Navigation Links
Drug Combo Blocks Pain Without Impairing Movement
Date:10/3/2007

Chili pepper compound plus lidocaine derivative anesthetizes without numbness in rat study,,

WEDNESDAY, Oct. 3 (HealthDay News) -- A visit to the dentist could one day involve no pain and no numbness, Harvard researchers report.

In experiments with rats, the scientists combined capsaicin -- the ingredient that makes chili peppers hot -- and a drug called QX-314. This combination blocked pain-sensing neurons without the side effects of numbness or paralysis that accompany current pain relievers.

"We found a way to target local anesthetics to block only pain fibers," said lead researcher Dr. Clifford Woolf, the Richard Kitz Chair of Anesthesia Research at Harvard Medical School. "At present, any standard local anesthetic blocks pain fibers and fibers that produce numbness and paralysis. We have managed to block pain fibers without the numbness or paralysis."

QX-314 is a derivative of the lidocaine, a common local anesthetic. But QX-314 alone isn't able to get into cells to block electrical activity, and thus pain. When capsaicin is added, it opens the cell membranes of pain-sensing neurons and lets QX-314 into the cell.

In the study, Woolf's team found that the combination of capsaicin and QX-314 blocked pain-sensing neurons without affecting other nerve cells.

In additional experiments, the researchers injected the drugs into the paws of rats and found that the animals could tolerate more heat than usual. They also tried the drug combination on the nerve that runs down the rat's hind leg. These rats did not show any signs of pain, and five of the six moved and behaved normally. This showed that the drugs could block pain without affecting the nerves that control movement.

Woolf noted that this type of anesthetic could make dental visits easier. "Someone going to the dentist would be able to have a dental procedure without numbness," he said.

The anesthetic also could be used during childbirth. "The woman would feel something, but not pain," Woolf said. "More importantly, she would be able to walk instead of being paralyzed for some time, and there wouldn't be a reduction in blood pressure, which is a major reason why after an epidural people have to be monitored and kept flat.," he said.

A problem with the treatment is that the capsaicin can cause burning sensations until the QX-314 takes effect. But giving QX-314 about 10 minutes before the capsaicin minimizes this problem, Woolf noted.

The researchers are looking for ways to prevent the burning sensations. "We need to get a formulation that is as effective in humans as it was in the animals," Woolf said.

They are also looking for ways to prolong the pain relief and at the possibility of developing a pill instead of using injections, Woolf said.

More information

For more information on pain, visit the U.S. National Library of Medicine.



SOURCES: Clifford Woolf, M.D., Ph.D., Richard Kitz Chair of Anesthesia Research, Harvard Medical School, Boston; Oct. 4, 2007, Nature


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Drug Combo Works Better for children with ADHD, Tics
2. Scanning Combo Helps Detect Lung Cancer
3. Relief From Asthma With New Combo Therapy
4. Calcium-Vitamin D Combo For Reduced Fracture Risk
5. Drug Combo Improves Performance Of Multiple Sclerosis Drug
6. Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety?
7. HER-2 Positive Breast Cancer Patients May Benefit With a Combo Drug Strategy
8. The Combo Treatment Is Effective to Treat Type 1 Diabetes in Mice
9. Doomed Duo: Obesity and Type 2 Diabetes Combo, Can Nip Life in the Bud
10. Arimidex-Herceptin Combo Therapy For Breast Cancer-Clinical Trial Findings
11. Fuzeon and MK-0518 Combo Holds Promise For HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading ... Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly ... CBD form that can be easily incorporated into liquid products, while reducing costs to ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... Maryland (PRWEB) , ... October 12, 2017 , ... ... magnetic drug delivery system that we intend to develop to enable prevention of ... can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: