Navigation Links
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
Date:3/25/2009

Adding third medicine to standard therapy made the difference, researchers say

WEDNESDAY, March 25 (HealthDay News) -- People with cancer of the larynx who received a three-drug chemotherapy combination were more likely to keep their larynx than those who received a two-drug treatment, French researchers report.

Their study compared treatment with a combination of three drugs -- docetaxel, cisplatin and 5-fluoruracil (TPF) -- during induction chemotherapy, against a combination of cisplatin and 5-fluoruracil (PF).

PF chemotherapy followed by radiation is commonly used as an alternative to surgery in the treatment of patients with locally advanced larynx (voice box) and hypopharynx cancer. Recent research has suggested that adding docetaxel to PF might further improve patient outcomes, according to background information in a news release about study.

The trial included 213 patients with advanced larynx and hypopharynx cancer. Those who responded to chemotherapy had follow-up radiation therapy and those who didn't respond to the chemotherapy had surgery.

After a median follow-up of three years, larynx preservation rates were just over 70 percent in the three-drug group and 57.5 percent for those on the two-drug regimen. Overall, 80 percent of patients in the TPF group responded to therapy, compared with a little more than 59 percent in the PF group. Patients in the TPF group experienced more severe infections than those in the PF group.

TPF was superior for patients with locally advanced cancers of the larynx and hypopharynx and this treatment can help more patients avoid total laryngectomy (removal of the voicebox), concluded the researchers at the Centre Hospitalier Regional et Universitaire de Tours.

However, they added that because the study was limited to patients with only larynx and hypopharynx cancer and was specially designed for organ preservation, "we cannot generalize the findings to all locally advanced head and neck cancers."

The study appears in the March 24 online issue of the Journal of the National Cancer Institute.

More information

The American Cancer Society has more about laryngeal and hypopharyngeal cancers.



-- Robert Preidt



SOURCE: Journal of the National Cancer Institute, news release, March 24, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Combo Screening Doesnt Spot Early Ovarian Cancer
2. Combo of Tests Might Spot Ovarian Cancer Early
3. Combo Treatment for Aggressive Brain Tumor May Lengthen Life
4. New Laser Combo Therapy Zaps Acne
5. Antibiotic Combo Fights Resistant TB
6. Two-Drug Combo May Lower Diabetics Kidney Risk
7. King Size Combo: New Report Reveals Broad Toll on Taxpayers by Bailed-Out Bank Goldman Sachs and Its Holdings in Burger King
8. Tobacco smoke and alcohol harm liver worse as combo
9. Cell Phones, Traffic a Deadly Combo for Kids
10. Combo Therapy Helps Multiple Myeloma Patients
11. Blood Pressure Pill Combo More Effective Than Diuretics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
(Date:9/26/2017)... NJ (PRWEB) , ... September 26, 2017 , ... ... trained orthopedic surgeon and the Chair of the Leg, Ankle, and Foot Section ... is currently the only fellowship trained orthopedic surgeon at Hackensack UMC performing total ...
(Date:9/26/2017)... ... 2017 , ... The 2017 American Academy of Cosmetic Surgery World Congress on ... only the latest about cosmetic procedures to remove and replace fat, but also how ... “Fat really is magical, especially when it comes to the cosmetic patient,” says cosmetic ...
(Date:9/26/2017)... Pittsburgh, PA (PRWEB) , ... September 26, 2017 ... ... new chairmen who are collaborating on strategic and tactical plans for Pittcon 2018. ... Chemistry), took office as president along with his named vice president, Charles Gardner, ...
(Date:9/26/2017)... ... ... Morning Sunshine!: Finding Strength and Comfort in God”: a hopeful and compelling story ... God” is the creation of published author, Terri Braun, a mother of two with ... local mental health center for over twenty years, helping the severely and persistently mentally ...
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... “Sound of ... Song” is the creation of published author, Karmen Worden, a retired teacher with a ... Worden’s new book is an intriguing and inspiring story on loss, living with depression, ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
(Date:9/18/2017)... R.I. , Sept. 18, 2017 /PRNewswire/ ... the fields of bioinformatics and immune engineering, ... a protective avian influenza A (H7N9) vaccine. ... distantly related to seasonal influenza and presents ... rely on prior exposure to be effective. ...
Breaking Medicine Technology: