased testing but also linking those infected ...
... -- A Loyola University Chicago Stritch School of Medicine study ... protein that enables cancer cells to establish tumors in distant ... way to new drugs to prevent breast cancer and other ... Adriano Marchese, PhD and colleagues is published in the ...
... experiencing economic and social growth might also see growing ... study from Rice University and the University of Colorado. ... developing countries may improve conditions such as malnutrition and ... lower socio-economic status. "It,s a troubling finding," ...
... This release is available in German . ... of lipids that separates the distinct internal environment of the ... also referred to as plasma membrane, disturbs the cellular functions ... example, downhill walking tears many little holes into the plasma ...
Cached Medicine News:Health News:Type of Bacteria May Be Linked to Diabetes 2Health News:The Brazilian Navy faces its worst enemy in WWI: The Spanish flu 2Health News:Broader screening for hepatitis C would be cost effective, study suggests 2Health News:How cancer cells start new tumor sites 2Health News:Economic and social growth of developing nations may increase obesity 2Health News:How muscle cells seal their membranes 2
(Date:10/19/2014)... SEATTLE, Wash. , Oct. 20, 2014 ... today that it will report its third quarter 2014 ... close of the U.S. financial markets. Following the announcement, ... conference call to discuss the results and provide a ... PDT). Access to the event can be obtained as ...
(Date:10/18/2014)... 18, 2014  In a policy paper ... the nation,s largest lesbian, gay, bisexual and transgender ... of Truvada for Pre-Exposure Prophylaxis (PrEP). PrEP is ... prevent the spread of a disease or infection ... name anti-HIV drug combination currently approved for PrEP, ...
(Date:10/17/2014)... , Oct. 17, 2014  Hanger, Inc. (NYSE: ... to report its results of operations for the quarter ... after the market closes.  A conference call to discuss ... ET, on Friday, November 7, 2014. Those wishing to ... until Friday, November 14, 2014 by dialing 1-855-859-2056 and ...
Breaking Medicine Technology:CTI BioPharma to Report Third Quarter 2014 Financial Results on October 29, 2014 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3
8 inch Mayo-Hegar needle holder....
... a combination Spectral Optical Coherence Tomography (OCT) ... provides suberb, high-quality images of the vitreo-retina, ... of spectral technology, OTI's sytem can reach ... per second and provide images with a ...
... Digital Camera is a state-of-the-art, office-based nuclear cardiology ... provides full sized fields of view. When ... need a flexible system that can work around ... the Pulse reduces the costs of adding a ...
... is an ideal gamma camera ... the ability to perform bone ... Myocardial perfusion diagnosis and SPECT ... cost and space efficient solution ...
Medicine Products: