Navigation Links
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
Date:3/25/2009

Adding third medicine to standard therapy made the difference, researchers say

WEDNESDAY, March 25 (HealthDay News) -- People with cancer of the larynx who received a three-drug chemotherapy combination were more likely to keep their larynx than those who received a two-drug treatment, French researchers report.

Their study compared treatment with a combination of three drugs -- docetaxel, cisplatin and 5-fluoruracil (TPF) -- during induction chemotherapy, against a combination of cisplatin and 5-fluoruracil (PF).

PF chemotherapy followed by radiation is commonly used as an alternative to surgery in the treatment of patients with locally advanced larynx (voice box) and hypopharynx cancer. Recent research has suggested that adding docetaxel to PF might further improve patient outcomes, according to background information in a news release about study.

The trial included 213 patients with advanced larynx and hypopharynx cancer. Those who responded to chemotherapy had follow-up radiation therapy and those who didn't respond to the chemotherapy had surgery.

After a median follow-up of three years, larynx preservation rates were just over 70 percent in the three-drug group and 57.5 percent for those on the two-drug regimen. Overall, 80 percent of patients in the TPF group responded to therapy, compared with a little more than 59 percent in the PF group. Patients in the TPF group experienced more severe infections than those in the PF group.

TPF was superior for patients with locally advanced cancers of the larynx and hypopharynx and this treatment can help more patients avoid total laryngectomy (removal of the voicebox), concluded the researchers at the Centre Hospitalier Regional et Universitaire de Tours.

However, they added that because the study was limited to patients with only larynx and hypopharynx cancer and was specially designed for organ preservation, "we cannot generalize the findings to all locally advanced head and neck cancers."

The study appears in the March 24 online issue of the Journal of the National Cancer Institute.

More information

The American Cancer Society has more about laryngeal and hypopharyngeal cancers.



-- Robert Preidt



SOURCE: Journal of the National Cancer Institute, news release, March 24, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Combo Screening Doesnt Spot Early Ovarian Cancer
2. Combo of Tests Might Spot Ovarian Cancer Early
3. Combo Treatment for Aggressive Brain Tumor May Lengthen Life
4. New Laser Combo Therapy Zaps Acne
5. Antibiotic Combo Fights Resistant TB
6. Two-Drug Combo May Lower Diabetics Kidney Risk
7. King Size Combo: New Report Reveals Broad Toll on Taxpayers by Bailed-Out Bank Goldman Sachs and Its Holdings in Burger King
8. Tobacco smoke and alcohol harm liver worse as combo
9. Cell Phones, Traffic a Deadly Combo for Kids
10. Combo Therapy Helps Multiple Myeloma Patients
11. Blood Pressure Pill Combo More Effective Than Diuretics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
(Date:3/29/2017)... , ... March 29, 2017 , ... During the last ... provide free screening colonoscopies to eligible individuals in the local community. , Colon ... but regular screenings can detect colon cancer while it is small, confined and easier ...
(Date:3/29/2017)... FL (PRWEB) , ... March 30, 2017 , ... Grass pollen is the main cause ... allergic to the stuff. The season for grass pollen runs from May to July each ... a hay fever victim to do? HayMax™ allergen barrier balms ( http://www.haymax.us ) provide an ...
(Date:3/29/2017)... ... 2017 , ... Wells Pharmacy Network, a proud A4M Platinum ... World Congress, in Hollywood Florida April 6-8, 2017. , Ben David, CEO of ... in the training of physicians, scientists, and members of the public on anti-aging ...
(Date:3/29/2017)... Horeb, WI (PRWEB) , ... March 29, 2017 , ... ... patients on early orthodontic treatment and accepting new pediatric patients, with or without a ... help young patients have a better orthodontic outcome and experience. When patients receive early ...
(Date:3/29/2017)... ... March 29, 2017 , ... An inventor from Raynham, Mass., ... used in conjunction with my braces always rubbed against the inside of my ... prevent this problem." The O.B.S. was the result of his brainstorming. , This ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... N.Y. , March 29, 2017  BioSpecifics ... originated and continues to develop collagenase based-therapies with ... histolyticum (CCH) marketed as XIAFLEX ®  in the ... management will present a corporate overview at the ... on Wednesday, April 5, 2017 at 8:00 a.m. ...
(Date:3/29/2017)... Research and Markets has announced the addition of the "Italy ... report to their offering. ... Proton Therapy Market in Italy will double by ... currently three proton therapy centers in Italy that ... Italy , the first patients were treated with proton beams in ...
(Date:3/29/2017)... 29, 2017 Research and Markets has ... 2014 - 2025" report to their offering. ... The global ... million by 2025. Increasing geriatric population prone to orthopedic diseases ... navigation systems over the forecast period. Osteoarthritis and osteoporosis are ...
Breaking Medicine Technology: