Navigation Links
Drug Combo May Offer Best Relief for Nerve Pain
Date:9/30/2009

People not helped by one medication feel better with two, study shows

TUESDAY, Sept. 29 (HealthDay News) -- People with nerve pain respond better to a combination treatment using the anticonvulsant gabapentin and antidepressant nortriptyline than to treatment with either drug alone, according to Canadian researchers.

The study findings suggest that combination treatment could be used to help people who only partially respond to one drug or the other.

Nerve, or neuropathic, pain -- which affects 2 to 3 percent of the population -- is "initiated or caused by a primary lesion or dysfunction in the nervous system," according to a news release from The Lancet, which is publishing the study online Sept. 29. Conditions that cause neuropathic pain include nerve problems in the spine, diabetes-related nerve damage and postherpetic neuralgia (PHN), which is nerve pain caused by the varicella zoster virus that can follow an outbreak of shingles.

The study included 56 people with PHN or diabetic nerve disease who had a daily pain score of at least 4 on a scale of 0 to 10. They were randomly selected to be given gabapentin alone, nortriptyline alone, or both drugs. Everyone received each type of treatment, with each treatment period lasting six weeks.

At the start of the study, the average daily pain level among the participants was 5.4. At maximum tolerated doses, average daily pain levels were 3.2 while people were taking gabapentin, 2.9 for while taking nortriptyline and 2.3 while taking the combination treatment, the researchers reported.

"This trial shows that combination of an antidepressant and an anticonvulsant drug seems to be superior to monotherapy for neuropathic pain," wrote study author Ian Gilron, director of clinical pain research at Queen's University and Kingston General Hospital in Ontario, and colleagues.

"Although development of more effective and better-tolerated monotherapies is much anticipated, our findings suggest that drug combinations represent the most effective strategy for many patients with neuropathic pain," the researchers concluded. "On the basis of our results, we recommend combined gabapentin and nortriptyline for patients who have a partial response to either drug alone and seek additional pain relief."

More information

The National Pain Foundation has more about neuropathic pain.



-- Robert Preidt



SOURCE: The Lancet, news release, Sept. 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... Alert Sentry Group LLC., a leader in the ... Systems), the iSAFE and the iSAFE Plus. These iSAFE products are the most affordable ... the iSAFE and iSAFE Plus offer direct GPS Location and two-way calling with the ...
(Date:3/28/2017)... Switzerland (PRWEB) , ... March 28, 2017 , ... ... for laboratory instruments are critical to ensuring high-quality results and maintaining GMP and ... Qualification of Laboratory Instruments in accordance with GMP requirements " these requirements are ...
(Date:3/28/2017)... Billerica, MA (PRWEB) , ... March 28, 2017 ... ... instrument for direct measurement of corrosive ions found in power plant water and ... plant components such as turbines and boilers, leading to extensive maintenance and unplanned ...
(Date:3/28/2017)... CA (PRWEB) , ... March 28, 2017 , ... ... which will be offered by the American Association of Integrative Medicine and available ... for healthcare providers at the AutismOne 2017 Conference in Colorado Springs. , Ed ...
(Date:3/28/2017)... CA (PRWEB) , ... March 28, 2017 , ... Silicon ... is proud to announce a new blog post about women’s hair loss. Although hair ... from hair loss as they age. Menopause or genetics can be two reasons a ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... 2017  CASI Pharmaceuticals, Inc. (Nasdaq: CASI), a ... and other unmet medical needs, announced today two ... Research annual meeting.  The first poster to be ... of ENMD-2076 in Combination with Anti-PD1 in Syngeneic ... be presented on April 4 is entitled " ...
(Date:3/28/2017)... , March 28, 2017 Elysium ... with Cambridge academic ...   The Milner Therapeutics Institute today announces Elysium ... Health has committed significant investment for collaborative projects with academic ... four years. This is the first major research investment outside ...
(Date:3/27/2017)...  A recent study at Shriners Hospitals for Children ... the country dedicated to the treatment of pediatric burns ... the Surfacide Helios ® UV-C Disinfection System is ... pathogens not killed by the EVS (manual) cleaning process ... Burn Association,s 49th Annual Meeting in Boston ...
Breaking Medicine Technology: