Navigation Links
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
Date:3/25/2009

Adding third medicine to standard therapy made the difference, researchers say

WEDNESDAY, March 25 (HealthDay News) -- People with cancer of the larynx who received a three-drug chemotherapy combination were more likely to keep their larynx than those who received a two-drug treatment, French researchers report.

Their study compared treatment with a combination of three drugs -- docetaxel, cisplatin and 5-fluoruracil (TPF) -- during induction chemotherapy, against a combination of cisplatin and 5-fluoruracil (PF).

PF chemotherapy followed by radiation is commonly used as an alternative to surgery in the treatment of patients with locally advanced larynx (voice box) and hypopharynx cancer. Recent research has suggested that adding docetaxel to PF might further improve patient outcomes, according to background information in a news release about study.

The trial included 213 patients with advanced larynx and hypopharynx cancer. Those who responded to chemotherapy had follow-up radiation therapy and those who didn't respond to the chemotherapy had surgery.

After a median follow-up of three years, larynx preservation rates were just over 70 percent in the three-drug group and 57.5 percent for those on the two-drug regimen. Overall, 80 percent of patients in the TPF group responded to therapy, compared with a little more than 59 percent in the PF group. Patients in the TPF group experienced more severe infections than those in the PF group.

TPF was superior for patients with locally advanced cancers of the larynx and hypopharynx and this treatment can help more patients avoid total laryngectomy (removal of the voicebox), concluded the researchers at the Centre Hospitalier Regional et Universitaire de Tours.

However, they added that because the study was limited to patients with only larynx and hypopharynx cancer and was specially designed for organ preservation, "we cannot generalize the findings to all locally advanced head and neck cancers."

The study appears in the March 24 online issue of the Journal of the National Cancer Institute.

More information

The American Cancer Society has more about laryngeal and hypopharyngeal cancers.



-- Robert Preidt



SOURCE: Journal of the National Cancer Institute, news release, March 24, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Combo Screening Doesnt Spot Early Ovarian Cancer
2. Combo of Tests Might Spot Ovarian Cancer Early
3. Combo Treatment for Aggressive Brain Tumor May Lengthen Life
4. New Laser Combo Therapy Zaps Acne
5. Antibiotic Combo Fights Resistant TB
6. Two-Drug Combo May Lower Diabetics Kidney Risk
7. King Size Combo: New Report Reveals Broad Toll on Taxpayers by Bailed-Out Bank Goldman Sachs and Its Holdings in Burger King
8. Tobacco smoke and alcohol harm liver worse as combo
9. Cell Phones, Traffic a Deadly Combo for Kids
10. Combo Therapy Helps Multiple Myeloma Patients
11. Blood Pressure Pill Combo More Effective Than Diuretics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
(Date:1/14/2017)... ... 2017 , ... "TransFreeze Volume 3 is a self animating masking transition which allows users to ... X," said Christina Austin - CEO of Pixel Film Studios. , TransFreeze Volume 3 ... one clip to the next. , To use “Cut-Out First” presets, choose a ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... The 18th ... Avenida America hotel on March 3-4, 2017. This Congress is expertly designed to ... the management of patients with lung cancer. , Chaired by Dr. Giorgio V. Scagliotti, ...
(Date:1/13/2017)... ... 2017 , ... KOAMTAC ®, Inc., a leading manufacturer of Bluetooth barcode ... scanner and data collector at the National Retail Federation’s Big Show (NRF17) held January ... to the market’s need for more compact and rugged devices for collecting barcode data ...
(Date:1/13/2017)... PA (PRWEB) , ... January 13, 2017 , ... An inventor from Pahrump, Nev., used ... others. "My urologist had me wear a Foley catheter and urine bag for a half ... and uncomfortable, so I decided that there should be a better way to do this." ...
(Date:1/13/2017)... MN (PRWEB) , ... January 13, 2017 , ... People ... to endure jolts of pain whenever they brush their teeth. Sadly, most dental hygiene ... who have sensitive gums and teeth. For these people, continuing their daily oral care ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... LONDON , Jan. 16, 2017 ... delivering devices used for administering medications in a ... mainly used for therapeutic purposes in critical care, ... are required to make patient,s feel comfortable and ... medical errors which would lead to serious life ...
(Date:1/16/2017)...   The Harrington Discovery Institute at ... , has announced the 2017 recipients of Harrington ... physician-scientists whose research shows promise to advance the ... Institute – part of The Harrington Project for ... academic medicine: to advance early breakthroughs into the ...
(Date:1/16/2017)... According to the new market research report "Display Controller Market by ... LCD Controller), Application (Industrial Control, Medical Equipment, Automotive, Mobile Communication), and Geography ... to grow from USD 17.26 Billion in 2015 to reach USD 32.24 ... Continue Reading ... ...
Breaking Medicine Technology: