Navigation Links
Drug-Coated Stents Better at Keeping Arteries Open

But they show no lifesaving benefit over bare-metal version, studies show

WEDNESDAY, May 6 (HealthDay News) -- Although arteries propped open by drug-coated stents are less likely to become blocked again than those treated with bare-metal stents, the risk of death and heart attacks is virtually identical between the two devices, major studies in Sweden and the United States show.

The Swedish results eliminate concerns raised by an earlier study that the drug-coated stents might actually be more dangerous, said Dr. Stefan K. James, an associate professor of cardiology at Uppsala University and lead author of the Swedish study appearing in the May 7 issue of the New England Journal of Medicine.

The earlier study, of Swedes given stents in 2003 and 2004, found a higher death rate among those who got the drug-coated kind. The follow-up study of 47,967 Swedes who had stents implanted between 2003 and 2006 found "no overall difference between the group that received drug-eluting stents and the group that received bare-metal stents in the combined endpoint of death or myocardial infarction [heart attack]," the report said.

But the rate of re-stenosis -- new blockage of the treated artery -- was three per 100 patient years versus 4.7 for the bare-metal recipients.

So the earlier result was "just a scary signal" that proved to be false, James said.

"For me, this paper shows that there should now be no real concerns about the safety of drug-eluting stents and that the emphasis should shift back to considering the relative efficacy of drug-eluting stents and bare-metal stents," Dr. Eric Eeckhout, a spokesman for the European College of Cardiology, said in a statement.

James's interpretation of the study is that use of drug-coated stents should be limited to cases where the risk of re-stenosis is high -- when the blockages are in smaller blood vessels and are long in length and when the person has diabetes, for example.

Cost plays a role in his judgment, James said. "The prices of drug-coated stents have gone down in Europe, but they cost twice as much here [in Europe] as the bare-metal stents," he said.

And the study results are not definitive because they did not come from a randomized, controlled trial, the gold standard of medical research, James said.

The American study, reported in the same journal, was such a controlled trial. It included 3,006 people given stents after heart attacks, comparing outcomes for the 2,257 who got Taxus stents, coated with the drug paclitaxel, with the 749 who received bare-metal stents.

Unlike the Swedish trial, which was funded by governmental and noncommercial organizations, the American trial was supported by Boston Scientific, which markets the Taxus stent.

Again, the rate of re-stenosis was significantly lower in the group given a coated stent: 10 percent versus 22.9 percent in the first 13 months. There was an identical 12-month death rate, 3.5 percent, in both groups, and no difference in the incidence of serious cardiac problems, such as second heart attacks.

It's not surprising that there was no lifesaving benefit to the drug-eluting stent, said study author Dr. Gregg W. Stone, a professor of medicine at Columbia University Medical Center.

The procedure done in the study was the reopening of the blocked artery that caused the heart attack, Stone said. "What keeps them alive is whether or not they have another heart attack," he said. "We don't expect them [the stents] to save lives."

He was strict in drawing a conclusion from the trial: "What this study shows is that this paclitaxel-eluting stent is safe to use in patients with an evolving heart attack, and that it reduced the incidence of re-stenosis by about 40 percent."

That conclusion cannot be extended to other drug-coated stents because "drug-eluting stents are different from each other," Stone said. Another controlled trial would be needed to determine whether the differences are significant in ultimate results, he noted.

More information

The U.S. Food and Drug Administration has more on stents.

SOURCES: Stefan K. James, M.D., Ph.D., professor, cardiology, Uppsala University, Sweden; Gregg W. Stone, M.D., professor, medicine, Columbia University Medical Center, New York City; May 7, 2009, New England Journal of Medicine

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug-Coated Sponges May Limit Catheter Infections
2. UT Southwestern researchers find drug-coated stents less risky for heart bypass patients
3. Drug-Coated Stents Reduce Repeat Artery Procedures
4. More patients with drug-coated cardiac stents survive, avoid costly follow-up procedures
5. Drug-Coated Stents Still Spark Debate
6. New Drug-Coated Stent Does Well in Early Trial
7. Drug-coated balloon overcomes in-stent restenosis
8. Drug-Coated Balloons Keep Leg Arteries Open: Study
9. Drug-Coated Stents Better Than Bare-Metal Ones in Complex Cases
10. Drug-Coated Stents No Riskier in Long Run Than Bare Metal Ones
11. Study Finds Benefits With Drug-Coated Stents
Post Your Comments:
Related Image:
Drug-Coated Stents Better at Keeping Arteries Open
(Date:10/10/2015)... (PRWEB) , ... October 10, 2015 , ... ... Brecher & Miller is pleased to be recognized by The National Law Journal ... list acknowledges the 50 law firms across the United States who obtained the ...
(Date:10/9/2015)... ... October 09, 2015 , ... For many, October is a month whose focus ... effort to find a cure. At Beverly Hills Physicians in Southern California, it is ... their Bra Collection Campaign, Beverly Hills Physicians is encouraging patients and non-patients alike to ...
(Date:10/9/2015)... , ... October 09, 2015 , ... ... best audiologists in The Tennessean's eighth annual Toast of Music City, a reader’s ... Local Nashville residents nominated and cast votes for their favorite businesses in over ...
(Date:10/9/2015)... ... October 09, 2015 , ... The Asthma and Allergy Foundation of America (AAFA) ... and Prevention (CDC) to improve the knowledge and skills of underserved adults with asthma. ... project by the CDC and allows AAFA to continue vital efforts to educate people ...
(Date:10/9/2015)... ... October 09, 2015 , ... MMJ PhytoTech ... with Ed Begley Jr., airing 1st QT 2016 via the Discovery Channel. Dates ... MMJ Phytotech Limited (MMJ) – a global leader in the field of commercializing ...
Breaking Medicine News(10 mins):
... a health ratings company, the top 5 % of U.S ... lower the risk of death to patients by almost 27%, ... of complications. //,Health Grades, as part of their checks for ... United States. ,Death and complication rates for major surgeries ...
... is spending large amount of money on the Medicare sector ... act quickly otherwise the // problem will be blown out ... as high as 16% of gross domestic product and growing ... costs are to be borne by the individuals, businesses, the ...
... have advised expectant mothers to reduce the intake of anti-depressant ... with withdrawal symptoms. // The newborn babies of such ... and tremors within 48 hours after birth. ... women who had taken higher doses of the medicines. The ...
... approved the drug TEMODAL in combination with Radiotherapy ... // The drug TEMODAL that contains Temozolomide is ... treating two forms of brain cancer Glioblastoma multiforme ... the drug TEMODAL was tested on newly diagnosed ...
... for the worst possible results does not serve any ... in the end is the same for both categories ... University and Jonathon Brown of the University of Washington, ... their findings in the latest issue of the journal ...
... UK based doctors have called upon Muslim leaders, particularly in ... community. // This has been reported by the British Medical ... called for in anti-tobacco campaigns. ,The researchers ... countries with the highest proportion of Muslims. Smoking rates in ...
Cached Medicine News:
(Date:10/9/2015)... 2015  Insulet Corporation (NASDAQ: PODD ), the ... its OmniPod ® Insulin Management System, today announced ... quarter of 2015 on November 5, 2015 after the ... release, management will host a conference call that day ... . A replay will be available two hours after ...
(Date:10/9/2015)... MOUNT BRYDGES, Ontario , Oct. 9, ... of ergonomic radiology furniture, monitor mounting solutions ... Texas Children,s Hospital,s Department of Pediatric Radiology ... "ballroom concept."  RedRick Technologies provided ergonomic design ... facilitating productivity, clinical collaboration and teaching. ...
(Date:10/9/2015)... PUNE, India , October 9, 2015 /PRNewswire/ ... with analysis of major players. --> ... major players. --> announces addition ... current status and 2020 forecasts for global markets ... India along with analysis of ...
Breaking Medicine Technology:
... Claret Medical, Inc. announced today that its Montage ... first complete system of filtration to protect both carotid ... or brachial access, providing complete neuro protection during intravascular ... unique design of the Montage System provides for not ...
... 2011 Althera Medical Ltd. announced today that it ... treatment of cancer tumors with alpha radiation at Israel,s ... of Radiation Oncology at the Sourasky Medical Center and ... of the Head and Neck Tumor Service at Rabin,s ...
Cached Medicine Technology:
... ideal where space is restricted. Due to ... and flexible in every situation. For many ... be positioned optimally on the JUPITER during ... the operating theatre, the high level of ...
... schaerer axis 800 operating ... designed for those disciplines ... access. The stability, the ... the offset positioned telescoping ...
... words "mobile operating table" literally! The Alphastar 1132 ... of a general purpose operating table - is ... operations, a cable connected hand control, an IR-hand ... there is a control panel at the top ...
... introduce the Cmax operating table that combines ... surgical table with the radiolucence and precise ... the most advanced, versatile surgical table on ... to support advancements in surgical procedures and ...
Medicine Products: