Navigation Links
Drug Combo Keeps Kidney Artery-Vein Grafts Viable
Date:5/20/2009

Aspirin plus anti-clotting therapy boosts dialysis patients' quality of life, study says

WEDNESDAY, May 20 (HealthDay News) -- A combination of aspirin and the anti-clotting drug dipyridamole reduces blockages and extends the useful life of new artery-vein access grafts used for kidney dialysis, new research has found.

When arteriovenous (AV) grafts fail, it is often due to stenosis -- a narrowing of blood vessels -- at the graft site, and subsequent clotting. If the AV graft is blocked, it can't be used for dialysis, and this is a major cause of declining health in dialysis patients, according to background information in a U.S. National Institute of Diabetes and Digestive and Kidney Diseases news release about the study.

In the study from the Dialysis Access Consortium, 649 patients with new AV grafts at 13 sites in the United States were randomly assigned to the combination treatment or placebo. The researchers found that the combination treatment decreased the rate of loss of primary unassisted graft patency (the useful life of a graft before it's blocked for the first time) by 18 percent and the rate of developing significant stenosis by 28 percent.

"Our trial results show that we now have a drug therapy that significantly prolongs the viability of AV grafts. This is an important step forward as we proceed to develop therapies to improve dialysis patients' quality of life," lead author Dr. Bradley S. Dixon, of the University of Iowa College of Medicine in Iowa City, said in the news release.

The study, which was supported by Boehringer Ingelheim Pharmaceuticals, Inc., appears in the May 21 issue of the New England Journal of Medicine.

"This drug combination provides a modest but important new therapy to keep AV grafts in good working order so patients can get the dialysis they need. But clearly, more research is needed to extend the useful life of AV grafts," Dr. Griffin P. Rodgers, director of the U.S. National Institute of Diabetes and Digestive and Kidney Diseases, said in the news release. The institute also supported the study.

Kidney failure affects more than half a million people in the United States, and 70 percent of them are on dialysis, according to background information in the news release.

More information

The NIDDK has more about vascular access for dialysis.



-- Robert Preidt



SOURCE: U.S. National Institute of Diabetes and Digestive and Kidney Diseases, news release, May 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Combo Keeps Kidney Artery-Vein Grafts Viable
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Steven Tonkinson, ... he has completed every year since it started in 2003. This year, he ran ... attention of fellow runners and NBA team the Miami Heat. , This Sunday, while ...
(Date:2/5/2016)... ... February 05, 2016 , ... Today, the Whole-Food Warrior TV show, ... much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, will stream on ... week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights Whole-Food Warriors - ...
(Date:2/5/2016)... ... 05, 2016 , ... The Muscular Dystrophy Association and Sailormen ... the 14th annual “Appetite for a Cure” campaign on Feb. 1 to raise ... related diseases that severely limit strength and mobility. , Now through March ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... George H. Van Allen have signed a joint enrollment and degree completion agreement. ... pathway toward associate and baccalaureate degrees at FHU|Dickson. , The agreement allows ...
(Date:2/5/2016)... ... 2016 , ... US Sports Camps , official operators of Nike Yoga ... kids yoga training. ChildLight Yoga Studio is centrally situated in the picturesque New England ... Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled to be partnering ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Wegener Polyangiitis - Pipeline Review, H2 ... Polyangiitis - Pipeline Review, H2 2015, provides an ... This report provides comprehensive information on the therapeutic ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ...
(Date:2/4/2016)... Frontier Pharma: Chronic Obstructive Pulmonary Disease ... Chronic Obstructive Pulmonary Disease (COPD) is ... the airways and lungs. Persistent breathing difficulties and ... one of the leading causes of morbidity and ... COPD is linked to cumulative exposure to risk ...
(Date:2/4/2016)... 2016 In response to the opioid abuse epidemic, ... for Medical Products and Tobacco, along with other FDA leaders, ... approach to opioid medications. The plan will focus on policies ... pain access to effective relief. --> ... Re-examine the risk-benefit paradigm for opioids and ensure that the ...
Breaking Medicine Technology: