Navigation Links
Drug Combo Blocks Pain Without Impairing Movement

Chili pepper compound plus lidocaine derivative anesthetizes without numbness in rat study,,

WEDNESDAY, Oct. 3 (HealthDay News) -- A visit to the dentist could one day involve no pain and no numbness, Harvard researchers report.

In experiments with rats, the scientists combined capsaicin -- the ingredient that makes chili peppers hot -- and a drug called QX-314. This combination blocked pain-sensing neurons without the side effects of numbness or paralysis that accompany current pain relievers.

"We found a way to target local anesthetics to block only pain fibers," said lead researcher Dr. Clifford Woolf, the Richard Kitz Chair of Anesthesia Research at Harvard Medical School. "At present, any standard local anesthetic blocks pain fibers and fibers that produce numbness and paralysis. We have managed to block pain fibers without the numbness or paralysis."

QX-314 is a derivative of the lidocaine, a common local anesthetic. But QX-314 alone isn't able to get into cells to block electrical activity, and thus pain. When capsaicin is added, it opens the cell membranes of pain-sensing neurons and lets QX-314 into the cell.

In the study, Woolf's team found that the combination of capsaicin and QX-314 blocked pain-sensing neurons without affecting other nerve cells.

In additional experiments, the researchers injected the drugs into the paws of rats and found that the animals could tolerate more heat than usual. They also tried the drug combination on the nerve that runs down the rat's hind leg. These rats did not show any signs of pain, and five of the six moved and behaved normally. This showed that the drugs could block pain without affecting the nerves that control movement.

Woolf noted that this type of anesthetic could make dental visits easier. "Someone going to the dentist would be able to have a dental procedure without numbness," he said.

The anesthetic also could be used during childbirth. "The woman would feel something, but not pain," Woolf said. "More importantly, she would be able to walk instead of being paralyzed for some time, and there wouldn't be a reduction in blood pressure, which is a major reason why after an epidural people have to be monitored and kept flat.," he said.

A problem with the treatment is that the capsaicin can cause burning sensations until the QX-314 takes effect. But giving QX-314 about 10 minutes before the capsaicin minimizes this problem, Woolf noted.

The researchers are looking for ways to prevent the burning sensations. "We need to get a formulation that is as effective in humans as it was in the animals," Woolf said.

They are also looking for ways to prolong the pain relief and at the possibility of developing a pill instead of using injections, Woolf said.

More information

For more information on pain, visit the U.S. National Library of Medicine.

SOURCES: Clifford Woolf, M.D., Ph.D., Richard Kitz Chair of Anesthesia Research, Harvard Medical School, Boston; Oct. 4, 2007, Nature

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Drug Combo Works Better for children with ADHD, Tics
2. Scanning Combo Helps Detect Lung Cancer
3. Relief From Asthma With New Combo Therapy
4. Calcium-Vitamin D Combo For Reduced Fracture Risk
5. Drug Combo Improves Performance Of Multiple Sclerosis Drug
6. Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety?
7. HER-2 Positive Breast Cancer Patients May Benefit With a Combo Drug Strategy
8. The Combo Treatment Is Effective to Treat Type 1 Diabetes in Mice
9. Doomed Duo: Obesity and Type 2 Diabetes Combo, Can Nip Life in the Bud
10. Arimidex-Herceptin Combo Therapy For Breast Cancer-Clinical Trial Findings
11. Fuzeon and MK-0518 Combo Holds Promise For HIV
Post Your Comments:
(Date:11/26/2015)... ... 2015 , ... Somu Sivaramakrishnan announced today that he joined ... offers travelers, value and care based Travel Services, including exclusive pricing on a ... cabin upgrades and special amenities such as, shore excursions, discounted fares, travel gifts ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... Jobs in ... by healthcare professionals and offered by healthcare staffing agency Aureus Medical Group . ... the month of October 2015 among those searching for healthcare jobs through the company’s ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... process, participated in the 61st annual Employee Benefits Conference. The Employee Benefits Conference ... Sunday, November 8th through Wednesday, November 11th, 2015. The conference was held at ...
(Date:11/26/2015)... Karnataka (PRWEB) , ... November ... ... innovative online platform for mental health and wellness consultation, has collaborated with ... to holistically address their reader’s queries on topics on mental and emotional ...
(Date:11/25/2015)... ... November 25, 2015 , ... Additional ... those found on mammography, according to a study published online in the journal ... seen on mammography may necessitate a change in treatment. , Breast MRI is ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Carolina , 26 november 2015 /PRNewswire/ ... (AAIPharma/CML) kondigt de geplande investering aan van ... van de laboratoria en het mondiale hoofdkantoor ... De uitbreiding zal resulteren in extra kantoorruimte ... voldaan aan de groeiende behoeften van de ...
(Date:11/26/2015)... SAN FRANCISCO , November 26, 2015 ... 1.82 billion by 2022, according to a new report by ... as Chronic Kidney Disease (CKD) which demands kidney transplantation is ... convenient and cost effective substitute for organ transplantation. --> ... 1.82 billion by 2022, according to a new report by ...
(Date:11/26/2015)... , November 26, 2015 ... Juntendo universitetssjukhus ser potential att använda ... magnetresonansbilder (MR-bilder) för patienter med multipel ... ett forskningsavtal med SyntheticMR AB för att ... forskningsprojekt på sjukhuset. Med SyMRI kan man ...
Breaking Medicine Technology: