Navigation Links
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
Date:3/25/2009

Adding third medicine to standard therapy made the difference, researchers say

WEDNESDAY, March 25 (HealthDay News) -- People with cancer of the larynx who received a three-drug chemotherapy combination were more likely to keep their larynx than those who received a two-drug treatment, French researchers report.

Their study compared treatment with a combination of three drugs -- docetaxel, cisplatin and 5-fluoruracil (TPF) -- during induction chemotherapy, against a combination of cisplatin and 5-fluoruracil (PF).

PF chemotherapy followed by radiation is commonly used as an alternative to surgery in the treatment of patients with locally advanced larynx (voice box) and hypopharynx cancer. Recent research has suggested that adding docetaxel to PF might further improve patient outcomes, according to background information in a news release about study.

The trial included 213 patients with advanced larynx and hypopharynx cancer. Those who responded to chemotherapy had follow-up radiation therapy and those who didn't respond to the chemotherapy had surgery.

After a median follow-up of three years, larynx preservation rates were just over 70 percent in the three-drug group and 57.5 percent for those on the two-drug regimen. Overall, 80 percent of patients in the TPF group responded to therapy, compared with a little more than 59 percent in the PF group. Patients in the TPF group experienced more severe infections than those in the PF group.

TPF was superior for patients with locally advanced cancers of the larynx and hypopharynx and this treatment can help more patients avoid total laryngectomy (removal of the voicebox), concluded the researchers at the Centre Hospitalier Regional et Universitaire de Tours.

However, they added that because the study was limited to patients with only larynx and hypopharynx cancer and was specially designed for organ preservation, "we cannot generalize the findings to all locally advanced head and neck cancers."

The study appears in the March 24 online issue of the Journal of the National Cancer Institute.

More information

The American Cancer Society has more about laryngeal and hypopharyngeal cancers.



-- Robert Preidt



SOURCE: Journal of the National Cancer Institute, news release, March 24, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Combo Screening Doesnt Spot Early Ovarian Cancer
2. Combo of Tests Might Spot Ovarian Cancer Early
3. Combo Treatment for Aggressive Brain Tumor May Lengthen Life
4. New Laser Combo Therapy Zaps Acne
5. Antibiotic Combo Fights Resistant TB
6. Two-Drug Combo May Lower Diabetics Kidney Risk
7. King Size Combo: New Report Reveals Broad Toll on Taxpayers by Bailed-Out Bank Goldman Sachs and Its Holdings in Burger King
8. Tobacco smoke and alcohol harm liver worse as combo
9. Cell Phones, Traffic a Deadly Combo for Kids
10. Combo Therapy Helps Multiple Myeloma Patients
11. Blood Pressure Pill Combo More Effective Than Diuretics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
Breaking Medicine Technology: